Table 2 - uploaded by Julio Benites
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The composition of the essential oil from Pantana cámara L. (Verbenaceae) obtained by hydrodistillation of the aerial parts was examined by GC, GC/ MS, and 13C-NMR. The GC analysis showed that carvone is the most abundant monoterpene 75.9%, together with limonene 16.9%, accounting for 92.8% of the oil. The major components were also tested by "C-NM...
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... detector and injector were kept at 250°C and 240°C, respectively. Helium was used as carrier gas, at constant pressure 55 kPa for the OV-101 and the essential oil components is given in Table 2 and was made by comparison of their retention indices (RI) obtained from calculated values relative to C 8 -C 20 n-alkanes. The intensity of each peak was integrated. ...
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This study was aimed to provide the pharmacological basis for medicinal use of Lantana camara Linn. as an antispasmodic agent using in-vitro pharmacological assay. Lantana camara Linn. (Verbenaceae), is a widely growing shrub which found to be toxic to some animal species, has been used in the traditional medicine for treating many ailments. The pu...
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Citations
... This plant found and isolated various phytochemicals, including terpenoids, steroids, flavonoids, oligosaccharides, glycosides and naphthoquinones (Sousa and Costa, 2012). Many papers have been reported that this plant showed strong antioxidant capacity (Benites et al., 2009;Bhakta-Guha and Ganjewala, 2009); the antibacterial effects on B.subtilis, B.cereus, S.typhi, P.aeruginos, S.aureus (Barre et al., 1997;McGaw et al., 2005;Rasyid et al., 2020;Saleh et al., 1999); anti-inflammation (Wu et al., 2020) and cytotoxic effects on human cancers such as hepatocellular carcinoma, cervical cancer, oral cancer, lung cancer, brain cancer, prostate cancer (Badgujar et al., 2017;Bisi-Johnson et al., 2011;Meenakshi Sharma, 2020). With the increasing of cancer cases, the anti-cancer activity of plant extracts is a promising research orientation (Solowey et al., 2014). ...
Abstracts It has been demonstrated that Lantana camara possesses several therapeutic properties that can be used to treat various human diseases, including dermatological and gastrointestinal conditions, tetanus, malaria, and tumours. In this investigation, every collected part of L. camara was extracted with absolute methanol to examine its antioxidant capacity using the DPPH assay and its anti-leukemia activity on two AML cell lines, MOLM-13 and MV4-11. In addition, anti-inflammatory effectiveness was evaluated. The results show that extracts from various sections of L. camara have a significant ability to neutralize free radicals, as indicated by their EC50 values. Most of the extracts had values less than 100 μg/ml, with the flower extract having an even lower value of less than 50 μg/ml. Experiments on two AML cell lines showed that the anti-leukemia effects of the extracts were remarkable, with the most potent impact belonging to the root extract (IC50 was 9.78 ± 0.61 and 12.48 ± 1.69 for MOLM-13 and MV4-11 cell lines). The antitumor effect of the extracts was determined to be time- and dose-dependent and did not correlate with antioxidant capacity. Furthermore, when BJ cells were exposed to L. camara root and leaf extracts, their migratory potential was dramatically reduced compared to untreated cells. The extracts demonstrated potential anti-inflammatory capabilities by lowering NO production in LPS-induced BJ cells.
... spreading swelling from acute rheumatism in the joints and restricted gonorrhoea in the testes, the leaves are discutient and helpful. As a vermifuge, the dried fruit works.Fruit is emmenagogue, nervine, and cephalic; dried fruits have vermifuge properties; flowers are astringent and cold [14,15,16]. Among the Verbenaceae family of plants, the genus Lantana camara L. is significant for its medicinal, decorative, and essential oil production properties. ...
Essential oils constitute a major class of natural products. They possess various
biological activities like anti-inflammatory, anti-oxidant, analgesic, and antimicrobial
activities and have immense application in food, cosmetics and pharmaceutical
industries. In the current study, the essential oils were extracted from Vitex negundo
Linn, Lantana camara Linn using clavenger apparatus. The oil yield was calculated
based on the volume of the extracted oil per 200 g of the powdered leaves. The yield of
essential oil from 200 gm dried powder of V. negundo is 0.35 % whereas from 200 gm
dried powder of L. camara is 0.50 % at the extraction temperature of 100ºC and
extraction time of 7 hours.
