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Background:
Recurrent aphthous ulcerations are common benign ulcerated lesions on the mouth, whose etiology is poorly understood, with controversial treatment and difficult to control in clinical practice.
Objective:
To evaluate the cases of recurrent aphthous ulcerations with a focus on treatment, diagnosis and etiology.
Methods:
This is a re...
Context in source publication
Context 1
... the clinical follow-up of the patients, the majo- rity (88%) reported improvement with the treatment prescribed at the time of the diagnosis of the condition, even with relapsing epi- sodes. Figures 2 and 3 belong to a RAS case treated with clobetasol propionate 0.05% (rinses of 10 ml for one minute, three times a day for 15 days). ...
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Oral mucosal diseases are concerns to specialists across multiple disciplines, such as family physicians, dentists, dermatologists, and otorhinolaryngologists. Geographic stomatitis is defined as slightly raised, round, erythematous lesions that are restricted by well-defined whitish borders. The etiopathogenesis of this condition is unknown. There...
Background: Dental erosion is defined as irreversible loss of hard dental tissues as a result of the action of endogenous and exogenous acids of non-bacterial origin. Its severity and extent depend on different behavioural factors.
Aim: This study examined the relationship between oral hygiene habits and the presence of dental erosion in children...
Citations
... The majority of recurrent aphthous ulceration in the oral cavity have been found an extreme variation regarding sites in which Queiroz and his collegues found that the majority of RAS lesions were located in the tongue (28) , Chatterjee's study showed lower vestibule was the main site and Oyetola's finding was lower lip (29,30) , while this study found that the lower lip where the most site affected by RAS (47%), Therefore, the relation between RAS and site was mostly variable from study to another which could be related to the differences in samples of the population selected on each one. ...
... In the present study, the circulating irisin was correlated with BMI and found positive non-statistical significant relation, this result comes to agree with previous studies (28)(29)(30) while it does not agree with others (19,20) , thus, other studies with a larger number of sample consisting of different subjects are guaranteed in future to investigate the definite association of irisin with BMI. ...
Background: Recurrent aphthous stomatitis remains the most common ulcerative disease of the oral mucosa that exists as painfull round shallow ulcers with a well-defined erythematous margin and a yellowish grey pseudomembranous centre. Salivary irisin is an identified adipomyokine and research has revealed that it has an anti-inflammatory effect and is a novel myokine; it is synthesized in skeletal muscle and adipose tissue. The aim of the present study was to evaluate the relation of salivary irisin to recurrent aphthous ulcers and weight status in Diyala City / Iraq. Materials and methods: A cross-sectional comparative study was carried out during the period from the end of December (2021) until the end of March (2022). The total sample size composed of all patients attending a specialised dental center in Ba’aquba / Diyala governorate with recurrent aphthous ulcers of both gender and ages ranged from 20-30 years (100 patients consider the study group) assessed according to the directions suggested by the WHO (1997) and compared to the control group free from this lesion (100 patients consider the control group) matching in age and sex. The weight status was assessed using the digital weight scale. The sub samples of 45 from each study and the control group were selected to analyse salivary irisin. The description of data, presentation, and analysis process is carried out through the use of the SPSS package (SPSS version 22, Chicago, Illinois, USA). For the quantitative variable mean, the standard deviation (SD) was used. Frequency and percentage are used for the qualitative variable. The independent sample T test was used for the difference between the two groups. Pearson’s correlation was used for the linear correlation between two quantitative variables. Results: The highest percentage of recurrent aphthous ulcer was found in the lower lip. The mean value of irisin was higher among the study group than in the control group. The mean value of the body mass index among the control group was higher than that of the study group. When correlating the body mass index with salivary irisin, it is a positive weak not significant correlation. Conclusions: This study concluded that there is an elevated level of irisin among recurrent aphthous ulcers, in addition to that, the recurrent aphthous ulcer decreases the body mass index.
... The weight difference limit of the drug-loading film samples conformed with the provisions. According to the method for determining the dissolution time limit for the clotrimazole oral film in the Chinese Pharmacopoeia, 2020 edition (Queiroz et al., 2018), the drug-carrying film with the optimal ratio was cut into six films that were each 1 cm 2 and then clamped with two layers of stainless steel wire with an inner diameter of 2.0 mm. All films should be dissolved and go through the screen within 15 min, according to the method for the determining the disintegration time limit of tablets (general rule 0921). ...
