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Background : The aim of this study was to investigate the correlation between maternal serum homocysteine (Hcy), folate, vitamin B12 (VitB12) and the development of pre-eclampsia (PE).
Methods: Seventy-eight normal pregnant women (without hypertension and proteinuria during their pregnancy (control group)), 66 cases of gestational hypertension (GH...
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Background
Pre-eclampsia is a syndrome that chiefly includes the development of new-onset hypertension and proteinuria after 20 weeks of pregnancy. Pre-eclampsia is one of the major causes of mortality and morbidity in Nepal. Hyperhomocysteinemia may be a cause of the endothelial dysfunction provoked by oxidative stress in pre-eclampsia. This study...
Background and objective
A considerable number of pregnant women who were supplemented with folate and vitamin B12 were selected as major participants in studying the one-carbon metabolic (OCM) pathway. Our study aimed to explore the effects of OCM-related indicators on pregnancy-induced hypertension (PIH) and preeclampsia (PE) in pregnant women wi...
Citations
... Studies have supported a positive association between PE and elevated homocysteine levels. Homocysteine levels are correlated with the severity of PE as well (46,(52)(53)(54)(55). ...
... It has been noted that preeclamptic women experience low levels of folate or vitamins require for metabolizing homocysteine as compare to ones having a healthy pregnancy. During pregnancy the requirement for folate and vitamin increases therefore its deficiency can adversely affect the metabolism of homocysteine (54,55,(72)(73)(74). Genetic factors causative of high concentration of homocysteine has been elaborated in the following. ...
Preeclampsia (PE) presents a major obstetrical problem for mother and fetus which is characterized by the onset of hypertension and proteinuria in formerly normotensive women. Altered folate-mediated one-carbon metabolism is one of the factors for PE development either due to nutritional insufficiencies such as folate deficiency or polymorphisms in genes that code for the key enzymes of the cycle. Commonly, there are four genes in the cycle whose polymorphisms have been described in relation to PE. These factors could cause elevation of homocysteine; the toxic metabolite, which subsequently leads to the development of PE. Sufficient levels of folate have been considered important during pregnancy and may reduce the risk of development of PE. This review aims at discussing genetic polymorphisms and nutritional deficiencies as probable predisposing factors and suggests considering fetal genotypes, varied ethnicities, and interaction of various other factors involved to render better conclusiveness to the present studies.
... 10 Furthermore, a deficiency in maternal vitamin B 12 is associated with adverse pregnancy outcomes such as spontaneous abortion, small-for-gestationalage newborns, low birth weight in newborns, intrauterine growth failure, and neural tube defects. 1 Presently, there is some evidence suggesting that vitamin B 12 levels are lower in women with preeclampsia than in their normotensive counterparts. 11,12 However, there is still a great deal of controversy regarding these findings. On one hand, some studies have demonstrated that vitamin B 12 concentrations are not linked to the development of preeclampsia, 10,13,14 yet on the other hand, several studies have shown the contrary. ...
... It is noteworthy that, on the basis of the inclusion criteria, a limited number of cohort studies that did not report data to distinguish preeclamptic women from women with other pregnancy complications at the time of sampling were excluded from the analysis. 10,[30][31][32] Finally, 19 articles (with 21 case-control studies) 5,6,11,12,[15][16][17][18][19][20][21][22][23][24][25][26][27]33,34 were included in the current systematic review and meta-analysis. Briefly, 16 of these articles reported a significant relationship between serum vitamin B 12 levels and preeclampsia. ...
... Briefly, 16 of these articles reported a significant relationship between serum vitamin B 12 levels and preeclampsia. 5,6,11,12,[15][16][17][18][19][20][21][22]24,25,27,33,34 The articles were published from 1997 to August 2019. ...
Context
Some evidence has shown an association between maternal vitamin B12 levels and the development of preeclampsia in pregnant women, but the relationship between preeclampsia and vitamin B12 is not clear.
Objective
The aim of this systematic review was to compare serum vitamin B12 levels in women with preeclampsia with those in normotensive pregnant women.
Data Sources
The PubMed/MEDLINE, Scopus, and Web of Science databases were searched up to August 2019, along with the reference lists of included articles.
Study Selection
The literature was searched for observational studies that investigated vitamin B12 levels in women with preeclampsia.
Data Extraction
Data were extracted independently by 2 authors. Data were pooled using a random-effects model.
Results
Vitamin B12 levels in women with preeclampsia were significantly lower than those in healthy women (mean, −15.24 pg/mL; 95%CI, −27.52 to −2.954; P < 0.015), but heterogeneity between studies was high (I2 = 97.8%; P = 0.0103). Subgroup analyses based on folic acid supplementation, homocysteine concentrations, and gestational age at the time of sampling for vitamin B12 assessment did not identify the sources of heterogeneity.
Conclusions
Women with preeclampsia had significantly lower vitamin B12 concentrations than normotensive pregnant women.
... Folate is involved in intracellular metabolism , as well as DNA synthesis and repair, and it is an essential factor for both normal and tumor cells [18][19][20]. FOLR1, a membrane protein with a molecular weight of 38-40 KD, easily binds oxidized folate, which is not expressed in normal cells, but is expressed by a large number of nonmucinous epithelial tumor cells (such as epithelial ovarian cancer cells). However, the mechanism responsible for this high expression of FOLR1 in tumor cells is still unclear [21][22][23]. ...
Objective To investigate folate-receptor 1 ( FOLR1 ) expression in ovarian cancer and its association with patient prognosis.
Methods TCGA and Oncomine databases were used to collect data about FOLR1 mRNA expression in multiple carcinomas. FOLR1 mRNA expression levels in ovarian cancer samples and corresponding adjacent normal ovary tissue were compared. A protein-protein interaction (PPI) network was constructed using the STRING database of FOLR1 and relevant genes. The overall survival (OS) and progression free survival (PFS) rates of ovarian cancer patients in high- and low- FOLR1 expression groups were compared by log-rank test. Sixty-six ovarian epithelial carcinoma samples were included in the study, and tumor specimens of the 66 cases were tested for FOLR1 protein expression by an immunohistochemistry assay.
ResultsFOLR1 mRNA was significantly elevated in ovarian cancer compared to other carcinomas. FOLR1 mRNA expression levels were significantly higher in tumor tissues than in the corresponding normal tissues (P<0.05) of ovarian cancer patients. The PPI network indicated that the local clustering coefficient was 0.898, indicating that the PPI network was enriched significantly (P<0.05). The median PFS values were 22.39 and 19.00 months for lowand high- FOLR1 expression groups, respectively, with significant statistical difference between the two (HR=1.26, 95%CI:1.09-1.45, P<0.05). FOLR1 protein expression was correlated with tumor differentiation (P<0.05) in ovarian cancer patients. However, its levels were not correlated with patient age, tumor diameter, lymph node metastasis or FIGO stage (P>0.05).
ConclusionFOLR1 is upregulated in epithelial ovarian cancer, and its expression is correlated with patients’ progression free survival, making it a valuable biomarker for prognosis.
