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Mean values of emotional functioning, fatigue, and constipation for the Japanese and Dutch patients combined, on three measurement occasions.
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This study examined quality of life (QOL) and illness perceptions in Dutch and Japanese patients with non-small-cell lung cancer, thereby extending the body of knowledge on cultural differences and psychosocial aspects of this illness. 24 Dutch and 22 Japanese patients with non-small-cell lung cancer filled out questionnaires on three occasions: im...
Context in source publication
Context 1
... Significant differences between the Japanese and the Dutch patients were found on global health status (p = 0.008), emotional functioning (p = 0.005), social functioning (p = 0.001), constipation (p = 0.012), and financial difficulties (p < 0.001), with the Dutch patients having significantly more favorable average scores on all five variables (Fig. ...
Citations
... In this case, a negative illness perception (higher scores on the B-IPQ) would be associated with lower scores on QOL. The relationship between illness perception and QOL has been studied in different pathologies, such as cancer [43,44], kidney disease [45][46][47], and heart disease [48]. In the specific case of epilepsy, Shallcross et al. [49] found that illness perceptions act as mediators between depression and QOL, supporting the idea that psychological/social factors have a significant and even more important impact on QOL than some clinical variables of epilepsy. ...
This study presents the cultural and linguistic adaptation and psychometric properties of the Argentine version of the Quality of Life in Epilepsy Inventory (QOLIE-31P) scale.
An instrumental study was carried out. A version of QOLIE-31P translated into Spanish was provided by the original authors. To assess the content validity, evaluation of expert judges was requested, and the degree of agreement was determined. The instrument was administered to 212 people with epilepsy (PWE) of Argentina, together with the BDI-II, B-IPQ and a sociodemographic questionnaire. A descriptive analysis of the sample was carried out. Discriminative capacity of the items was performed. Cronbach's alpha was calculated to assess reliability. To study the dimensional structure of the instrument, a confirmatory factorial analysis (CFA) was performed. Convergent and discriminant validity was tested through mean difference tests, linear correlation, and regression analysis.
Aiken's V coefficients ranged between .90 and 1 (acceptable), which allows to state that a conceptually and linguistically equivalent version of the QOLIE-31P was reached. Cronbach's Alpha of 0.94 was obtained for the Total Scale (optimal). As a result of CFA, 7 factors were obtained, being the dimensional structure similar to the original version. Also, unemployed PWE reported significant lower scores than employed PWE. Finally, QOLIE-31P scores negatively correlated with depression symptom severity and negative illness perception.
The Argentine version of the QOLIE-31P is a valid and reliable instrument, presenting good psychometric properties, such as high internal consistency and a dimensional structure similar to that of the original version.
... To date, most studies assessing QoL in LC care focus on the impact of novel treatments, such as those in clinical trials [6,7,17,[21][22][23]31,32,46]. Therefore, this study adds important insights to the scarce information on QoL priorities of patients with LC in a wider context of care as well as daily life [18,36,47]. ...
Background:
While the LC treatment landscape has rapidly evolved in recent years, easing symptom burden and treatment side effects remains a central consideration in disease control.
Objective:
The aim of this study was to assess the relative importance of dimensions of lung cancer (LC) care to patients, and to explore the disease burden including socio-economic aspects not commonly covered in patient reported outcomes instruments.
Methods:
A questionnaire was sent to LC patients and their caregivers to rate the value of a diverse set of quality of life dimensions in care, to evaluate communication between health care professionals (HCPs) and patients, and to explore the economic impact on respondents. The survey included questions on dimensions of care covered by patient -reported outcomes instruments for Quality-of-life evaluation (FACT-L, EQ5D, QLQ-C30 and QLQ-LC13), as well as the ICHOM standard set of patient-centred outcomes for lung cancer. The survey respondents were participants on Carenity's patient community platform living in either France, UK, Germany, Italy, or Spain.
Results:
The survey included 150 respondents (77% patients, 33% caregivers). "Physical well-being" and "End-of-life care" (median scores of 9.6 [7.7-10] and 9.7 [8.0-10] on a 10-point scale) were rated highest among the different value dimensions assessed. "Physical well-being and functioning" was the dimension most frequently discussed with health care professionals (55%), while only 17% reported discussing "End-of-life care." Among patients younger than 65 years, 43% stopped working after diagnosis. Among respondents that indicated their monthly household income before and after diagnosis, 55% reported a loss of income.
