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MRI of the brain showing scattered T2 hyperintensities in the subcortical white matter including the left basal ganglia, periatrial region, and insula, and restricted diffusion within the left posterior basal ganglia (arrow)
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Ponatinib is a highly potent tyrosine kinase inhibitor shown to have excellent outcomes in the treatment of acute and chronic leukemias. Despite its high efficacy, ponatinib has been shown to carry an increased risk for cardiovascular adverse events, not attributable to a known mechanism. We present a case of a patient with Philadelphia chromosome-...
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... Panel CT stroke study revealed left M1 occlusion with distal reconstitution, and perfusion deficit in the left middle cerebral artery (MCA) territory. MRI of the brain showed scattered T2 hyperintensities in the subcortical white matter including the left basal ganglia, periatrial region, and insula, and restricted diffusion within the left posterior basal ganglia (Figure 1). An electrocardiogram revealed that sinus rhythm and troponin levels were normal. ...
