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Multiple Myeloma involving the breast is very rare and the diagnosis is challenging because the clinical and radiological features of breast multiple myeloma are indistinguishable to other forms of breast disease whether primary or metastatic. In this article the authors report a case presented with breast masses, which were found to be extra osseo...
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Background
Breast cancer is the most prominent cause of women's mortality due to cancer and is one of the most serious and commonly diagnosed cancers among Iranian women. Also, social support plays a vital role in breast cancer patients' lives and their diagnosis and treatment processes. This study aimed to determine the associations between social...
Background: There is no generally accepted standard radiological approach to
male breast diseases. Ultrasonography and mammography are the most preferred
methods for imaging. The purpose of this study is to investigate the diagnostic
performances of only single-view (mediolateral oblique) mammography and
routine two-view mammography in the male bre...
BACKGROUND
Multidisciplinary team (MDT) discussions are widely held to facilitate the diagnosis and treatment of breast cancer, but patient compliance with the MDT recommendations and the impact of compliance on disease outcome are uncertain.
METHODS
We conducted a retrospective review of data from a prospective database of breast cancer patients...
Background
Breast tuberculosis, also known as tuberculous mastitis, is an extremely rare form of tuberculosis. It accounts for <0.1% of all breast diseases and <2% of all cases of tuberculosis. It is often misdiagnosed as breast cancer, which can potentially lead to a delayed diagnosis.
Case presentation
A 69-year-old Japanese woman presented with...
The anatomic and histologic characteristics of the nipple-areolar complex make this breast region special. The nipple-areolar complex can be affected by abnormal development and a wide spectrum of pathological conditions, many of which have unspecific clinical and radiological presentations that can present a challenge for radiologists. The nipple-...
Citations
... In addition, IM can occur from other, rarer primaries. Since 2016, rare primaries described in the literature have included bladder cancer [43][44][45][46], orbital rhabdomyosarcoma [47], skull base chordoma [48], mesothelioma [49,50], thymic epithelial tumor [51], squamous cell carcinoma (SCC) of the hand [52], salivary duct cancer [53], combined hepatocellular carcinoma-cholangiocarcinoma [54], mediastinal neuroblastoma [55], ureteral cancer [56], appendiceal adenocarcinoma [57], synovial sarcoma [58], choriocarcinoma [59], multiple myeloma [60], uterine serous carcinoma [27], and Wilms' tumor [40]. 1 a) 69-year-old female with history of lung cancer with new mass seen on screening mammogram. Diagnostic mammogram (i) and ultrasound (ii) images. ...
Purpose of Review
Metastases to the breast (intramammary metastases, IM) from extramammary malignancies (EM) are uncommon. As prognosis is poor, timely diagnosis is key to direct patients towards appropriate treatment. We will review recent literature regarding the epidemiology, presentation, and diagnosis of IM.
Recent Findings
IM commonly present as palpable masses, with imaging findings often based on hematogenous versus lymphatic spread. While many IM are diagnosed with a history of EM, IM may also be the first presentation of distant metastatic disease. In most cases, immunohistochemical testing is required to differentiate between primary breast cancer (PBC) and IM.
Summary
Recent research, focused on immunohistochemical markers, can guide diagnosticians in differentiating IM from PBCs. Key factors to consider when diagnosing any breast mass include a prior history of cancer, imaging characteristics, histologic findings that are atypical for PBCs, and the immunohistochemical profile of each lesion.
... The probability of malignant transformation of IgM-MGUS is significantly higher than that of non-IgM-MGUS; and (3) Light chain MGUS involves a monoclonal protein lacking immunoglo-bulin heavy chain components. Light chain MGUS can progress to light chain multiple myeloma (risk 0.3%) and immunoglobulin light chain amyloidosis [7,8]. ...
Background:
Infiltrating ductal breast carcinoma with monoclonal gammopathy of undetermined significance (MGUS) is rare and easily misdiagnosed. Most patients are first diagnosed with MGUS. We report a rare case of MGUS secondary to infiltrating ductal breast carcinoma. We also review the literature to analyze the clinical characteristics and diagnostic methods.
Case summary:
A 51-year-old woman underwent modified radical mastectomy for infiltrating ductal carcinoma of the right breast and was then treated with radiation and chemotherapy. A decreased platelet count was found on routine blood examination, and MGUS was subsequently diagnosed. This is the first report of the occurrence of MGUS after breast cancer surgery.
Conclusion:
Vigilance is required to distinguish this rare comorbidity from breast plasmacytoma.
... 14 Meanwhile, the imaging manifestations of MM involving breast or superficial soft tissue alone have only been reported in individual cases. 17 Due to the same pathological origin, MM and primary plasmacytoma of the breast may have similar imaging manifestations. Surov A reported that MM of breast appeared as a hypoechoic or heterogeneous mass, which may be well-circumscribed and microlobulated, or ill-defined and lobulated. ...
Multiple myeloma (MM) in the breast has been rarely documented. However, there are no reports on concurrent masses of chest wall soft tissue and breast as the primary symptoms for MM. Herein, we report a case of a 68-year-old woman presented with masses in her right breast and chest wall for 1 month. She recalled having xerophthalmia and xerostomia for 2 years without taking any test to search for the cause of these symptoms. Ultrasonography (US) and computed tomography (CT) examination revealed masses in the right breast and chest wall. Both lesions of the breast and chest wall were confirmed to be plasma cell tumors by ultrasound-guided puncture biopsy and MM was confirmed by bone marrow examination. Meanwhile, Sjogren's syndrome (SS) was diagnosed by the positive expression of antibodies against antinuclear, Ro/SSA and La/SSB. After three courses of chemotherapy for MM, the symptoms of SS were significantly alleviated and the masses in the chest wall and breast disappeared.
Multiple myeloma is a malignant plasma cell condition that mostly affects the skeletal system and bone marrow. Pleural effusions are uncommon and typically result from other conditions coexisting with multiple myeloma. Malignant myelomatous pleural effusions are rare complications of multiple myeloma, occurring in less than 1% of patients and are associated with poor prognosis having mean survival of less than 4 months. The present case report is a 41-year-old multiple myeloma patient who developed bilateral pleural effusion at a disease relapse. Chemotherapeutic regimen of cyclophosphamide, bortezomib, and dexamethasone given. Despite a positive response to treatment, the patient’s condition worsened over the course of following month and he eventually passed away. Myelomatous pleural effusion indicates poor prognosis and early consideration helps in quick diagnosis and initiation of treatment which may help in improving prognosis.
Multiple myeloma (MM) involving the breast tissue is rare. We report the case of a 70-year-old woman with a background of previously treated MM in remission presenting with a breast lump. Histology showed a plasma cell neoplasm and subsequent staging investigations showed widespread extramedullary relapse of MM. Despite its rarity, this diagnosis should be considered within the differential diagnosis of breast masses as it can arise de novo or may be the first presenting feature of myeloma. The importance of the multidisciplinary team approach with triple assessment of the breast, as well as recent advances in knowledge regarding extramedullary disease in myeloma and novel treatment approaches in MM are discussed.