Conclusions:
Our results showed the relevance of a broad range of aspects of care for the Quality-of-life of LC patients. End-of-life care was the dimension of care rated highest by LC patients irrespective of stage at diagnosis; however, this aspect is least frequently discussed with HCPs. The results also highlight the considerable socio-economic impact of the disease, despite insurance coverage of direct costs.
... Our study highlights the specific contributions of illness perceptions to glaucoma patients' VRQoL after controlling for demographic and clinical variables. Illness perception has been considered an important psychological factor affecting adherence and QoL in patients with some chronic diseases, such as cancer [28], chronic kidney disease [29], diabetes [30], cardiovascular disease [31] and chronic obstructive pulmonary disease (COPD) [32]. Specifically, previous studies have reported that higher identity was a strong predictor of outcomes, predicting lower QoL in coronary heart disease (CHD) patients [15], which is consistent with our findings. ...
Purpose
To explore the predictive effects of illness perceptions on vision-related quality of life (VRQoL) in Chinese glaucoma patients.
Methods
In this cross-sectional study, 97 patients with glaucoma completed the brief illness perception questionnaire (BIPQ), the glaucoma quality of life-15 (GQL-15) questionnaire, and a questionnaire regarding sociodemographic and clinical information. A correlation analysis and hierarchical linear regression analysis were performed.
Results
The BIPQ total score was positively correlated with the total score of the GQL-15 questionnaire and the scores of its four dimensions. Chronic comorbidities, the type of glaucoma, the best-corrected visual acuity (BCVA), the mean defect (MD) of visual field in the better eye, and identity in the BIPQ were critical predictors of VRQoL. Illness perceptions independently accounted for 7.8% of the variance in the VRQoL of glaucoma patients.
Conclusions
Patients with stronger illness perceptions and those who perceive themselves as having more glaucoma symptoms are likely to experience worse VRQoL. Illness perceptions in glaucoma patients deserve clinical attention, and further studies are needed to examine whether cognitive interventions targeting illness perceptions can improve VRQoL.
... 11,12 According to extant literature, the health-related QOL (HRQOL) of cancer survivors is positively affected by social support (including that from their family, peers, and healthcare providers) 13,14 and knowledge about their treatment options. 15 Additionally, psychosocial problems, like those arising from the awareness concerning the severity of the disease, 16,17 depression, 18,19 and a fear of recurrence and death, 14,20 also negatively impact cancer patients' HRQOL. In Korea, the HRQOL of adult cancer survivors was found to be significantly associated with being of a younger age, being male, having a higher income, experiencing fewer depressive symptoms, and possessing a subjectively positive perceived health status. ...
Objective
This study identified group patterns in the quality of life (QOL), as well as examining factors associated with group membership, among non-muscle invasive bladder cancer (NMIBC) survivors.
Methods
This was a cross-sectional study involving 278 participating NMIBC survivors. Mplus version 7.2 was used to perform the latent profile analysis of QOL using the EORTC QLQ-NMIBC-24. The participants’ social support, self-efficacy, knowledge level, depression, perceived severity of and susceptibility of cancer recurrence, and their demographic and clinical characteristics were compared between the subgroups, with a logistic regression analysis being adopted to examine the factors associated with the QOL subgroups.
Results
The NMIBC survivors based on the QOL were classified into two subgroups: “QOL – high” (81.3%) and “QOL – low” (18.7%). Having ≥3 disease recurrences, perceived susceptibility toward and severity of cancer recurrence, and having depressive symptoms were significantly associated with the “QOL-low” group.
Conclusions
Participants with frequent recurrences of NMIBC, higher perceived susceptibility and severity levels, and depressive symptoms had lower QOL. Therefore, it is necessary to develop intervention programs targeting participants with these characteristics to improve their QOL.
... The effect of illness perceptions on both behavioural and medical outcomes has been shown in various conditions [11][12][13]. Studies have shown that stronger negative illness perceptions are associated with worse outcomes, whereas positive perceptions with better outcomes [14]. For example, in post-myocardial infarction patients who underwent cardiac rehabilitation, stronger positive perceptions were associated with better physical therapy/ rehabilitation attendance and faster resumption to work (behavioural outcomes) [14,15]. ...
To understand how individuals (self-)manage obesity, insight is needed into how patients perceive their condition and how this perception translates into health outcomes (e.g., health-related quality of life, HRQOL). Our objectives were (1) to examine illness perceptions in individuals with overweight and obesity, and (2) to investigate associations of these perceptions with physical and mental HRQOL.