... Additionally, it is also known as one of the best as well as easily obtainable materials for the isolation of EOs branded as Lantana oils [17]. These important EOs obtained from L.camara from different localities have been reported [15,18,19] and there important biological activites including antioxidant [20], antibacterial [21] as well as anti-inflammatory [22] have been reported . However, up to date almost 41 sequences including (rps3, atpB, ccsA, rpoC1, rpoC2, FT, GLO1,rpl32 and rbcL) have been deposited in the NCBI Genbank database [23] and recently the genome of L.camara is also reported [24] . ...
In the present era researchers are focusing on medicinal plant research throughout the world as medicinal plants are important and cheap source of drugs and have a long history. Most of the remedies in the traditional system were taken from plants due to lack of technology and using plants as medicines were proven to be useful. Lantana camara L. is an important medicinal and aromatic plant belonging to family Verbenaceae. The plant is a rich source of medicinal compounds and that is the reason it has been used for the treatment of various ailments i.e. malaria, cough, fever cold and cough etc. Several essential phytochemicals have been isolated from L.camara L. and the plant was reported to possess important compounds including triterpenoids, flavonoids, alkaloids, saponins, steroids and tannins. Moreover, it is also known as an essential oil producing plant and the essential oil is available in the market known as Lantana oils. Thus due to the above mentioned economic as well as medicinal properties of Lantana camara L. Here we report a comprehensive review on the ethnobotany, phytochemistry, pharmacology and toxicology of Lantana camara L. This review will serve as a baseline for researchers working in the field of genomics and molecular studies of medicinal plants.
... About 24-40 dead flowers were discovered inside. The plant's root system quickly recovers from repeated cuttings and produces new shoots [6]. ...
Scientists from all over the world are currently investigating medicinal plants. Plants have long been used as a source of medicine by humans due to their low cost and long history of use. Due to technological limitations, most traditional medicines in the past were derived from plants. Lantana camara belongs to the Verbenaceae family of plants. In this study, the antibacterial and phytochemical properties of Lantana camara extracts from Iraq were analyzed. The extract composition was analyzed using GC/MS. using the agar well diffusion method and broth dilution assay to evaluate the antimicrobial activity of each extract. The aerial parts of the Lantana camara herb were extracted with n-hexane, then ethanol, and finally methanol. The beneficial phytochemicals found in L. camara include triterpenoids, flavonoids, alkaloids, saponins, steroids, and tannins. This article will be useful for researchers studying the biological activity, phytochemical composition, and antibacterial activity of Lantana camara.
... The activity levels of S. undulata ranged from 0% for most of the extracts to 14.05% for the ethanolic leaf extract obtained by ultrasound extraction. Our anti-inflammatory results are in harmony with those found by [40], who found that the essential oil of Lantara Camara showed low anti-inflammatory activity (IC 50 = 81.5 µg/mL). The antidiabetic activity of Scorzonera undulata extracts was tested using two enzymatic assays: anti-alpha glucosidase and anti-alpha amylase activities, and acarbose (50 µg/mL) was tested as a reference. ...
The genus Scorzonera has various medicinal values. Species belonging to this genus were traditionally used as drugs or in food. The current study aimed to determine the phytochemical composition, antioxidant activity, and biological properties of the tuber, leaf, and flower of Scorzonera undulata extracts, collected from the southwest of Tunisia. Phenolic compounds from the three parts were extracted using two solvents (water and ethanol) and two extraction techniques (maceration and ultrasound). The total phenolic content was measured by the Folin–Ciocalteu assay. Furthermore, the chemical composition of Scorzonera undulata extract was also investigated by the LC-ESI–MS method using phenolic acid and flavonoid standards. The variation of the extraction methods induced a variation in the real potentialities of the three parts in terms of bioactive molecules. However, the aerial part of S. undulata (leaves and flowers) showed, in general, the highest phenolic contents. Twenty-five volatile compounds have been detected by GC-MS in S. undulata extracts; among them, fourteen were identified before derivatization. The DPPH test showed that the aerial part of the plant has a higher antioxidant activity compared to the tuber (25.06% at 50 µg/mL for the leaf ethanolic extract obtained by ultrasound extraction). For most biological activities (anti-Xanthine, anti-inflammatory, and antidiabetic (alpha-amylase and alpha-glucosidase)), the aerial parts (flowers and leaves) of the plant showed the highest inhibition than tubers.
