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Mechanism of action of proton pump inhibitors in a parietal cell. As hydrogen secretion is inhibited by PPIs, the subsequent formation of hydrochloric acid is thus inhibited as well resulting in an alkalization of the stomach contents
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Background
Proton pump inhibitors (PPIs) are the most efficacious and common medications for gastric acid suppression. However, PPIs continue to perpetuate safety concerns due to the availability as an over-the-counter medication. This uncontrolled use of PPIs has recently been shown to be associated with the increased health risks.
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Context in source publication
Context 1
... ions are then transported into the lumen of the stomach by the H + /K + ATPase pump in exchange for potassium. Bicarbonate is exchanged for chloride from the blood on the basolateral side of the parietal cell and the Cl-ions are transported to the lumen of the stomach to form HCl. Figure 2 depicts an overview of the mechanism of action of proton pump inhibitors described here. ...
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Proton pump inhibitor (PPI) works by blocking the hydrogen-potassium ATPase inhibitor H/K ATPase inhibitor located on gastric parietal cells. It blocks the last step of acid production that is why it is more potent and effective than other acid suppressants like H2 blockers, 99% of gastric acid secretion is reduced by using it. Objective: To evalua...
