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Kaplan Meier curves of nutritional indicators. a. Classification BMI in CRC. b. Classification NRS in CRC. c. Classification PG-SGA in CRC d. Classification Phase angle in CRC. e. Classification VAT in CRC. f. Classification sarcopenia in CRC
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Background:
The prognosis of colorectal cancer (CRC) patients can be influenced by genetic mutations and nutritional status. The relationship between these variables is unclear. The objective of the study was to verify the variables involved in the nutritional status and genetic mutations, which correlate with survival of CRC patients.
Methods:...
Context in source publication
Context 1
... had a shorter survival time than patients with the wild type gene, except for NRAS, BRAF, and EGFR mutations (Table 2). However, these differences were not significant. All nutritional indicators (BMI, nutritional screening, PG-SGA, phase angle, VAT, and sarcopenia) were significantly associated with a higher risk of mortality (all p < 0.05, Fig. 2), except VAT/SAT (p = 0.366) (Table ...
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Introduction:
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Material and methods:
Seventeen patients...
Citations
... Furthermore, present study con rmed that APC, RAS, PIK3CA and EGFR were closely related to the tumorigenesis and development of CRC, and the incidence among the 82 patients with CRC was 58.5%, 47.6%, 34.1% and 30.4%, respectively. The somatic mutation pro le was basically consistent with the results of the previous study initiated by MAV Cavagnari and colleagues [41]. They also used NGS technique to implement the relevant somatic mutant genes based on the DNA extracted from frozen or para nembedded tumor tissues. ...
... With regard to the TMB analysis, the results of this study exhibited that the overall somatic mutation burden of the 82 patients was relatively low with a median TMB of 3.9/Mb (range: 0-48.6/Mb), which was similar with two colorectal cancer studies reported previously [22,41]. The median TMB in 516 patients with CRC patients of the DW's study was 4.5/Mb, while the median TMB in 29 patients with CRC of the MG's study was approximately 5.0/Mb. ...
... The TMB in DW Lee's team was distinguished by 7/Mb, and the proportion of patients with TMB-H was only 10.7%, which might contribute to the difference in prognosis [22]. However, TMB analysis of our study was basically consistent with that of the previous study initiated by MAV C and colleagues, which exhibited that the median OS of patients with TMB ≥ 5 and TMB < 5 was 33.6 and 41.0 months, respectively, even the difference was not statistically signi cant (P > 0.05) [41]. Furthermore, a recent study by LB Xu and colleagues found that soft tissue sarcoma patients with high TMB conferred a worse prognosis when received conventional adjuvant chemotherapy, which was consistent with the results of our study as well [25]. ...
Background: This study aimed to investigate the prognostic implications of tumor mutation burden (TMB) in patients with colorectal cancer (CRC) who underwent surgical resection and capecitabine-based adjuvant chemotherapy.
Methods: A total of 82 patients with CRC who underwent surgical resection and capecitabine-based adjuvant chemotherapy were included in this study retrospectively. Tumor tissue specimens were collected for DNA extraction after surgical resection. Somatic mutation detection and TMB analysis were performed using next-generation sequencing (NGS) of tumor-related genes. The recurrence status of the patients was assessed in the hospital during the adjuvant chemotherapy period, and the long-term survival data of patients were obtained by telephone follow-up. The univariate analysis between TMB status and prognosis was carried out by Kaplan-Meier survival analysis and adjusted by multivariate Cox regression analysis subsequently.
Results: The median follow-up period of this study was 5.3 years (range: 0.25-9.6 years). The median disease-free survival (DFS) of the 82 patients was 4.5 years, the median overall survival (OS) was 5.7 years. The results of NGS analysis demonstrated that the most common mutated somatic genes among the 82 patients were TP53, APC, RAS, PIK3CA and EGFR, and the prevalence was 62.2%, 58.5%, 47.6%, 34.1% and 30.4%, respectively. Other somatic mutant genes were of relatively low frequency (<30%). Regarding the TMB analysis, the overall somatic mutation burden of the 82 patients was comparatively low [median: 3.9/Mb (range: 1.6-48.6/Mb)]. TMB status was divided into TMB-L (≤3.9/Mb) and TMB-H (>3.9/Mb) according to the median TMB threshold. And the patients with TMB-L and TMB-H were observed in 42 cases and 40 cases, respectively. Prognostic analysis according to TMB status demonstrated that the median OS of patients with TMB-L and TMB-H was 6.5 and 4.5 years, respectively (P=0.009). Additionally, in order to adjust the confounding factors that might influence OS, a multivariate Cox regression analysis was introduced and the results exhibited that TMB status was an independent factor for OS (HR=0.71, P=0.011).
