Fig 1 - uploaded by Reinhard Neier
Content may be subject to copyright.
Labeling used for nuclear magnetic resonance assignment
Source publication
The macrocyclisation of hydroxyethylfuranyl acetic acid and of dehydrogenated model compounds of nonactic acid was investigated to develop a facile synthesis of nonactin analogues. By applying the Yamagushi macrocyclisation to our ω-hydroxyacids, we were able to isolate a mixture of di-, tri-, tetra- and pentameric macrocycles.
Graphical abstract
Similar publications
The present work covers the recent synthetic of 2-benzamido-2-(1H-benzoimidazol-1-ylmethoxy) acetic acid in high yield
through alkaline hydrolysis reaction of methyl 2-benzamido-2-(1H-benzimidazol-1-ylmethoxy) acetate. This latter was
obtained through O-alkylation reaction between methyl α-bromo glycinate N-benzoylated and 1H-benzimidazol-1-
ylmeth...
Citations
Macrotetrolide α (1), a designed polynactin analog composed of (+)- and (−)-bishomononactic acids, was synthesized. The monomeric acids were prepared using cis-selective iodoetherification and optical resolution of the corresponding O-acetylmandelates as the key steps. Esterification and macrolactonization of the monomers were performed by Corey–Mukaiyama–Gerlach method. Compound 1 showed no immunosuppressive activity contrary to other natural polynactin congeners.
