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Low-power, 100-kHz clock oscillator schematic, including nA current reference generator and startup circuit. Total dynamic current draw is 630 nA. 

Low-power, 100-kHz clock oscillator schematic, including nA current reference generator and startup circuit. Total dynamic current draw is 630 nA. 

Source publication
Conference Paper
Full-text available
A custom IC for wireless bladder pressure sensing incorporates power-management circuitry to limit the active time of the instrumentation circuitry and to minimize telemetry rate. Instrumentation circuits are operated with low duty factors in a pipelined manner to generate 100-Hz pressure samples. Telemetry rate is adapted according to sample activ...

Contexts in source publication

Context 1
... Details of the wireless battery recharger were published in [3] and are beyond the scope of this manuscript. The PMU proposed here is a collection of circuits respon- sible for controlling the overall current draw of the ASIC, as detailed in Fig. 1b. The PMU circuits are always running and set the baseline current draw of the system. The power consumption of these circuits was reduced as much as possible while maintaining acceptable performance and matching. The power consumption of other analog circuits is reduced by a digital finite state machine which turns the instrumentation circuitry on/off in a pipelined manner to minimize the active time for each stage. Because the wireless sensor is powered by a secondary cell with fairly large internal resistance, the battery voltage changes significantly with load current, in addition to the slow decrease caused by depletion of stored charge. The PMU uses a simple linear voltage regulator to reduce instrumentation circuit and clock oscillator voltage coefficient requirements. The regulator schematic is presented in Fig. 2. The regulator topology deviates from the traditional low- drop-out configuration by generating its bandgap reference from the regulated supply, V , rather than the unregulated input voltage, V BAT . This configuration provides excellent voltage regulation because the bandgap supply sensitivity is reduced by the loop gain of the regulator, but proper startup and overall stability is more difficult to achieve. A voltage divider formed by matched, long composite transistors M F1-F6 provides a feedback factor of 1⁄2 to the error amplifier; the resulting output voltage of the regulator is twice V . This circuit has potentially two undesirable operating points, a zero-current mode and a second mode in which FETs M 1-7 are in triode, and Q 3 carries a very low current. The AC- coupled startup networks provide pulses of current that over- come these modes, provided that the input supply VBAT has a ramp-up rate greater than 100 V/s [5]. The clock source for the PMU state machine is a low- power, current-limited relaxation oscillator, shown in Fig. 3. The oscillator symmetrically charges capacitor C 0 at a fixed rate of I 0 through an H-bridge switch configuration. When the differential voltage across C 0 exceeds the comparator hystere- sis threshold V TH [6], the capacitor polarity is flipped. The circuit produces a triangle wave of amplitude ±V TH across C 0 and a corresponding binary clock waveform at the comparator outputs. The oscillation period is given by 2 ⁄ 4 , where is the total loop delay from the oscillator output through C 0 . An oscillation frequency of 100 kHz was designed with C 0 = 3.4 pF, V TH = 55 mV, I 0 = 60 nA and T D of 940 ns. The charging current I is copied from the nA bias generator of Fig. 3 [7], which was designed using inversion-coefficient methodology [8] to ensure reasonable current matching. Matched devices M 1-2 , M 7-9 , and M 8-10 were biased in mod- erate inversion with inversion coefficients of 0.3. Transistors M 3 and M 4 were biased deep into weak inversion with IC = 0.03 to create a 30-nA reference current with R 1 = 230 k Ω . The common-mode level of C 0 is determined by the ratio of small-signal output resistances of M 9 and M 10 . Since NMOS devices have lower and increased junction leakage, the comparator uses a PMOS input pair and can tolerate input common-mode levels including 0V. Static differential-mode offsets caused by non-equal charge injection and comparator differential pair offset can change the clock duty cycle from the nominal 50%. Dynamic differential-mode offsets such as the comparator input-referred thermal and 1/ noise and the uncorrelated channel noise between M 9 and M 10 plus dynamic changes in T are the primary sources of oscillator jitter. The PMU state machine controls power consumption through low-duty-cycle operation of analog circuits. This is possible because of the huge speed difference between instrumentation circuitry and the required 100-Hz sampling rate for bladder pressure. The proposed PMU state machine applies power activation to individual circuits, creating a sample pipe- line in which sensed information is passed between sequential stages as charge stored on switched capacitors. Stages are switched off as sampled are acquired and conveyed to the fol- lowing stage. The PMU state machine timing diagram illu- strated in Fig. 4 shows power gating signals of Fig. 1a. Fast-settling elements, such as the piezoresistive