Conclusion: TMB might be considered as a potential biomarker for predicting the prognosis of patients with CRC who underwent surgical resection and capecitabine-based adjuvant chemotherapy. Results of this study should be elucidated in large-scale prospective clinical trial subsequently.
... Although the mechanism of CRC carcinogenesis has been studied for a long time, it still remains unclear. To the best of our knowledge, the mutations and/or dysregulation of oncogenes (e.g., KRAS, BRAF, and PIK3CA) [6] or antioncogenes (e.g., APC and PETN) [7] play an important role in the pathological process of CRC by activating carcinogenic signaling pathways, among which the PI3K/AKT pathway is an important one [8]. Aberrant activation of the PI3K/AKT pathway is a major feature in the process of driving CRC carcinogenesis [9]. ...
Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive system, and represents a severe threat to the life and health of individuals. Increasing evidence supports the role of small nucleolar RNAs (snoRNAs) as critical regulatory gene in cancer development. Small Cajal body-specific RNAs (scaRNAs), a subtype of snoRNAs, are named for their subcellular localization within Cajal bodies. SCARNA12, which located at the intronic region of PHB2 in chromosome 12p13.31 with 270 nucleotides (nt) in length. It has been reported function as a diagnostic marker for cervical cancer. However, its biological functions and molecular mechanisms in CRC have yet to be elucidated. In this study, bioinformatics analysis revealed that SCARNA12 was highly expressed in CRC and positively correlated with poor prognosis in CRC patients. Additionally, SCARNA12 showed upregulated expression in CRC cell lines and clinical CRC tissue samples. Moreover, SCARNA12 overexpression in SW620 cells accelerated cell proliferation, suppressed the apoptosis rate, and enhanced tumorigenesis in vivo. The knockdown of SCARNA12 expression in HCT116 and HT29 cells resulted in contrasting effects. The functioning of SCARNA12 is mechanically independent of its host gene PHB2. Notably, the overexpression of SCARNA12 activated PI3K/AKT pathway in SW620 cells, and the malignancy degree of CRC cells was attenuated after treatment with MK2206 (a specific AKT inhibitor). Our findings demonstrated that SCARNA12 plays an oncogenic role in CRC progression and can be used as a potential diagnostic biomarker for CRC.
Supplementary Information
The online version contains supplementary material available at 10.1186/s43556-023-00147-x.
... The cancer-associated systemic inflammatory response is a critical indicator of tumor progression, and patients with CRC and higher levels of inflammation have a higher risk of death than those with lower levels of inflammation (4,6). Nutritional status also plays an important role in the prognosis of patients with CRC, with several studies indicating that poor nutrition is linked to poorer overall survival (OS) for patients with CRC (7)(8)(9). In addition, good immune function is the main defense against CRC progression. ...
... In our study, a lower CALLY index (representing higher CRP) was associated with a higher risk of death in patients with CRC, which is consistent with research and theories mentioned above. In addition to inflammation, the roles of nutrition status in the occurrence and development of CRC could not be ignored (7,8). On one hand, CRC cells affect the absorption and utilization of nutrients through inflammation and metabolic processes, making patients with CRC are prone to malnutrition (25, 26). ...
Background
Colorectal cancer (CRC) is among the most common malignant cancers worldwide, and its development is influenced by inflammation, nutrition, and the immune status. Therefore, we combined C-reactive protein (CRP), albumin, and lymphocyte, which could reflect above status, to be the CRP-albumin-lymphocyte (CALLY) index, and evaluated its association with overall survival (OS) in patients with CRC.