In a cross-sectional analysis of the Netherlands Epidemiology of Obesity Study (n = 6432; 52% women), illness perceptions were assessed using the Brief Illness Perception Questionnaire, and HRQOL was assessed using the 36-Item Short-Form Health Survey. Illness perceptions were calculated for different categories of overall, abdominal, and metabolically unhealthy obesity. We investigated associations of illness perceptions with HRQOL using BMI-stratified multivariable linear regression analyses.
Compared to individuals with normal weight, individuals with obesity believed to a higher extent that their condition had more serious consequences [Mean Difference (95%CI): 1.8 (1.6–2.0)], persisted for a longer time [3.4 (3.2–3.6)], manifested in more symptoms [3.8 (3.6–4.0)], caused more worry [4.2 (3.9–4.4)] and emotional distress [2.0 (1.8–2.2)], but was more manageable with medical treatment [3.1 (2.9–3.4)]. They perceived to a lesser extent that they had personal control [−2.2 (−2.4, −2.0)] and understanding [−0.3 (−0.5, −0.1)] regarding their condition. These negative perceptions were less pronounced in individuals with abdominal obesity. Behaviour/Lifestyle was attributed by 73% of participants to be the cause of their obesity. Stronger negative illness perceptions were associated with impaired HRQOL, particularly the physical component.
Individuals with obesity perceived their conditions as threatening, and this seemed somewhat stronger in individuals with overall obesity than those with abdominal obesity. Behaviour/Lifestyle is a crucial target intervention and empowering self-management behaviour to achieve a healthy body weight may deliver promising results. In addition, strategies that aim to change negative perceptions of obesity into more adaptive ones may improve HRQOL.
... Our study highlights the speci c contributions of illness perceptions to glaucoma patients' VRQoL after controlling for demographic and clinical variables. Illness perception has been considered an important psychological factor affecting adherence and QoL in patients with some chronic diseases, such as cancer [27], chronic kidney disease[28], diabetes [29], cardiovascular disease [30] and chronic obstructive pulmonary disease (COPD) [31]. Speci cally, previous studies have reported that higher identity was a strong predictor of outcomes, predicting lower QoL in coronary heart disease (CHD) patients [15], which is consistent with our ndings. ...
Purpose: To explore the predictive effect of illness perceptions on vision-related quality of life (VRQoL) in Chinese glaucoma patients.
Methods: In this cross-sectional study, 97 patients with glaucoma completed the Brief Illness Perception Questionnaire (BIPQ), the Glaucoma Quality of Life-15 (GQL-15), and a questionnaire with sociodemographic and clinical information. Correlation analysis and hierarchical linear regression analysis were performed.
Results: The BIPQ total score was positively correlated with the scores of the total GQL-15 and its four dimensions. Chronic comorbidities, type of glaucoma, best-corrected visual acuity (BCVA), mean defect (MD) of visual field in the better eye, and identity in the BIPQ were the critical predictors of VRQoL. Illness perceptions independently accounted for 7.8% of the variance in the VRQoL of glaucoma patients.
Conclusions: Patients with stronger illness perceptions who perceive themselves as having more glaucoma symptoms are likely to experience worse VRQoL. Illness perceptions in glaucoma patients deserve clinical attention, and further studies are needed to examine whether cognitive interventions targeting illness perceptions can improve VRQoL.
... In addition, a previous study by the authors on patients with NSCLC in Japan and The Netherlands concluded that illness beliefs affected health-related changes in QOL in individual patients (17). Furthermore, another study detected differences in illness perceptions and QOL between Japanese and Dutch patients with NSCLC (18). What remains unclear in the literature, however, is the association between QOL and illness perceptions and changes in QOL over time. ...
... Kaptein et al (18) reported that accounting for symptoms, illness perceptions and QOL may enhance treatment protocols and outcomes for patients with NSCLC. According to Lehto (28), there is also an urgent need for further research on lung cancer populations that uses baseline psychological distress as an eligibility criterion, given emerging evidence that it may improve the evaluation of intervention benefits over time. ...
... 22 Despite cultural differences, a considerable degree of conceptual equivalence of QoL in Japanese and Dutch patients with cancer was observed. [23][24][25][26] This indicated a satisfactory structural and cross-cultural equivalence for the use of EORTC-QLQ-C30 with regard to items measuring QoL. 21 Subsequently, Japanese cancer researchers developed a methodology to assess QoL in a clinical setting. ...