pressure transducer and IDAC, have lower duty factors than switched- capacitor and bias circuits, which have longer warmup, step response, and settling limitations. To reduce peak current and RF interference, the FSK transmitter is separately activated for 450 μs after each sample period as determined by the adaptive-rate transmitter described in Section III. The sample rate of the pressure sensing system is 100 Hz, and the PMU state machine requires just 475 μs to acquire a sample, although some instrumentation circuits are only activated for a small fraction of this time. The time-average current consumption of individual instrumentation circuits is thus reduced to between 1.4 and 6.5 percent. The average current for the pressure sensor IC is dominated by the transmitter when the transmission rate is greater than 25 Hz, as shown in Fig. 5. The PMU, piezoresistive pressure transducer, and digital circuits dominate power consumption at lower rates. III. A CTIVITY D ETECTOR FOR A DAPTIVE T RANSMISSION R ATE C ONTROL A sample rate of 100 Hz is required to capture fast transients in bladder pressure, but a fixed, 100-Hz telemetry would account for 81% of the system current. Because bladder contractions are intermittent, significant power savings can be achieved by only transmitting “active” samples. A digital im- plementation of an activity detector designed specifically for bladder pressure signals is presented in Fig. 6a. The activity detector is based on the first and second differences of the signal [9]. When these differences are combined, the expression becomes that of a 2 nd -order FIR filter given by 1 2 . (1) Coefficients α and β can be selected such that is an in- dicator of activity. Coefficient values of -1⁄2 were chosen to create a high-pass filter with a peaking response at ⁄ 4 , unity gain at ⁄ 2 and zero DC gain. The FIR filter output is com- pared to a threshold by a magnitude comparator; if the sample is significant enough, it is transmitted. A rate control register, which sets the baseline transmission rate from 1.5 – 100 Hz, is adjusted based on the level of pressure activity. Samples are transmitted at the baseline rate even if the comparator does not indicate activity. The rate control register is incremented when the magnitude comparator de- tects activity, and is decremented at a constant rate of 40 ms. Thus, transmission rate remains high for a period of time after activity. Waveforms demonstrating this operation are shown in Fig. 6b for representative, non-voiding bladder contractions. IV. E XPERIMENTAL R ESULTS The PMU circuits ...
Context 2
... Details of the wireless battery recharger were published in [3] and are beyond the scope of this manuscript. The PMU proposed here is a collection of circuits respon- sible for controlling the overall current draw of the ASIC, as detailed in Fig. 1b. The PMU circuits are always running and set the baseline current draw of the system. The power consumption of these circuits was reduced as much as possible while maintaining acceptable performance and matching. The power consumption of other analog circuits is reduced by a digital finite state machine which turns the instrumentation circuitry on/off in a pipelined manner to minimize the active time for each stage. Because the wireless sensor is powered by a secondary cell with fairly large internal resistance, the battery voltage changes significantly with load current, in addition to the slow decrease caused by depletion of stored charge. The PMU uses a simple linear voltage regulator to reduce instrumentation circuit and clock oscillator voltage coefficient requirements. The regulator schematic is presented in Fig. 2. The regulator topology deviates from the traditional low- drop-out configuration by generating its bandgap reference from the regulated supply, V , rather than the unregulated input voltage, V BAT . This configuration provides excellent voltage regulation because the bandgap supply sensitivity is reduced by the loop gain of the regulator, but proper startup and overall stability is more difficult to achieve. A voltage divider formed by matched, long composite transistors M F1-F6 provides a feedback factor of 1⁄2 to the error amplifier; the resulting output voltage of the regulator is twice V . This circuit has potentially two undesirable operating points, a zero-current mode and a second mode in which FETs M 1-7 are in triode, and Q 3 carries a very low current. The AC- coupled startup networks provide pulses of current that over- come these modes, provided that the input supply VBAT has a ramp-up rate greater than 100 V/s [5]. The clock source for the PMU state machine is a low- power, current-limited relaxation oscillator, shown in Fig. 3. The oscillator symmetrically charges capacitor C 0 at a fixed rate of I 0 through an H-bridge switch configuration. When the differential voltage across C 0 exceeds the comparator hystere- sis threshold V TH [6], the capacitor polarity is flipped. The circuit produces a triangle wave of amplitude ±V TH across C 0 and a corresponding binary clock waveform at the comparator outputs. The oscillation period is given by 2 ⁄ 4 , where is the total loop delay from the oscillator output through C 0 . An oscillation frequency of 100 kHz was designed with C 0 = 3.4 pF, V TH = 55 mV, I 0 = 60 nA and T D of 940 ns. The charging current I is copied from the nA bias generator of Fig. 3 [7], which was designed using inversion-coefficient methodology [8] to ensure reasonable current matching. Matched devices M 1-2 , M 7-9 , and M 8-10 were biased in mod- erate inversion with inversion coefficients of 0.3. Transistors M 3 and M 4 were biased deep into weak inversion with IC = 0.03 to create a 30-nA reference current with R 1 = 230 k Ω . The common-mode level of C 0 is determined by the ratio of small-signal output resistances of M 9 and M 10 . Since NMOS devices have lower and increased junction leakage, the comparator uses a PMOS input pair and can tolerate input common-mode levels including 0V. Static differential-mode offsets caused by non-equal charge injection and comparator differential pair offset can change the clock duty cycle from the nominal 50%. Dynamic differential-mode offsets such as the comparator input-referred thermal and 1/ noise and the uncorrelated channel noise between M 9 and M 10 plus dynamic changes in T are the primary sources of oscillator jitter. The PMU state machine controls power consumption through low-duty-cycle operation of analog circuits. This is possible because of the huge speed difference between instrumentation circuitry and the required 100-Hz sampling rate for bladder pressure. The proposed PMU state machine applies power activation to individual circuits, creating a sample pipe- line in which sensed information is passed between sequential stages as charge stored on switched capacitors. Stages are switched off as sampled are acquired and conveyed to the fol- lowing stage. The PMU state machine timing diagram illu- strated in Fig. 4 shows power gating signals of Fig. 1a. Fast-settling elements, such as the piezoresistive pressure transducer and IDAC, have lower duty factors than switched- capacitor and bias circuits, which have longer warmup, step response, and settling limitations. To reduce peak current and RF interference, the FSK transmitter is separately activated for 450 μs after each sample period as determined by the adaptive-rate transmitter described in Section III. The sample rate of the pressure sensing system is 100 Hz, and the PMU state machine requires just 475 μs to acquire a sample, although some instrumentation circuits are only activated for a small fraction of this time. The time-average current consumption of individual instrumentation circuits is thus reduced to between 1.4 and 6.5 percent. The average current for the pressure sensor IC is dominated by the transmitter when the transmission rate is greater than 25 Hz, as shown in Fig. 5. The PMU, piezoresistive pressure transducer, and digital circuits dominate power consumption at lower rates. III. A CTIVITY D ETECTOR FOR A DAPTIVE T RANSMISSION R ATE C ONTROL A sample rate of 100 Hz is required to capture fast transients in bladder pressure, but a fixed, 100-Hz telemetry would account for 81% of the system current. Because bladder contractions are intermittent, significant power savings can be achieved by only transmitting “active” samples. A digital im- plementation of an activity detector designed specifically for bladder pressure signals is presented in Fig. 6a. The activity detector is based on the first and second differences of the signal [9]. When these differences are combined, the expression becomes that of a 2 nd -order FIR filter given by 1 2 . (1) Coefficients α and β can be selected such that is an in- dicator of activity. Coefficient values of -1⁄2 were chosen to create a high-pass filter with a peaking response at ⁄ 4 , unity gain at ⁄ 2 and zero DC gain. The FIR filter output is com- pared to a threshold by a magnitude comparator; if the sample is significant enough, it is transmitted. A rate control register, which sets the baseline transmission rate from 1.5 – 100 Hz, is adjusted based on the level of pressure activity. Samples are transmitted at the baseline rate even if the comparator does not indicate activity. The rate control register is incremented when the magnitude comparator de- tects activity, and is decremented at a constant rate of 40 ms. Thus, transmission rate remains high for a period of time after activity. Waveforms demonstrating this operation are shown in Fig. 6b for representative, non-voiding bladder contractions. IV. E XPERIMENTAL R ESULTS The PMU circuits were integrated with instrumentation circuits to produce a pressure sensor IC for wireless bladder pressure monitoring. The 6.25 mm 2 IC was fabricated in a 0.5- μm CMOS process and a die photo is presented in Fig. 7. The current consumption of the pressure sensor IC was measured to verify proper PMU function and to determine leakage currents not modeled through simulation. The IC draws a very low current with intermittent bursts of high peak current, when samples are acquired and transmitted. Dynamic current draw was measured by amplifying the voltage drop across a 10- Ω shunt resistor. An oscilloscope trace of the dynamic current draw is shown in Fig. 8. The minimum ...

Citations

... The offset removal system was combined as part of a wireless bladder pressure sensing ASIC fabricated in OnSemi C5F 0.5-μm (Fig. 6) [9]. The IDAC and digital components of the cancellation system consumed 0.3 mm 2 . ...