Methods
The clinicopathological and laboratory characteristics of 1260 patients with CRC were collected from the Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) study. Cox regression analysis was performed to assess the association between the CALLY index and OS. A nomogram including sex, age, the CALLY index and TNM stage was constructed. The Concordance Index (C-index) was utilized to evaluate the prognostic value of the CALLY index and classical CRC prognostic factors, such as modified Glasgow prognostic score (mGPS), neutrocyte to lymphocyte ratio (NLR), systemic immune inflammation index (SII), and platelet to lymphocyte ratio (PLR), as well as to assess the prognostic value of the nomogram and TNM stage.
Results
Multivariate Cox regression analyses demonstrated that the CALLY index was independently associated with OS in patients with CRC [Hazard ratio (HR) = 0.91, 95% confidence interval (CI) = 0.87-0.95, P<0.001]. The CALLY index showed the highest prognostic value (C-index = 0.666, 95% CI = 0.638-0.694, P<0.001), followed by mGPS, NLR, SII, and PLR. The nomogram demonstrated higher prognostic value (C-index = 0.784, 95% CI = 0.762-0.807, P<0.001) than the TNM stage.
Conclusion
The CALLY index was independently associated with OS in patients with CRC and showed higher prognostic value than classical CRC prognostic factors. The nomogram could provide more accurate prognostic prediction than TNM stage.
... SMD reflects the lipid content of the muscle cells; lower SMD is associated with higher muscle cell lipid content [18]. Studies show that at diagnosis, about 30-40% of CRC patients already have low SMD, 43% had low SMI, and 64% have a high percentage of visceral adipose tissue (VAT) [19][20][21][22]. A study in patients with different tumor types showed that a low muscle mass was associated with more chemotoxicity. ...
Background
Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect among colorectal cancer (CRC) survivors, and the severity is mainly dependent on the chemotherapy dose. Nowadays, chemotherapy dose is based on body surface area, while determination based on more accurate measures of body composition may be better. This study aimed to investigate the association between body composition and long-term CIPN among CRC survivors 2–11 years after diagnosis.
Methods
Data from CRC survivors from the population-based PROFILES registry were used. Survivors were included when they received chemotherapy, filled in the EORTC QLQ-CIPN20, and had a computed tomography (CT) scan at diagnosis ( n = 202). Total, sensory, motor, and autonomic CIPN were based upon the EORTC QLQ-CIPN20. The abdominal CT scans were used to determine skeletal muscle index (SMI), skeletal muscle density (SMD), visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and total adipose tissue (TAT). Logistic regression was used to analyze the association between CIPN outcomes and body composition variables.
Results
CIPN was experienced by 64% of the CRC survivors several years after chemotherapy. More SAT was associated with a higher odds of reporting total CIPN (OR = 1.01 95% CI 1.00–1.01, p = 0.01), motor CIPN (OR = 1.01 95% CI 1.00–1.01, p = 0.01), and sensory CIPN (OR = 1.01 95% CI 1.00–1.01, p = 0.04). No associations of other body composition parameters with CIPN were observed.
Conclusion
Only SAT was associated with total, motor, and sensory CIPN. Based on these results, we cannot conclude that determining the chemotherapy dose based on body composition is preferred over determining the chemotherapy dose based on body surface to prevent CIPN. More research is needed to assess associations of body composition with CIPN, a common side effect of chemotherapy.
... Since there is no standardized cut-off value for VFA, some western studies used top sex-specific quartile to define visceral obesity patients (31). Other western studies considered defining visceral obesity with VFA >163.8 cm 2 in males and >80.1 cm 2 in females as cut points coming from a white population undergoing gastrointestinal resection (32). As the body composition differs from distinct regions, the results of these study may not be applicable to Asian population. ...
Background
The impact of visceral obesity on the postoperative complications of colorectal cancer in elderly patients has not been well studied. This study aims to explore the influence of visceral obesity on surgical outcomes in elderly patients who have accepted a radical surgery for colorectal cancer.
Methods
Patients aged over 65 year who had undergone colorectal cancer resections from January 2015 to September 2020 were enrolled. Visceral obesity is typically evaluated based on visceral fat area (VFA) which is measured by computed tomography (CT) imaging. Univariate and multivariate analyses were performed to analyze parameters related to short-term outcomes.
