Localization of substantia nigra in the cross section of a human midbrain. a-a macropreparation fixed with formalin; b-staining by Nissl method; c-immunohistochemical identification of tyrosine hydroxylase; SN-substantia nigra; 1-ventral area with sparsely packed neurons; 2-dorsal area with densely packed neurons; dotted line-the boundaries of substantia nigra pars compacta 

Localization of substantia nigra in the cross section of a human midbrain. a-a macropreparation fixed with formalin; b-staining by Nissl method; c-immunohistochemical identification of tyrosine hydroxylase; SN-substantia nigra; 1-ventral area with sparsely packed neurons; 2-dorsal area with densely packed neurons; dotted line-the boundaries of substantia nigra pars compacta 

Source publication
Article
Full-text available
Background. Up to the moment there is no universally accepted scheme of spatial organization of the groups of neurons of substantia nigra pars compacta of the human midbrain. A detailed study of the architectonics of this structure is necessary for pathomorphological analysis of agerelated changes in the nervous tissue and the associated neurodegen...

Similar publications

Article
Full-text available
To understand the connectome of the axonal arborizations of dopaminergic midbrain neurons, we investigated the anterograde spread of highly sensitive viral tracers injected into the ventral tegmental area (VTA) and adjacent areas in 3 macaques. In 2 monkeys, injections were centered on the lateral VTA with some spread into the substantia nigra, whi...
Article
Full-text available
The possibilities of neural transplantation were studied in functional motor recovery of 21-23-month-old Sprague-Dawley male rats. Age-dependent functional losses of rats were evaluated using the Marshall scale for swimming abilities, narrow bridge task and suspension on horizontal wire. Fifteen rats exhibited motor disabilities when were compared...
Article
Full-text available
3,4-Methylenedioxymethamphetamine (MDMA, “ecstasy”) is an amphetamine-related drug that may damage the dopaminergic nigrostriatal system. To investigate the mechanisms that sustain this toxic effect and ascertain their sex-dependence, we evaluated in the nigrostriatal system of MDMA-treated (4 × 20 mg/kg, 2 h apart) male and female mice the activit...
Article
Full-text available
Mitochondrial ferritin (FtMt) is a novel ferritin that is localized in the mitochondria. FtMt expression is low in the liver and spleen, and high in the heart, testis, and brain. We previously detected FtMt in dopaminergic neurons in the substantia nigra pars compacta (SNc) in human and monkey midbrains. We investigated the localization and express...
Article
Full-text available
Brain tissue contains autofluorescing elements that potentially impede accurate identification of neurons when visualized with fluorescent microscopy. Age-related accumulation of molecules with autofluorescent properties, such as lipofuscin, can possess spectral profiles that invade the typical emission range of fluorophores commonly utilized in fl...