Conference Paper
Full-text available
Implanted pressure sensors suffer from long-term offset drift due to atmospheric changes, package moisture absorption, and patient factors such as posture, implant shift, and tissue overgrowth. Traditionally, wide dynamic range instrumentation is used to satisfy the full-scale and sensitivity requirements for a given application. Transmission of extra bits greatly increases the power draw of an implanted medical device, and simple AC-coupling cannot monitor static pressures. We present a mixed-signal offset cancellation loop to maximize the AC dynamic range of instrumentation circuitry. A digital implementation allows for designer control of the cancellation system time constant and was specifically designed for power-gated pressure sensors. Pressure offset is calculated by digital integration and a bipolar IDAC with coarse/fine tuning injects an offset-cancelling current into a standard piezoresistive MEMS pressure sensor. Test results showed a dynamic range increase of 2.9 bits using dynamic offset cancellation, for an effective sensing range of 11 bits using 8-bit instrumentation. The measured step response of the system showed an overall highpass response of 2.3–3.8 mHz. This approach is therefore relevant for bio-sensing of pressures in organs with a very slow physiologic response, e.g. the bladder.
... We adopted a highly-integrated approach to the pressure monitor, which consists of a custom integrated circuit, MEMS absolute pressure sensor [6], rechargeable battery, and discrete inductive antennas for wireless charging and data telemetry (Fig. 2). To reduce the implant battery size, the pressure monitor ASIC was designed with three charge-maintaining strategies: ultra-low-power instrumentation and adaptive rate telemetry [7], long-range RF wireless charging, and a sub-nA standby mode that may be remotely activated [8]. ...
... Low power CMOS instrumentation circuits have speeds that far exceed this low sample rate. Significant power may be saved by strategically turning off circuit components between sample periods [7]. Here, we demonstrate a power management strategy that sequentially switches the bias point of circuits. ...
Conference Paper
Full-text available
Conditional neuromodulation in which neurostimulation is applied or modified based on feedback is a viable approach for enhanced bladder functional stimulation. Current methods for measuring bladder pressure rely exclusively on external catheters placed in the bladder lumen. This approach has limited utility in ambulatory use as required for chronic neuromodulation therapy. We have developed a wireless bladder pressure monitor to provide real-time, catheter-free measurements of bladder pressure to support conditional neuromodulation. The device is sized for submucosal cystoscopic implantation into the bladder. The implantable microsystem consists of an ultra-low-power application specific integrated circuit (ASIC), micro-electro-mechanical (MEMS) pressure sensor, RF antennas, and a miniature rechargeable battery. A strategic approach to power management miniaturizes the implant by reducing the battery capacity requirement. Here we describe two approaches to reduce the average microsystem current draw: switched-bias power control and adaptive rate transmission. Measurements on human cystometric tracings show that adaptive transmission rate can save an average of 96% power compared to full-rate transmission, while adding 1.6% RMS error. We have chronically implanted the wireless pressure monitor for up to 4 weeks in large animals. To the best of our knowledge these findings represent the first examples of catheter-free, realtime bladder pressure sensing from a pressure monitor chronically implanted within the bladder detrusor.
Chapter
Control of urine leakage is of major importance to spinal cord injured (SCI) patients and the elderly, with untreated urinary incontinence leading to contact dermatitis and pressure ulcers due to prolonged exposure to excess moisture. In one study, 81% of all patients with pressure ulcers had urinary incontinence. In addition, pressure ­ulcers exposed to urine are more susceptible to infection since the urine alters the pH ­balance of the skin and reduces resistance to bacterial invasion. Both SCI patients and the elderly are highly susceptible to incontinence, which is classically divided into two major types: overactive bladder and stress urinary incontinence, both of which can lead to uncontrolled urine leakage.
Conference Paper
Implantable medical devices intended for chronic application in deep bodily organs must balance small size with battery capacity. Wireless battery recharge of implanted sensors is a viable option to reduce implant size while removing the physical and regulatory hindrance of continuous RF powering. This paper presents wireless battery recharge circuitry developed for an implantable pressure sensor. The circuits include an RF/DC rectifier, voltage limiter, and constant-current battery charger with 150-mV end-of-charge hysteresis. An AM demodulator drawing zero DC current allows for transmission of commands on the recharge carrier. Reception of a time- and value-coded shutdown command places the implantable system into a 15 nanoampere standby mode. The system can be wirelessly activated from standby by reactivating the external wireless recharge carrier. Test results of the wireless system showed a standby current of 15-nA such that the implant standby time is limited by battery self-discharge. Wireless recharge tests confirmed that a constant recharge rate of 200 μA could be sustained at implant depths up to 20 cm, but with low power transfer efficiency <; 0.1% due to small implant coil size. Battery charge measurements confirmed that daily 4-hour recharge periods maintained the implant state of charge and this recharging could occur during periods of natural patient rest.