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Mean absorbance IR spectra from pre-processed hyperspectral images of bone marrow biopsies for three histological classes: trabecular bone, collagen (type I) and hematopoietic cells. Arrows indicate optimal features selected using GA-LDA.

Mean absorbance IR spectra from pre-processed hyperspectral images of bone marrow biopsies for three histological classes: trabecular bone, collagen (type I) and hematopoietic cells. Arrows indicate optimal features selected using GA-LDA.

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Figure 2: Collagen deposition grading in bone marrow tissue. From left...
Figure 3: Mean spectra for two classes: trabecular bone and marrow...
Figure 6: Proposed method of imaging. Trabecular bone area measurement...
Figure 10: Mean absorbance IR spectra from pre-processed hyperspectral...
Figure 12: Box plots for spatial features quantifying collagen...
Automated osteosclerosis grading of clinical biopsies using infrared spectroscopic imaging
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  • Jul 2019
Osteosclerosis and myefibrosis are complications of myeloproliferative neoplasms. These disorders result in excess growth of trabecular bone and collagen fibers that replace hematopoietic cells, resulting in abnormal bone marrow function. Treatments using imatinib and JAK2 pathway inhibitors can be effective on osteosclerosis and fibrosis, therefor...
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... Conventional FTIR imaging is therefore used for collagen deposition grading. Since the spectral differences are subtle (Figure 10), BM images are collected at a spectral resolution of 4 cm −1 in reflection mode for collagen deposition grading. ...

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Automated Osteosclerosis Grading of Clinical Biopsies Using Infrared Spectroscopic Imaging
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Osteosclerosis and myefibrosis are complications of myeloproliferative neoplasms. These disorders result in excess growth of trabecular bone and collagen fibers that replace hematopoietic cells, resulting in abnormal bone marrow function. Treatments using imatinib and JAK2 pathway inhibitors can be effective on osteosclerosis and fibrosis, therefor...
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