FIGURE 1 - uploaded by Charalampos Harris Spiridonidis
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Lytic lesion of the T12 vertebra in an athletic 51-year-old man with severe back pain and a compression fracture of T11. The CT scan shows a paraspinal mass extending from T10 to L1, with involvement of the adjacent vertebrae and diffuse large B cell lymphoma on biopsy. A bone mineral density scan of the lumbosacral spine revealed osteopenia.
Source publication
Lymphoid malignancies can damage bone by invasion, marrow expansion, and humoral factors causing demineralization, but the frequency of these events is not well known. Fifty patients with lymphoid malignancies (particularly non-Hodgkin's lymphoma and chronic lymphocytic leukemia) and a good performance status treated at a single hematology practice...
Context in source publication
Context 1
... mechanisms for this process include cytokine-mediated mechanisms such as osteoclast activating factor, interleukin-6 and RANK-L (re- ceptor activator for nuclear factor kappa B ligand). Individual case reports of patients with lytic lesions and hypercalcemia peppered the medical litera- ture, 1-5 such as the one depicted in Figure 1. Two case series have also been reported. ...
