Karyotypes A of peripheral blood from an ALL patient (model ID: LD1-0041-362,073) and of a mouse peripheral blood from the LD1-0041-362,073 PDOX model. B Karyotypes of bone marrow from an ALL patient (model ID: LD1-1041-362,519) and of b mouse bone marrow from the LD1-1041-362,519 PDOX model. C Karyotypes of bone marrow of an ALL patient (model ID: LD1-0041-362,021) and c mouse bone marrow of the LD1-0041-362,021 PDOX model

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Procedures for PDOX establishment using AML/ALL samples

Establishment of PDOX Model in NCG mice. Cell suspensions prepared from...

Karyotypes A of peripheral blood from an ALL patient (model ID:...

Standard of care validation in PDOX models. AML PDOX (LD1-0040-361,280)...

Patient-derived intrafemoral orthotopic xenografts of peripheral blood or bone marrow from acute myeloid and acute lymphoblastic leukemia patients: clinical characterization, methodology, and validation

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Sep 2022

Acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) are malignant clonal diseases of the hematopoietic system with an unsatisfactory overall prognosis. The main obstacle is the increased resistance of AML and ALL cells to chemotherapy. The development and validation of new therapeutic strategies for acute leukemia require preclinica...