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In this work modeling and analysis of an integrated opto-fluidic sensor, with a focus on achievement of single mode optical confinement and continuous flow of microparticles in the microfluidic channel for lab-on-a-chip (LOC) sensing application is presented. This sensor consists of integrated optical waveguides, microfluidic channel among other in...
Similar publications
In this work modeling and analysis of an integrated opto-fluidic sensor, with a focus on 8 achievement of single mode optical confinement and continuous flow of micro particles in the 9 microfluidic channel for Lab-on-a Chip (LOC) sensing application is presented. This sensor consists 10 of integrated optical waveguides, microfluidic channel among...
In this paper, we design and optimize a single-mode photonic crystal (PhC) nanobeam-grating (NBG) structure with antisymmetric quarter-elliptical walls geometry based on the computational finite element method (FEM). This structure is capable of providing a wide bandwidth spectrum for chemical sensing (ChS) operation due to the 2∆λ ≈ 110 nm wide ba...
In recent years, advancements in micromachining techniques and nanomaterials have enabled the fabrication of highly sensitive devices for the detection of odorous species. Recent efforts done in the miniaturization of gas sensors have contributed to obtain increasingly compact and portable devices. Besides, the implementation of new nanomaterials i...
Citations
... Figures 9-11 shows the pressure, temperature and velocity of fluid distribution for the inlet pressure of 1 Pa relative to increase in temperature of 290 K to 300 K [45]. Velocity of fluid movement from one closed chamber to other varies from 0.002 m s −1 . ...
This research encompasses a comprehensive study on the application of 1D photonic crystal-based detection in the context of infectious diseases, specifically targeting malaria stages, chikungunya, and dengue. It explores the interactions between the photonic crystal and various biomolecules associated with these diseases, with a focus on platelets, plasma, and uric acid. The transmission spectrum graphs obtained from these interactions provide crucial insights into the detection and quantification of the diseases, offering real-time and label-free monitoring capabilities. Maximum sensitivity of 550nm/RIU and Q factor of 29,260 obtained. Additionally, the study incorporates the design and analysis of a microfluidic channel optimized for the proposed sensor, ensuring accurate temperature and pressure distributions. The results demonstrate the feasibility of the microfluidic platform for enhancing sensor performance and fluid handling. This integrated approach shows promising potential for early disease diagnosis and monitoring, paving the way for practical implementation and further advancements in the field of sensing and diagnostics
... The results obtained can be used to detect many pathological parameters to treat many diseases and to know nature of sample. This type of optical sensors with fluidic gap finds applications in human health monitoring and medical applications [4][5]. ...
... The absorption coefficient of graphene with The intensity of mode coupled to output waveguide depends upon the gap between the waveguides, as shown in Figure 5.1. Equation (5.2) gives mathematical relationshipbetween modes coupled between waveguides[4,29]. ...
... 4 shows the complete optofluidic sensor parameters. The sensitivity of ~1.67 × 10 −6 RIU reported in this work is almost comparable to earlier reported works ...
The research work described in this thesis gives complete details on analysis and modeling of two different optofluidic integrated devices designed to operate at 1550nm and 1310 nm respectively. In the first device, modeling, simulation and analysis of an optofluidic device for lab-on-a-chip applications is carried out. It consists of integrated single mode silicon-on-insulator waveguides, and micro-fluidic channel consisting of a narrow fluidic-channel between two sealed fluid chambers. The effective index for complete sensor is found to be 2.3. Optical loss of 0.057 dB/m. Sensitivity of 1.67 × 10−6 RIU is reported. This work is published in journal of Micromachines.
