Fig 1 - available via license: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Content may be subject to copyright.
Left breast fungating ulcerating mass 12 × 7 include nipple areolar complex not attached to chest wall, no axillary lymphadenopathy.
Source publication
Introduction
Breast cancer is the most common diagnosed cancer among women worldwide. Invasive ductal carcinoma (IDC) is the most common type, on the other hand, squamous cell carcinoma of the skin (SCC) overlying the breast is a rare tumor. The co-presence of two tumor types in one organ is even a rarer entity, termed as collision tumor. Only 3 kn...
Context in source publication
Similar publications
Objective:
We aimed to investigate the distinction between Paget's disease of the breast (PDB) and malignant tumor invasion of nipple-areolar complex (MTION) with Magnetic resonance imaging (MRI) findings without the need for skin punch biopsy.
Materials and methods:
MRI findings of 16 patients with pathologically proven PDB and 11 patients with...
Citations
... Squamous cell carcinoma of the breast has been described in combination with invasive ductal carcinoma as a collision tumour but more rarely it has been seen in combination with invasive lobular carcinoma of the same breast [9]. There are a few case reports of squamous cell carcinoma of the breast skin with invasive ductal carcinoma occurring as a collision tumour [10]. ...
Introduction & importance
Invasive ductal carcinoma is the commonest primary breast carcinoma to metastasize to the axillary nodes. Squamous carcinoma (SCC) of the breast is seen rarely as a primary breast malignancy. Breast SCC with coexistent invasive ductal/lobular carcinoma as a ‘collision tumour’ is rare.
Case presentation
A 52-year-old Sri Lankan female presented with a right sided breast lump and ipsilateral cystic axillary mass. She was diagnosed with locally advanced invasive breast carcinoma and underwent neoadjuvant chemotherapy followed by mastectomy and axillary clearance where tumour infiltration of the brachial plexus was observed. Histology revealed two separate carcinomas; an invasive carcinoma of the breast and squamous carcinoma in the axilla. A squamous primary was not found despite evaluation. The patient developed recurrent axillary ulceration due to residual tumour and was transferred for oncological care.
Clinical discussion
This patient had a biopsy-proven invasive breast carcinoma with a cystic axillary mass with lymphadenopathy. This was concluded as locally advanced breast cancer. Pathological examination of the specimen indicated the presence of two separate malignancies of the breast and axilla. No evidence of squamous metaplasia or carcinoma of the breast was seen on histology, neither was a squamous primary identified on imaging or endoscopy. Neoadjuvant therapy may have caused resolution of the squamous component.
Conclusion
The presence of two separate cancers of varied histology in the breast and ipsilateral axilla in close proximity to each other is a rare phenomenon. Clinicians must be cautious not to misinterpret it as evidence of lymphatic spread.
... In human medicine, some anatomical sites seem to be more involved than others, such as the mammary gland (Alawami et al., 2021), the genital tract (Tan et al., 2021), the urinary tract (Lamprou et al., 2021), the gastrointestinal tract (Yuan et al., 2021); the larynx and thyroid (Coca-Pelaz et al., 2016), the skin and appendages (Mancebo et al., 2015;Mizuta et al., 2021;Satter et al., 2009). Moreover, carcinomas and lymphohematopoietic system neoplasms or melanoma or sarcomas are frequently associated (Jafarian et al., 2015;Mancebo et al., 2015;Yuan et al., 2021). ...
Collision tumours are the coexistence, at the same site, of distinct tumours not macroscopically dis- tinguishable and consisting of two independent cell populations without histological admixture. In human medicine, collision tumours in different anatomical sites have been described. In the veterinary literature, few cases exist so far. A 12-year-old female Labrador with a mammary gland single nodular lesion was presented for clinical examination. The nodule was surgically removed and underwent histological and immunohistochemical analysis. Histopathological examination revealed two distinct malignant tumours: a mammary gland carcinoma and a cutaneous mast cells tumour. To the author’s knowledge, the paper reports the first case of a collision tumour composed of mammary gland neoplasia and mast cell tumour. The rising interest in collision tumours suggests widening their knowledge and setting up a multimodal approach that includes surgery and targeted therapy.