... Schematic representation for the best three compounds(11,12, and 22) of the score normalization of the binding energy based on the number of non-hydrogen atoms of VPEO bound to CYP2C9 and xanthine oxidase. The surrounding amino acid residues in the binding pocket of CYP2C9 and xanthine oxidase within 3 Å are shown.Regarding the Binding Efficiency Index (BEI), the reference values should be in the range of 20 and 27 kDa.Since BEI values of compounds 24, 25, 31, 32, 33, 34, 35, 38, 39, and 47 are within such reference range, it appears that the ligands reveal a high structureactivity relationship with CYP2C9 and xanthine oxidase (see ...
Valeriana pilosa is usually employed in Peruvian folk medicine in the form of infusion to treat stomach pain, and has antispasmodic, relaxing, sleep-promoting, and sedative properties, as well as is an anti-inflammatory. In this study, Valeriana pilosa essential oil (VPEO) was obtained by hydrodistillation, analyzed by GC and GC/MS, and 47 compounds were identified. Major oil components were α-patchoulene (5.8%), α-humulene (6.1%), seychellene (7.6%), and patchoulol (20.8%). Furthermore, we assessed the in vitro antioxidant activities, molecular docking, and Ligand Efficiency studies on enzymes involved in cellular redox pathways such as CYP2C9, catalase, superoxide dismutase, and xanthine oxidase. Essential oil antioxidant activities were assessed by FRAP, ABTS•+, and DPPH• radical scavenging activity. VPEO displays high antioxidant activity as compared to essential oils of Valeriana jatamansi and Valeriana officinalis oil roots. In addition, molecular docking and ADMET prediction was employed to compare the absorption, metabolism, and toxicity properties of Valeriana pilosa compounds. In the molecular docking studies, limonene, p-cimene, carvone, α-cubebene, cyclosativene, α-guaiene, allo-aromadendrene, valencene, and eremophyllene were the compounds with the best docking score on CYP2C9 and xanthine oxidase. Thus, volatile components of Valeriana pilosa could be associated with the detected antioxidant activity, acting as putative inhibitors of CYP2C9 and xanthine oxidase.
... Other reports agree with our results by reporting limonene as a compound of Thymus vulgaris [60][61][62]. Limonene is widely used in the pharmaceutical industry as insecticide and antimicrobial [63][64][65][66][67]. Few studies have analyzed the antimicrobial effects of limonene; however, there are some works that evaluated the biological activity of limonene against species of genera like Aspergillus, Trichophyton, and Candida, reporting the antifungal efficiency of this compound [68,69]. ...
In the last three decades, invasive fungal infections caused by Candida species have become an important public health problem, because they are associated with high rates of morbidity and mortality in immunocompromised and hospitalized patients. The diagnosis and treatment of candidiasis are difficult and usually inefficient. Accordingly, a diversity of available drugs, currently employed to attack candidiasis, frequently induce resistance in patients promoting toxicity due to long-term treatments. Therefore, development of accurate diagnoses and novel antifungals is of high priority to improve life’s quality and expectancy of individuals infected with this pathogen. Plants are invaluable sources of new biologically active compounds. Among the plants used in Mexico in traditional herbolary medicine which have empirically been demonstrated to have antifungal activity are Pedilanthus tithymaloides, Thymus vulgaris, and Ocimum basilicum. In the present study, we analyzed whether these plants contain metabolites with antifungal activity against five Candida species. The extracts from the different plant organs were obtained by macerating them in ethyl alcohol or hexane and filtering. The obtained extracts were preserved in amber flasks at 4°C until used. The minimum inhibitory concentrations (MICs) of the active compound were determined by a microdilution assay. In addition, the following secondary metabolites were identified: linalool (3,7-dimethylocta-1,6-dien-3-ol), eugenol (4-allyl-2-methoxyphenol), limonene (1-methyl-4-(1-methylethenyl)-cyclohexene), and borneol ([(2R)-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl] formate). All these compounds were found in the three plants, traditionally used in everyday life, and proved to be effective against Candida species and therefore a viable alternative to conventional antifungals.
... The vast array of compound synthesis in the L. camara plant points out the adaptive significance for such a diversity of compounds. The variability for the essential oil (EO) composition of L. camara can be related to geographical distribution and pressures (Agil & Hosseinian, 2012;Benites et al., 2009;Javier, Ocampo, Ceballo, & Javier, 2017;Khan et al., 2016;Murugesan, Senthilkumar, Suresh Babu, & Rajasugunasekar, 2016;Pereira et al., 2019;Zoubiri & Baaliouamer, 2012). The metabolism and accumulation of secondary metabolites reflect the integrated influences of multiple ecological factors on the plant during their developmental and growth periods in addition to genetic factors (Liu et al., 2016). ...
