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The present research was focused to develop the formulation to release the drug (Moxifloxacin hydrochloride) for an extended period of time and buoyant, thus prolong the residence time of formulation in the stomach. Sodium alginate and pectin are used as polymers. Tri sodium citrate and calcium carbonate are the main ingredients for the formation o...
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Context 1
... the present research formulation of floating in situ gels, these reside specifically in stomach. Moxifloxacin HCl (Fig:1) is a Group 4 fluoro quinolone with activity against a broad spectrum of gram positive, gram negative and anaerobic bacterial pathogens. It acts by inhibiting the Topoisomerase II (DNA gyrase) and Topoisomerase IV. ...
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Citations
... Sivannarayana et.al. [17] and Gupta et. al [18] , the criteria for four time points are defined as in Table 6: provide information on the effects that may occur in the conjunctiva following exposure to a test substance. ...
Aim: Atazanavir sulphate belongs to BCS class II drug, its oral bioavailability is limited due to its rapid first-pass metabolism and P-gp efflux. Materials & methods: The in situ floating gel using the complexed drug was prepared by ion gelation method and optimized the formulation as per 3 ² full factorial design. Results: Floating lag time of optimized formulation was found to be 18 s and percentage drug release of 94.18 ± 0.18 % at the end of 16 h. The concentration of gelling polymer affects drug release and a floating lag time and vice versa. Conclusion: In situ floating gel of atazanavir sulphate was found promising to sustain drug release due to an increased gastric residence time, which leads to enhanced potential therapy.