Background: Cod liver oil has anti-inflammatory properties and could help regulate recurrent aphthous stomatitis (RAS). An orthogonal experiment was used to evaluate and improve the dosage form of compound cod liver oil, which has replaced the previously used liniment preparation based on film method.
Methods: An orthogonal experiment was adopted, and the appearance and film-forming time of the film coating agents were used as indicators. The optimal ratio in the preparation process for the compound cod liver oil film agent was then optimized. A method for determination of compound cod liver oil film was established using High-Performance Liquid Chromatography (HPLC).
Results: The results indicate that the blank films prepared using 55 mg polyvinyl alcohol (PVA) (PVA low), 45 mg of PVA (PVA medium), and 10 mg glycerol had the optimal performance, which was defined as PVAa. The drug-carrying film prepared from 3 mL PVAa (i.e., film-forming material with the optimal proportion), 30 mg dexamethasone acetate, and 30 mg metronidazole had the optimal performance. The verified sample has a complete and smooth appearance, uniform thickness and color, and no evident bubbles, which meets the requirements for a film agent defined in the Chinese Pharmacopoeia, 2020 edition. HPLC was used to determine the major components: dexamethasone acetate, metronidazole, and dyclonine hydrochloride, and the optimal separation effect was obtained. The method has advantages of good specificity, good linear results, high recovery rate, and good repeatability.
Conclusion: This study proposes an optimized compound cod liver oil film former agent and preparation method. The results indicate that the compound cod liver oil film former agent had good performance, reflecting the high feasibility of this research method. The detection method of compound cod liver oil film was established by HPLC. The method was feasible, and the validity and stability of the formulation and preparation technology were guaranteed. The role of the newly developed agent in patients with RAS should be investigated further.
... Research by Chiang and their team has shown that IL-8 levels in the oral fluid of patients suffering from aphthous ulceration are significantly higher than those in healthy individuals [13]. Their findings advocate for the effectiveness of using saliva samples for detecting increased cytokine levels in aphthous ulceration, suggesting that salivary IL-8 is a dependable indicator for evaluating the disease's severity. ...
Background: Aphthous ulcers (AU) and Rheumatoid Arthritis (RA) are conditions marked by inflammation, with Interleukin 8 (IL-8) playing a significant role in their pathogenesis. This study aims to evaluate the levels of IL-8 in saliva among individuals with AU, RA, both conditions and healthy controls, providing insights into its potential as a diagnostic biomarker and therapeutic target. Methods: The study, endorsed by the Ethics Committee of the University of Kufa, College of Dentistry, Department of Oral Pathology, employed a descriptive, analytical, and cross-sectional approach. Participants included patients with AU, RA, both conditions and a control group, totalling 94 individuals. Exclusion criteria encompassed medication use, other systemic conditions, and lifestyle factors like smoking. Saliva and blood samples were collected for IL-8 concentration measurement using ELISA and for Rheumatoid Factor (RF) and anti-CCP analysis. Results: Analysis showed the highest average salivary IL-8 levels in patients with both AU and RA (483.33 ± 141.20 pg/mL), followed by the RA group (338.57 ± 79.11 pg/mL), the AU group (381 ± 108.48 pg/mL), and the control group (213.69 ± 84.65 pg/mL). Significant differences in IL-8 levels were observed between these groups, with the combined AU and RA groups showing the highest concentrations. However, the variation in IL-8 levels between those who have both AU and RA and those with only RA was not statistically significant. Conclusion: The study highlights a distinct elevation in salivary IL-8 levels in patients with AU and RA, particularly in those suffering from both conditions.
... A plethora of causative factors have been linked to the occurrence of RAS, including genetic tendency, hypersensitivity, immunological, nutritional, and microbial variables [3]. Moreover, RAS has been proposed to be associated with stress and anxiety, which impact the immune system components [4]. ...
