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Lippia chevalieri Moldenke (Photo catch in the forest of Gonsè, 25 km of Ouagadougou by Bangou M. Jean; 15h35mn/04 July 2011)
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Lippia chevalieri Moldenke is an herbaceous, belonging to the Verbenaceae family largely used in folk medicine in Burkina Faso and in certain African countries. The aim of the present review was to give a detailed literature survey on its traditional uses, and phytochemistry and therapeutical properties in order to systematize achievements and dire...
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Lippia schaueriana Mart. (Verbenaceae) is an endemic species of Caatinga with a restricted distribution to the states of Bahia and Pernambuco, which presents itself as a potential source of raw material for extraction of essential oil and exploitation by the chemical and pharmaceutical industries. Considering that there are no reports in the litera...
This study evaluated the influence of light quality on growth and essential oil production in three chemotypes of Lippia alba (BGEN-01, BGEN-02, and BGEN-42) grown in vitro. These chemotypes differed both in ploidy and in the predominant essential oil produced. The treatments were fluorescent lamps, white light-emitting diode (LED) bulbs, and blue/...
Lippia alba (Verbenaceae Family) is an aromatic shrub native to Latin America, with recognized medicinal properties and a well-known high phenotypical plasticity in response to environmental factors. In order to identify the parameters that potentiate its in vitro anti-proliferative effect on human leukemia cells (K562), a matrix was designed for t...
Citations
... Among the flavonoids identified, naringenin and cirsimaritin were found in the three extracts studied, which were reported in the species L. salviifolia Cham., L. velutina Schauer, L. balansae Briq., L. lupulina Cham., L. graveolens Kunth, L. citriodora (Palau) Kunth, L. javanica (Burm.f.) Spreng., L. chevalieri Moldenke, and L. lacunosa Mart. & Schauer [9,45,46,48,50,51]. Thus, we suggest that these flavonoids can be considered as chemical markers for the genus. ...
... Plants 2023, 12, x FOR PEER REVIEW Among the flavonoids identified, naringenin and cirsimaritin were found in t extracts studied, which were reported in the species L. salviifolia Cham., L. Schauer, L. balansae Briq., L. lupulina Cham., L. graveolens Kunth, L. citriodora Kunth, L. javanica (Burm.f.) Spreng., L. chevalieri Moldenke, and L. lacunosa M Schauer [9,45,46,48,50,51]. Thus, we suggest that these flavonoids can be consid chemical markers for the genus. ...
Species belonging to the genus Lippia are used worldwide as foods, beverages, and seasonings. Studies have demonstrated that these species have antioxidant, sedative, analgesic, anti-inflammatory, and antipyretic activities. This work aimed to evaluate the antibacterial activity and anxiolytic effect by different pathways of essential oils and ethanolic extracts of three species of Lippia (Lippia alba, Lippia sidoides, and Lippia gracilis). The ethanolic extracts were characterized by HPLC-DAD-ESI-MSn and their phenolics were quantified. The antibacterial activity was evaluated by determining the minimal inhibitory concentration and modulation of antibiotic activity, and toxic and anxiolytic effects were evaluated in the zebrafish model. The extracts showed compositions with a low ratio and shared compounds. L. alba and L. gracilis showed higher amounts of phenols and flavonoids, respectively. All extracts and essential oils presented antibacterial activity, especially those obtained from L. sidoides. On the other hand, L. alba extract presented the most significant antibiotic-enhancing effect. The samples were not toxic after 96 h of exposure, but showed an anxiolytic effect through modulation of the GABAA receptor, while L. alba extract acted via modulation of the 5-HT receptor. This new pharmacological evidence opens horizons for therapeutic approaches targeting anxiolytic and antibacterial therapies and food conservation using these species and their constituents.
... Parmi les groupes chimiques révélés, les tanins, les saponosides et les stérols avaient été signalés par Konaté (Konaté, 2005), les flavonoïdes avait été signalés par Bangou (Bangou et al., 2012). ...
Au Mali, le Malarial 5 qui est un Médicament Traditionnel Amélioré (MTA) produit en partie à base de feuilles de Lippia chevalieri est utilisé pour traiter les symptômes du paludisme simple. Les feuilles de Lippia chevalieri cultivé peuvent être utilisées pour la préparation des MTA lorsqu’elles sont de qualité. La présente étude portée sur le contrôle physicochimique a montré que les feuilles de Lippia chevalieri cultivé ont des teneurs en eau inférieures à 10%, celles des cendres totales un peu élevées et celles des cendres insolubles dans l’acide chlorhydriques à 10% faibles. Les meilleurs rendements des extractions sont obtenus par l’eau par infusion et par décoction. Plusieurs groupes chimiques comprenant entre autres des caroténoïdes, des coumarines, des mucilages, des flavonoïdes ont été révélés. In Mali, Malarial 5, which is an Improved Traditional Medicine (ITM) produced partly from the leaves of Lippia chevalieri, is used to treat the symptoms of uncomplicated malaria. The leaves of cultivated Lippia chevalieri can be used for the preparation of improved traditional medicines because they are of good quality. This paper focuses on the physicochemical control which showsthat the leaves of cultivated Lippia chevalieri contain less than 10% of moisture content. The total ash content was a little higher, and the acid insoluble ash was low. The best yields of extractions are obtained with water through infusion and decoction. Several chemical compounds including carotenoids, coumarins, mucilage, and flavonoids were revealed.
... The dominant components in oil from the leaves are β-caryophyllene, elemol, thymol and caryophyllene (Mevy et al., 2007). Other major components of leaves are numerous polyphenolic compounds which are flavones and flavanols (Bassole et al., 2003;Bangou et al., 2012b). The analgesic, antipyretic and antiplasmodial activities of L chevalieri have been demonstrated to be attributable to the various components of its essential oil (Abena et al., 2003;Kunle and Egharevba, 2012). ...
