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Keeled-sternum angles. Keeled-sternum angles were measured using a 3-point arc on the caudal sternum curve. Larger angles indicate flatter keels, with 180 ? equaling a straight line. Keeled-sternums from PT chicks were flatter (Panel A; 166 ? ?8.23 ? , n = 13) than VT chicks (Panel B; 148 ? ?9.62 ? , n = 13; P = 0.000).
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“Broiler-type” chickens are fast-grow-ing, heavy-bodied birds with high demands on bone quality. Phenamil increased mineralization in cultured murine mesenchymal stem cells. Phenamil effects were tested in 2 groups of weight and gender matched day-old broiler chickens (n = 13). Oral administration of 30 mg phenamil/kg body weight d 1 to 13 reduced...
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Context 1
... compact bone cross-sectional thickness of H&E-stained bone were 0.037 (? 0.009) mm in PT chicks, thinner than the 0.045 ? 0.005 mm average of VT chicks (P = 0.008; Table 3, Figure 2). Relative abundance of osteoid and cartilage tissues could not be quantified due to extensive tissue tearing in multiple samples. Caudal hemisphere angles of keeled-sternums (Table 3, Figure 3) from PT chicks were noticeably flat- ter, averaging 166 ? ? 8.23 ? as compared to the 148 ? ? 9.62 ? average angle of VT chicks (P = ...
Citations
... WT-161 is a potent histone deacetylase 6 (HDAC6) inhibitor widely used in cancer treatment by targeting the expression of CD38 (Garcia-Guerrero et al., 2021;. Phenamil is an amiloride derivative involved in cell differentiation and primarily acts as a sodium channel blocker in various diseases (Garvin et al., 1985;Price et al., 2017). Metyrapone, a bipyridyl compound, is a reversible inhibitor of cytochrome P450. ...
Tuberculosis (TB) is a common infectious disease linked to host genetics and the innate immune response. It is vital to investigate new molecular mechanisms and efficient biomarkers for Tuberculosis because the pathophysiology of the disease is still unclear, and there aren’t any precise diagnostic tools. This study downloaded three blood datasets from the GEO database, two of which (GSE19435 and 83456) were used to build a weighted gene co-expression network for searching hub genes associated with macrophage M1 by the CIBERSORT and WGCNA algorithms. Furthermore, 994 differentially expressed genes (DEGs) were extracted from healthy and TB samples, four of which were associated with macrophage M1, naming RTP4, CXCL10, CD38, and IFI44. They were confirmed as upregulation in TB samples by external dataset validation (GSE34608) and quantitative real-time PCR analysis (qRT-PCR). CMap was used to predict potential therapeutic compounds for tuberculosis using 300 differentially expressed genes (150 downregulated and 150 upregulated genes), and six small molecules (RWJ-21757, phenamil, benzanthrone, TG-101348, metyrapone, and WT-161) with a higher confidence value were extracted. We used in-depth bioinformatics analysis to investigate significant macrophage M1-related genes and promising anti-Tuberculosis therapeutic compounds. However, more clinical trials were necessary to determine their effect on Tuberculosis.