Objectives: Recurrent aphthous stomatitis (RAS) is one of the most common oral mucosal lesions and stress is one of the major factors implicated in its causation. The aim of the present work is to measure the stress biomarkers, salivary cortisol (SC) and salivary alpha amylase (SAA), in the different phases of RAS. Patients and Methods: The study included 69 subjects of whom 38 patients served as the study group who suffered from minor RAS and one to three active minor oral ulcers of <48 h duration. The remaining 31 healthy subjects served as controls. Unstimulated salivary samples were collected twice from the study group; during the ulcerative phase of RAS and after complete healing has occurred, and only once from the controls. Concentrations of SC, and SAA enzyme were assessed by Enzyme-linked Immunosorbent Assay (ELISA). Results: There was a significant increase of SC and SAA in both the ulcerative and the post-healing phases in comparison to the control group. The ulcerative phase had higher but insignificant levels of both biomarkers when compared to the post-healing phase. There was a significant correlation between both biomarkers in the post-healing but not in the ulcerative phase. Conclusion: RAS patients have significantly higher levels of both stress biomarkers (SC and SAA) in the ulcerative and in the post-healing phases when compared to controls.
... Cooke (1969) classified the lesions of RAS into three groups, and Lehner (1968) characterized them from a study of 210 patients. Considering the clinical features, three main types of recurrent aphthous stomatitis can be defined: Minor aphthae (most common), representing 70%e85% of all RAS patients, are also referred to as Mikulicz's aphthae (MiRAS), major aphthae (Sutton's aphthae; MaRAS), which are less common with a rate of 7%e 20% of the cases, and herpetiform aphthae (HeRAS), which are rare and present as groups of pinpoint ulcers in 5%e10% of RAS ( Slebioda et al., 2013;Queiroz et al., 2018). RAS may be associated with other systemic disorders, including Ulcus vulvae acutum, behçet's disease, MAGIC syndrome, FAPA syndrome, cyclic Neutropenia, aphthous-like ulcerations of HIV disease, and hematinic deficiencies Celiac Disease (sprue, gluten-sensitive enteropathy), Inflammatory bowel disease (Rogers, , 1997). ...
Background: The mouth is a unique and intricate structure composed of various anatomical components that work together effectively to perform various functions. The oral cavity can be affected by various disorders, such as genetic diseases, infections, and metabolic disorders.
A wide range of genetic disorders can affect the skeletal system, including craniofacial structures and teeth. These disorders exhibit a significant variety in terms of their causes when they show up, and how severe they are. Genetics is a significant risk factor in the development of oral diseases. It affects the pattern of inheritance, which can be dominant, recessive, or both. The transmission of genetic variation from one generation to the next is a significant contributor to the development of various diseases, having both direct and indirect impacts.
Objective: Our study seeks to shed light on the genetic causes and symptoms of diseases that affect bone and mucosal tissues. We will also investigate the associated symptoms and explore the various diagnostic and treatment options available for these specific genetic disorders.
Conclusion: The scientific study of oral genetic disorders is still in its early stages, and further research is necessary to improve diagnostic, prognostic, and treatment methods.
... This study's results align with research conducted by Queiroz et al. and Shirzaiy et al., which states that it is most common to find patients who experience RAS Minor around 70-85% in a specific population. 24,25 Major RAS is rare, with a general prevalence of Major RAS of 7-20% per case, and herpetiform RAS is less common. 24 The quality of life of RAS patients was measured based on the SF-36 questionnaire. ...
... 24,25 Major RAS is rare, with a general prevalence of Major RAS of 7-20% per case, and herpetiform RAS is less common. 24 The quality of life of RAS patients was measured based on the SF-36 questionnaire. The results of this study indicate that most RAS patients have a good quality of life (62.5%). ...
