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... Common food items that cause food allergy are milk, peanuts, eggs, shellfish, tree-nuts, wheat, rice and fruit (Kotra, Chaudhary, and Neetu 2015). Food allergy happens as an adverse reaction resulting from an immunological response from a food antigen. ...
... Bioinformatics is the science that deals with biology and computer science, and for the analysis part statistical analytical tools are employed. The information gathered is then represented in a statistical format (Kotra, Chaudhary, and Neetu 2015). Some conducted studies show that common molecular features of protein with same homology or in the same or different protein family account for clinically significant cross-reactivity and sensitivity. ...
... BLAST and FASTA databases are used to determine the amino acid sequences more promptly, likewise SDAP provides the protein family grouping for most of the proteinaceous allergens (Kotra, Chaudhary, and Neetu 2015 FASTA and BLASTp can be used to for the following purposes manly: comparison of sequence of allergenic proteins, prediction of the food allergenicity and sequence combination and structural information(Kotra, Chaudhary, and Neetu 2015). Another power bioinformatics tool is molecular dynamics simulation tool(Zhou et al. 2021). ...
This literature review mainly deals with the concepts of food science,food allergy,allergenomics,bioinformatics and its application in solving challenges pertaining to food allergy.When an after eating a certain food, the immune system gives out a reaction,it is defined as Food Allergy.It is a complex disease that has many challenging area related to its cure and is a worldwide problem. Bioinformatics help in providing solutions to these challenges. As allergens are mainly proteins.There are many allergy databases and tools available in the market that can be used to identify the differences between novel proteins and food allergens that could be the epicentre of multiple allergy syndromes.This review article talks about food allergenicity,allergy and computational approaches employed to solves issues related to it.