Objective
Monitoring quality of life (QoL) in patients with cancer can provide insight into functional, psychological and social consequences associated with illness and its treatment. The primary objective of this study is to examine the influence of cultural factors on the communication between the patient and the health care provider and the perceived QoL in women with breast cancer in Japan and the Netherlands.
Methods
In Japanese and Dutch women with early breast cancer, the number, content and frequency of QoL-related issues discussed at the medical encounter were studied. Patients completed questionnaires regarding QoL and evaluation of communication with the CareNoteBook.
Results
The total number, frequency and content of QoL-related issues discussed differed between the two countries. Japanese women (n = 134) were significantly more reticent in discussing QoL-issues than the Dutch women (n = 70) (p < .001). Furthermore, Dutch patients perceived the CareNoteBook methodology significantly more positively than the Japanese patients (p < .001). Both groups supported the regular assessment via a CareNoteBook methodology.
Conclusions
Japanese women are more reluctant in expressing their problems with the illness, its treatment and patient-physician communication than Dutch women.
... Health-related quality of life (HRQoL) may be measured to reveal the physiological, psychological, and social functions of patients with RA [3,11,12]. Illness perception is associated with quality of life, social function, and disease prognosis [13][14][15][16][17][18]. Such knowledge is applied to guide clinicians in the management of RA, to improve the HRQoL and the prognosis of their patients. ...
Objectives
For patients with rheumatoid arthritis (RA) in China, little is known of how their illness perceptions affect their health-related quality of life (HRQoL). The present study investigated associations between specific illness perceptions due to RA and HRQoL features.
Methods
For 191 patients with RA, illness perceptions were measured using the Brief Illness Perceptions Questionnaire (BIPQ) comprising 8 domains. HRQoL was determined with the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36). Multivariate linear regression analyses were performed.
Results
The overall BIPQ of patients with RA was 49.09 ± 11.06. The highest and lowest scores were for concern (9.15 ± 1.81) and personal control (4.30 ± 2.52), respectively. Multivariate stepwise regression analyses showed that the overall BIPQ was significantly negatively associated with each HRQoL feature, and HRQoL total score (β = − 0.343, P < 0.001, 95% CI − 7.080 to − 4.077). Positive associations between BIPQ features and HRQoL included personal control (β = 0.119, P = 0.004, 95% CI 2.857–14.194) and treatment control (β = 0.084, P = 0.029, 95% CI 0.640–12.391). Negative associations with HRQoL were identity (β = − 0.105, P = 0.034, 95% CI − 13.159 to − 0.430) and emotional response (β = − 0.207, P < 0.001, 95% CI − 18.334 to − 6.811).
Conclusions
Patients with RA in China perceive their illness in ways that affect their HRQoL. These results suggest that strategies that target these perceptions may improve the quality of life of these patients.
... 17 Additionally, various dimensions of disease or illness perception have been associated with different aspects of the outcome. 18 Secondly, the discrepancy might also be the result of the difference in AD healthcare organization. In Japan, focus on concomitant TCS use is expected to be higher compared with NL, possibly resulting in improvement of their disease. ...
Background:
Dupilumab was equally effective among all racial subgroups in clinical trials, but a direct comparison in daily practice is lacking.
Objective:
To investigate effectiveness of dupilumab in atopic dermatitis (AD) patients in the Netherlands versus Japan up to 80 weeks of treatment.
Methods:
A longitudinal comparative cohort study was conducted in AD patients who were treated with dupilumab in daily practice. We used linear mixed-effects models to determine changes in time.
Results:
We found statistically significant differences in sex, disease onset, BMI and therapeutic history between Dutch (n=208) and Japanese (n=153) patients. The baseline Eczema Area and Severity Index (EASI) score was higher in Japanese patients (23.8 v.s. 14.8), while baseline Patient-Reported Outcome Measures (PROMs) were higher in Dutch patients. EASI scores decreased quickly to a level indicating "mild disease" (EASI < 7), and remained low in both countries. However, PROMs showed different trajectories with better scores in Japan.
Conclusion:
Dupilumab showed significant, comparable, and sustained improvement of EASI scores in Japanese and Dutch patients. However, we found striking differences in the effect on PROMs between the countries, with a better outcome in Japanese patients.