Background: Recurrent Aphthous Stomatitis (RAS) is an ulcerative disease in oral mucosa. These lesions are usually located on the non-keratinized oral mucosa with the characteristics of recurrent ulcerated lesions and the presence of pain. Some people affected by RAS will have various impacts on speech, swallowing, and chewing functions. Patients with RAS usually experience pain, and this impact greatly affects their quality of life. Objective: This study examined the relationship between RAS and patients' quality of life. Materials and Methods: This study is a cross-sectional observational study. The method of taking the subjects was done using consecutive sampling with 32 subjects. Data collection was carried out with objective and subjective data. Results: A significant relationship exists between RAS and patient quality of life p = 0.044 (Fisher's Exact Test,p0.05). There is a significant correlation between RAS and patient quality of life Spearman's correlation test, significance p0.05) with a value of p = 0.018 with a strength level of a correlation coefficient of 0.415, which means that it has a moderate level and a direction of the correlation is positive. Conclusion: Aspects of social functioning limitation and bodily pain are most influenced by the emergence of RAS lesions. There is a positive correlation between RAS and patients' quality of life.
... Поширеність, висока частота та погіршення якості життя, спричинені ХРАС, викликали значну кількість досліджень етіології та ефективної терапії цього захворювання [6,7]. Однак, етіологія ХРАС все ще залишається нез'ясованою, а наявна на сьогодні терапія -недостатньою. ...
Actuality: The prevalence, high frequency and deterioration in quality of life caused by chronic recurrent aphthous stomatitis have led to a significant number of studies of the etiology and effective therapy of this disease. However, the etiology of chronic recurrent aphthous stomatitis is still unclear and the currently available therapies are insufficient. Purpose: to study the clinical and pathogenetic features of chronic recurrent aphthous stomatitis. Materials and methods: The study included 80 patients: 29 men (36.25%) and 51 women (63.75%) with CRAS who sought help at the Department of Therapeutic Dentistry of the Bogomolets National Medical University. The age of the study participants was from 19 to 55 years. Patients with CRAS were divided into two groups: the first group (n=35) without gastrointestinal diseases, the second group (n=45) with gastrointestinal pathology. The control group (n=20) consisted of patients with diseases of the oral mucosa. To study the spectrum and number of microorganisms, biological material was taken from the surface of aphthous elements and PCR testing was performed (Diagen laboratory, Kyiv). The concentration of blood haemoglobin, iron, vitamin B 12, folic acid in the blood was determined using tests performed in the Diagen laboratory, Kyiv. Statistical analysis was performed using the licensed package MedStat 12 and Microsoft Excel. Results: In patients with gastrointestinal diseases (chronic gastritis and duodenitis, chronic pancreatitis), the most common recurrence of aphthae is 2 times per year, and in patients without gastrointestinal pathology, the most common recurrence of aphthae is 1 time per year. The results of the PCR study showed that in almost all clinical groups of patients examined, in samples taken from the surface of the aphthae, microorganisms of the genus Streptococcus and Staphylococcus were detected in 91.8% of cases, and Lactobacillus spp. were isolated in 51.4% of cases. Patients with CRAS had a significantly higher incidence of haemoglobin, iron, vitamin B12 and folic acid deficiency than patients in the control group. Conclusion: When recurrent oral aphthae are detected, it is advisable to conduct an examination by a dentist and a gastroenterologist to identify the presence of gastrointestinal diseases in patients. There is a significant association of haemoglobin, iron, vitamin B12 and folic acid deficiency with CRAS. Key words: chronic recurrent aphthous stomatitis, gastrointestinal pathology, microbiome, blood parameters.
... Remarkable side effects are among important reasons causing insufficiency in the current therapeutic approach in the field of dental medicine 33 . In a systematic review on 25 randomized clinical trials assessing the pain reduction linked with RAS or decrease in pain duration, the rate of side effects was small 34 . ...
Recurrent aphthous stomatitis (RAS) is recurrent and painful diseases of the oral mucosa that can be very painful and annoying despite their small size. There is no definitive cure for this disease and the usual treatments are mainly based on pain control. The aim of this study was to investigate the effect of honey-lemon spray (mucotin) in the treatment of recurrent aphthous stomatitis. Methods: This study is a randomized controlled clinical trial conducted in 2020 at Zahedan University of Medical Sciences on 46 RAS patients. The participants were randomly assigned to the intervention (mucotin) or control groups (Triamcinolone ointment) equally (23 patients in each group). Patients were evaluated for the severity of pain and ulcer size. Evaluations were performed on days 0, 2, 7 of the treatment using VAS. Data were analyzed using ANOVA statistical test. Results: The inner aspect of the lower lip was the most common site of RAS in the participants (48.8%) and the lowest site went for hard palate (2.4%). Four items including pain, burning sensation, necrosis area, and erythematous area were evaluated in both groups. There was no significant difference in all parameters before the treatment period (day 0). The mean pain score, burning sensation, necrosis, erythematous areas were not different in days 0, 2 and 7 between groups respectively (p=0.849, p=0.105, p=0.917, p=0.442). Conclusion: Honey-lemon spray (Mucotin) and topical corticosteroid have similar effects in RAS treating, So Mucotin can be used as the first line of treatment for RAS lesions. This herbal medicine has no side effects.
