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![Man partial karyotype by GTGbanding [ 46,XY, t(5;11)(q32;q24.2) ]. Arrows indicate the breakpoints.](profile/Dogan-Binici/publication/45492700/figure/fig1/AS:347120369455107@1459771353956/Man-partial-karyotype-by-GTGbanding-46-XY-t511q32q242-Arrows-indicate-the.png)
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Situs inversus viscerum is a condition in which the organs of the chest and abdomen are arranged in a perfect mirror image reversal of the normal positioning. The condition is in about 1 in 8,500 people. Although the mechanism that causes the heart loop to go left is not fully understood, it is thought that many factors are involved. Here we report...
Context in source publication
Context 1
... case was 35 years old. His heart was on the right (dextrocardia), his liver was on the left, and his spleen was on the right. Cytogenetic study showed that the man carried a balanced reciprocal translocation: 46,XY, t(5;11)(q32;q24.2) (Fig. 1). He had no dysmorphism, but he had chronic gastritis and chronic esophageal acid reflux. The family history was unremarkable. In the imaging studies, a computerized to- mography (CT) demonstrated dextrocardia with a structurally normal heart (Fig. 2). An abdominal magnetic resonance graphy (MRG) de- monstrated visceral situs inversus ...
Citations
... Though the exact mechanism of the abnormal heart tube orientation and development is not fully understood there are documented linkages to chromosomal abnormalities (balanced reciprocal translocation t(5;11)(q32;q24.2), [6] and microdeletion of chromosome 2q37.3, [7]). ...
Introduction: Situs Inversus Totalis is a rare congenital condition with an autosomal recessive inheritance. Most of the people with SIT are asymptomatic, making its diagnosis a challenge. Although many cases of cancers co-existing with SIT have been reported in medical literature, the co-existence of RCC with SIT is extremely rare. We are presenting the 5th reported case in the published medical literature
Case report: We report a case of a 65 year old male who presented with intractable back pain, difficulty in performing daily activities and unintentional weight loss. Evaluation of these symptoms revealed SIT, a right renal mass and widespread metastatic deposits. Immunohistochemical analysis confirmed the diagnosis of clear cell type of renal cell carcinoma.
Conclusion: Situs Inversus is a rare congenital abnormality which may be associated with renal anomalies, Kartagener syndrome, and several types of malignancies. Further study is needed to characterize the genetic basis of SI and establish whether there is a causal basis between SI and the development of malignancy.
