Fig 4 - uploaded by Lucile Floeter Winter
Content may be subject to copyright.
5 L-arginine traffi c through macrophages infected with Leishmania. Arginine is taken up by macrophage (Mø) through CAT-2B membrane transporter. In the cytoplasm of the Mø the amino acid is metabolized by Mø's arginase (ARG II) or iNOS, or is taken up by parasitophorous vacuolum (PV) through an unknown mechanism. In order to achieve Leishmania 's arginase (ARG), L-arginine must be taken up by parasite through the AAP3 transporter and then must reach the glycosome (g) by unknown mechanisms
Similar publications
This study was aimed to evaluate the protective effect of chitosan (CS) against hypercholesterolemia (HC) induced arginase activation and disruption of nitric oxide (NO) biosynthesis using erythrocytes as cellular model. Human erythrocytes were isolated and classified into eight groups. Next, cells were treated with L-arginine (L-ARG), Nω-nitro- L-...
Hypoxia-induced pulmonary arterial hypertension (HPAH) is a refractory disease characterized by increased proliferation of pulmonary vascular smooth cells and progressive pulmonary vascular remodeling. The level of nitric oxide (NO), a potential therapeutic vasodilator, is low in PAH patients. L-arginine can be converted to either beneficial NO by...
Background & objectives:
High expression of arginase gene and its elevated level in serum and bronchial lavage reported in animal models indicated an association with the pathogenesis of asthma. This study was undertaken to assess the serum arginase activity in symptomatic asthma patients and healthy controls and to correlate it with cytokine leve...
Glucocorticoids are among the most effective drugs to treat asthma. However, the severe adverse effects associated generate the need for its therapeutic optimization. Conversely, though histamine is undoubtedly related to asthma development, there is a lack of efficacy of antihistamines in controlling its symptoms, which prevents their clinical app...
Background
Serum arginase levels have been shown to be elevated in conditions, such as trauma, cancer, chronic wounds, pregnancy, and diabetes. This also has been found to be true in atopic diseases, such as asthma and allergic rhinitis.
Objective
To study arginase activity in patients with atopic dermatitis (AD).
Methods
In this pilot study, arg...