... The annual prevalence of aphtha was found to be 10.84 % in Turkey on 2325 subjects 20-87 years in 2016 with higher levels in women and young adults (Baş et al., 2016). In a retrospective study in Brazil in 2018, for a period of 11 years, among 4895 patients 3.3 % had complaints of oral aphthous ulcerations (Queiroz et al., 2018). In the study of Davatchi et al in 2008 on 10,291 subjects in Iran, 25.2 % had aphthosis ulcers at some time in the present or past with a higher prevalence in women (Davatchi, et al., 2008). ...
Oral health status can be affected by some factors including drug abuse, systemic conditions and environmental pollutants. The present study was designed to investigate the most important and prevalent dental and oral conditions in adult population of Rafsanjan with the age of 35–70 years. Dental and oral health cohort center as part of the Rafsanjan Cohort Study (RCS) included in the prospective epidemiological research studies in IrAN was established in 2015. Of 9991 subjects enrolled in the RCS, 8682 people participated in the Oral Health Branch of Rafsanjan Cohort Study (OHBRCS).
The OHBRCS included 4021 men and 4661 women with the mean age of 49.94 ± 9.51. The most prevalent of oral lesion in total population was candidiasis and the least was aphthous lesion. The prevalence of candidiasis, white and red lesions, periodontal pocket, dental calculus, CAL and the mean of DMFT were higher in the male group than that of female group (p < 0.05). Candidiasis, herpes, oral cancer, white and red lesions were more prevalent in the older age groups (p < 0.05). The mean of DMFT index in total population was 21.30 and was higher among opium users, men and older age (p < 0.05). Also, the opium users had a higher rate of CAL, periodontal pocket, red and white lesions, and candidiasis but a lower rate of BOP (p < 0.05). Younger people had more decayed and filling teeth compared to other age groups, whereas older people had more missing teeth and a higher DMFT index (p < 0.001).
... El diagnóstico es clínico, basado en la historia médica y examen clínico para diagnóstico diferencial con lesiones neoplásicas orales y/o otras enfermedades bucales ulcerativas 7,8 . ...
... El tratamiento de la sintomatología se ha orientado en la aplicación local de anestésicos tópicos, antiinflamatorios no esteroideos (AINES) y/o corticosteroides 8,9 . ...
La estomatitis aftosa recurrente (menor, mayor o herpética) es una de las enfermedades bucodentales más frecuentes, de etiología multifactorial y con predisposición genética. Para esta patología su diagnóstico es clínico, y tomando como base la historia clínica se puede discriminar con otras patologías ulcerativas. La terapia con láser de baja potencia (LLLT) se propone como un tratamiento no invasivo, actuando como un fotomodulador celular, por lo que reduce el dolor, la inflamación, y estimula la regeneración tisular, previniendo daños. En el presente artículo se reporta a un niño de 11 años con una herida dolorosa de 4 meses en el borde posterior de la lengua que apareció tras una mordedura, en el que a la exploración clínica se encontró una lesión amarillenta con zonas enrojecidas, rodeada de un halo blanquecino de bordes redondeados. Para el tratamiento se utilizó LLLT, luego de una semana disminuyó el dolor, el paciente comenzó a comer correctamente, a los 15 días se observó una reducción de los bordes rojizos de la lesión, pasado el mes la lesión había remitido casi por completo. La LLLT se describe como un tratamiento eficaz, no invasivo, reduciendo los síntomas, y mejorando la calidad de vida del paciente al promover la curación de las lesiones.