Malaria is a leading cause of morbidity and mortality in many developing tropical countries, particularly in children and pregnant women. With growing concerns about the development of resistance to current antimalarial drugs, herbal alternatives may provide significant and sustainable treatment options in affected regions. This review aimed at providing an updated overview of available data on Herbal Medicinal Products (HMPs) with reproducible evidence-based antimalarial efficacies. In addition, it identified the antiplasmodial phyto-constituents and discussed the potential of these products to
modulate activities of drug metabolizing enzymes and drug transport systems. This is particularly important because the co-morbidity of malaria with other diseases, often prevalent in malaria endemic regions, is marked by a concurrent use of herbal antimalarial products with conventional drugs. An extensive literature search was undertaken and the information obtained were critically analysed. Enormous work has been reported on investigations of the antiplasmodial activity of herbs, and more than 1000 plants have been studied using in vitro and animal malaria infection models. However, only a
few of these HMPs have been subjected to randomized clinical trials. Herb-drug interactions are of great concern since phytochemical compounds in HMPs are subject to the same pharmacokinetic processes that determine the fate of synthetic drugs in the human body. Thus, specific effects of these clinically effective antimalarial HMPs on drug metabolizing enzymes were reported with a view to documenting information for optimization of their therapeutic utility. Beneficial and adverse clinically significant
interactions were also identified for close therapeutic attention.
Key words: Antimalarial herbal products, evidence-based efficacy, cytochrome P450, herb-drug interactions
... Phytochemistry and biological screening of these plants form integral part is our research plan. Several studies were undertaken on these plants: polyphenolic compound contents and chromatographic profiles of phenols acids and flavonoids [1], [4], [7], enzymatic activity [4], [8], antioxidant and antibacterial activities [1], [7], [9], [10].The most elucidated studies on these plants were directed towards their essential oils contents [8], [11], [12], [13]. According to Nwachukwu and Uzoeto [14] acetone, ethanol, methanol, hot and cold water extracts of leaves of Vitex doniana have antimicrobial properties which can be pharmaceutically exploited on Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Bacillus subtilis and Staphylococcus aureus. ...
p> Lantana rhodesiensis Moldenke, Lippia chevalieri Moldenke, Vitex diversifolia Bak and Vitex doniana Sweet are four species of Verbenaceae family widely used in traditional medicines in Burkina. The aim of this investigation was to study the chromatographic profile of phenols acids and that of the flavonoids as well as the antioxidants activities. Then, three types of extraction were made: acetonic (100%), decoction, ethanol-water(80/20 + 20/80); and fractions of ethanol-water which arehexane fraction (HF), ethyl acetate fraction (EAF), butanol fraction (BF) and aqueous fraction (AqF) of each species. These evaluations were supplemented by the quantification of the metal ions and the characterization by atomic absorption and HPLC-DAD methods of totals phenols acids and totals flavonoids.The whole of these proportioning was directed against the antioxidant activity through the anti-DPPH* (free radical scavenging activity), anti-TAC (total antioxidant capacity) and anti-IRP(iron reducing power).36 flavonoids on 41 were highlighted by the HPLC-DAD method. A derivative glycosylate of quercetin was detected in the V. diversifolia extracts. L. chevalieri presented the strongest value in terms of ions content with a 55.88 g/kg of calcium.In terms of antioxidant activity, L. rhodesiensis and L. chevalieri presented the best activities on total antioxidant activity and anti-DPPH, and iron reducing power respectively.It’s arise that decoction extract have the best’s activities and can justify the traditional uses.</p
... Lippia multiflora is an aromatic plant, a shrub of the Verbenaceae family (Mindiédiba et al., 2013) of which inflorescences, leaves and roots are used for food or medicine in Benin where it is traditionally known as endowed with a lot of medicinal virtues (Adjanohoun and de Souza, 2002;Akoègninou et al., 2006). Across Africa, the plant is traditionally used to treat bronchial affections, malaria, conjunctivitis, gastric unrests, enteritis, cough and the rum (Pascual et al., 2001). ...
... The genus Lippia belongs to the Verbenaceae family and comprises approximately 200 species of herbs, shrubs and small trees (Sanders, 2001). Several species of the genus Lippia are used for treatment of respiratory disorders, being employed as remedy for colds, grippe, bronchitis, coughs and asthma (Caceres et al., 1991;Forestieri et al., 1996;Pascual et al., 2001;Jean et al., 2012). They are also commonly utilized as gastrointestinal remedies and as seasoning for food preparation (Hennebelle et al., 2008;Oliveira et al., 2007, Pascual et al., 2001. ...
Several Lippia species have been used in folk medicine mainly for gastrointestinal and respiratory diseases. Their biological properties have been partially associated to the terpenoids found in their essential oils. According to the World Health Organization, cancer is the leading cause of death worldwide and is described as a complex group of diseases with several hallmarks. One of its acceptable defining features is the cell proliferation beyond their boundaries forming the tumors. Importantly, some drugs currently available were discovered by the investigation of plant secondary metabolites. Thus, this study aimed to evaluate in vitro cytotoxic effect of the essential oils extracted from five Lippia species against tumor cell lines. The results indicated that mouse colon carcinoma CT26.WT cell line viability was significantly reduced showing an IC50 of 19.05, 30.20 and 36.30 μg/ml when treated with the essential oils of L. sidoides, L. salviifolia and L. rotundifolia, respectively. Human lung carcinoma A549 cell line also had a compromised viability to the action of L. alba carvone chemotype essential oil. The tested essential oils did not compromise viability of the normal cell line CHO. These finds suggest that the studied Lippia essential oils might be good candidates for further in-depth studies.