In the second device, mathematical modeling, simulation, analysis and development of silicon on insulator grating coupler opto-fluidic biosensor for lab- on-a- chip applications is presented. This device is composed of integrated components such as microfluidic channel and SOI grating coupler. The structure of the microfluidic channel is molded on the gratings. The investigation on achieving continuous fluid flow, optimizing injection angle and coupling power is carried at a wavelength of 1310 nm. The rectangular microfluidic channel with periodic gratings at the center is considered for fluid flow analysis. Pressure driven fluid flow is reported and fluid flow is profile is parabolic. This work reports ~55.2 % a maximum of coupled power at 14.1° of launching angle. The effective index of 2.806 is estimated for SOI grating coupler with fluidic channel having 1.334 refractive index of fluid sample. Flow rate of 15.6 μL/s, with sensitivity of 0.928 × 10−6 RIU is reported. Fabrication process steps are shown for integrated SOI optical gratings based biosensor. This work is published in photonics journal.
Further the work is carried out on optimization of gratings dimensions and compact taper for coupling of light to single mode SOI waveguide. An attempt to reduce the losses in SOI optofluidic devices at visible wavelength by using graphene on silicon is also discussed. The various devices with different gap distances are fabricated and details of fabrication process are presented in the thesis. The fabrication of opto-fluidic sensor is carried out at CeNSE, IISc- Bangalore.
... The physical and chemical properties of PDMS also make it possible for the fabrication of devices from molecular analysis to frequency tunable lasing [3]. Biosensors on SOI substrate are proposed in the recent developments in SOI sensors [4][5][6] are suitable at infrared wavelength. In the work reported in this paper can be used for sensing applications at visible wavelength. ...
... The structure proposed in this work can be used as fluidically tuned PC for bio-sensing applications after placing a fluidic channel on top of the PC. The sensitivity is based on refractive index and absorbance based sensing as suggested in literature papers [4][5][6]. ...
In this work, silicon nitride (Si3N4) based fluidically tuned photonic crystal for a biosensing
application is presented. The optical structure is designed on Si3N4 on insulator.
The Si3N4 on insulator substrate is found to be one of the most promising materials for
the design of bio- sensor at short wavelength. At short wavelength Si3N4material is found
to be most promising material for optical integrated circuits. The structure of the sensor
consists of Silicon nitride input and output waveguides separated by a fluidically tuned
photonic crystal. Fluidically tuned photonic crystal acts as a sensing region. The
sensitivity is based on refractive index of fluidically tuned photonic crystal. The
proposed sensor is designed to operate in the visible wavelength range of 660nm.
Fluidically tuned photonic crystal consists of rectangular photonic crystal array. The
holes of photonic crystal are approximately 160nm in diameter and height is 200nm.
Organic light emitting diode is used as an optical source. OLED is coupled to input
waveguide. The PDMS microfluidic channel is moulded on the rectangular photonic
crystal structure. The structure is modelled and analysis is carried out by using Lumerical
mode solution and Lumerical Finite Difference Time Domain (FDTD) simulation tools.
Such devices if fabricated can be employed for early detection of various diseases related
to pathological parameters.
... The sensitivity was found to be 0.928 × 10 −6 RIU. Such sensors, if fabricated, can be effectively used as lab-on-chip biosensors [23]. Such SOI gratings coupled with a microfluidic channel can be effectively used as absorbance-based and refractive index-based biosensors for point-of-care diagnostics. ...
The design, modeling, and analysis of a silicon-on-insulator (SOI) grating coupler integrated with a microfluidic channel for lab-on-a-chip applications are presented. The grating coupler was designed to operate at 1310 nm. The simulated SOI structure consisted of a 220 nm top-Si device layer with an integrated waveguide, grating coupler, and a buried oxide layer of 2 µm. A rectangular microfluidic channel was deposited on the SOI optical grating structure for light and fluid interaction. The fluidic flow through the device was driven by centrifugal and Coriolis forces. The grating structure was designed to achieve a maximum coupling efficiency at the optimized injection angle of the light source. The sensitivity of the grating structure could be analyzed and evaluated using the change in coupled power as a function of the effective refractive index and was found to be 0.928 × 10−6 RIU. The SOI optical grating structure along with the micro fluidic channel on top could be effectively used as an absorbance-based lab-on-a-chip biosensor.
... Brag grating sensor and waveguide with energy patterned on substrate was used [23][24]. A Lab-On-a-Chip device with microfluidic channels for detection of the solvent are used in the medical application [31][32][33][34]. ...