Studies examining the variability in wild plant metabolic expression propose that environmental factors significantly influence the essential oil (EO) quality and quantity in a plant. Lantana camara is a widely distributed invasive plant species worldwide. However, its immense metabolites can become a source of novel compounds to produce biopesticides in the agricultural industry. Although, the quality aspect has to be considered due to the environmental influence on the metabolites synthesised. Therefore, this research aimed to understand the influence of environmental factors and how it shapes the plant’s metabolite profile in multiple populations of L. camara. Leaf samples were collected from six different geographic regions of Kenya and the corresponding monthly climatic data and soil samples. GC-MS data from leaf EO were analysed with environmental variables (climate and soil data) using unimodally unconstrained and constrained ordination methods for untargeted metabolomics analysis. Partial Least Squares-Discriminant Analysis (PLS-DA) and Random Forests (RF) were used to confirm the variability further. Seasonal and regional variability was observed for secondary metabolites (SMs) in the leaf EO, which correlated to climatic factors and soil attributes. We highlight the season-al-geographic metabolism relationship for L. camara and the combined analytical approach to obtain data that contributes to understanding the influence of environmental factors on the synthesis and accumulation of SMs. This research will have all-embracing implications for maximising phytochemical uniformity.
... Alpha-pinene, caryophyllene, β-pinene, and camphene were also reported in L. camara [42]. Volatile constituents such as caryophyllene oxide, eucalyptol, caryophyllene, and α-terpineol are present in the EO of this medicinally important plant species [43][44][45][46][47][48][49]. ...
The chemical composition of Lantana camara essential oil (EO), its insecticidal activities, and its impact on some biological parameters of the oriental latrine blowfly Chrysomya megacephala was assessed. The chemical composition of the tested EO was analyzed by gas chromatography and mass spectroscopy. Totally, 58 compounds corresponding to 99.8% of the total oil were identified, and major constituents of EO were α-pinene (15.3%), caryophyllene (15.28%), eucalyptol (7.8%), camphene (6.05%), caryophyllene oxide (5.33%), β-pinene (4.8%), and geranyl acetate (4.3%), citral (1.36%), α-terpineol (1.23%), tricyclene (0.613%), and linalool (0.62%). The dip toxicity test against the larvae of C. megacephala resulted in the disruption of metamorphosis, leading to developmental deformities, reduced pupariation rate, and inhibition of adult emergence. Lantana camara EO also resulted in larval and pupal toxicity, abnormal pupariation, non-viable pupal-adult intermediates production, and adultoid formation. Our result manifests that this Eo is acting as a juvenoid. This work supports the use of biological control methods for the control of medico-veterinary important insects.
... During the last decade, we have explored the biological properties of several medicinal plants commonly used by the Chilean and Peruvian Andean highlands communities [10][11][12][13][14]. In this work, we focus on the genus Clinopodium, Lamiaceae familiy, one of the richest species among the Angiosperms that includes 135 perennial herbs [15] and is frequently used for its medicinal properties. ...
Clinopodium sericeum is widely used in Peruvian folk medicine in the form of infusion to treat stomach distress, indigestion and antiflu. In this study, the essential oil from C. sericeum was obtained by hydrodistillation, analyzed by GC and GC/MS, and 73 compounds were identified. Major components of the oil were b-germacrene-D (15%), b-caryophyllene (13.8%), and sabinene (11.2%). Furthermore, we assessed the in vitro biological activities displayed by the oil obtained from the aerial parts of C. sericeum, namely the antioxidant, antimicrobial and antiproliferative activities. The antioxidant activities of the essential oil were evaluated by FRAP, CUPRAC, ABTS and DPPH radical scavenging activity. The essential oil displays antibacterial activity against Gram-negative and Gram-positive bacterial strains (MIC 50-200 µg/mL) in a dose-range close to standard antibiotics. Such activity may be related to the presence of terpene compounds. The antiproliferative activity of the essential oil was measured in vitro using the MTT colorimetric assay in healthy non-tumorigenic cells (HEK-293) and in three human cancer cell lines (T24, DU-145, and MCF-7). The calculated IC50 values were around 0.2 mg/mL. Since the essential oil was almost devoid of antioxidant activity, its anti-proliferative action is unlikely related to oxidative stress and relies on other unknown mechanisms.