Results
A total of 528 patients participated in this prospective study. Patients with visceral obesity exhibited the higher incidence of total (34.1% vs. 18.0%, P < 0.001), surgical (26.1% vs. 14.6%, P = 0.001) and medical (12.6% vs. 6.7%, P = 0.022) complications. Based on multivariate analysis, visceral obesity and preoperative poorly controlled hypoalbuminemia were considered as independent risk factors for postoperative complications in elderly patients after colorectal cancer surgery.
Conclusions
Visceral obesity, evaluated by VFA, was a crucial clinical predictor of short-term outcomes after colorectal cancer surgery in elderly patients. More attentions should be paid to these elderly patients before surgery.
... Muscle mass evaluation in the early phases of treatment is a relevant factor in oncological outcomes (6,27) and muscle depletion can be considered a modifiable risk factor in patients with CRC (22,27) . The body composition assessment by CT enables a more accurate diagnosis of sarcopenia, myopenia, and visceral fat obesity as well as changes in body composition and is considered the gold standard for nutritional screening of patients with CRC (5,6,8,(10)(11)(12)(13)(14)17,19,20,22,23) . ...
... CT is performed for diagnosis and staging of the disease and can also be used to assess body composition of patients with CRC (8,(10)(11)(12)(13)(14)(17)(18)(19)(20)23) , although is seldom used. The examiners must have experience in anatomical radiology and be trained to select tissues for the correct analysis (11,12,17,20,28) . ...
... CT is performed for diagnosis and staging of the disease and can also be used to assess body composition of patients with CRC (8,(10)(11)(12)(13)(14)(17)(18)(19)(20)23) , although is seldom used. The examiners must have experience in anatomical radiology and be trained to select tissues for the correct analysis (11,12,17,20,28) . ...
Background:
The nutritional status of patients with colorectal cancer (CRC) impacts on treatment response and morbidity. An effective evaluation of the body composition includes the measurements of fat and visceral fat-free mass and is currently being used in the diagnosis of the nutritional status. The better understanding regarding nutritional tools for body composition evaluation in CRC patients may impact on the outcome.
Methods:
Systematic review conducted according to Preferred Items of Reports for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. A literature search was performed using the BVS (LILACS), PubMed, Embase, Cochrane, Scopus, and Web of Science databases.
Results:
For the initial search, 97 studies were selected and 51 duplicate manuscripts were excluded. Thus, 46 were reviewed and seven studies included with a total of 4,549 patients. Among them were one clinical trial, one prospective study (cohort), two retrospective cohort and two cross-sectional studies. All studies included body composition evaluated by computed tomography, one with bioelectrical impedance, one with handgrip strength, and two employed mid-arm muscle circumference and body mass index.
Conclusion:
Current evidence suggests that computed tomography has better accuracy in the diagnosis of sarcopenia, visceral fat, and myopenia among individuals with CRC. Further studies are needed to identify cutoff points for these changes aggravated by CRC.
... C, 2018). Thus, the survival prediction at an early stage is helpful in many ways, such as; 1) the surgical intervention could be reduced, 2) treatment could be altered based on body mass index and nutritional screening (Cavagnari, 2019) to avoid rapid cell proliferation caused by nutrient deprivation, 3) medication and therapies targeting proteins and the related mutations could be introduced, 4) the survival-predicting biomarkers responsible for oral cancer could be learned, and 5) mutation-driven drug discoveries could be made. Further, these predictions and classifications could help clinicians and oncologists determine the patients' mortality rate and alter the prognosis procedure to better deal with cancer patients. ...
Background: For years now, cancer treatments have entailed tried-and-true methods. Yet, oncologists and clinicians recommend a series of surgeries, chemotherapy, and radiation therapy. Yet, even amidst these treatments, the number of deaths due to cancer increases at an alarming rate. The prognosis of cancer patients is influenced by mutations, age, and various cancer stages. However, the association between these variables is unclear.
Methods: The present work adopts a machine learning technique—k-nearest neighbor; for both regression and classification tasks, regression for predicting the survival time of oral cancer patients, and classification for classifying the patients into one of the predefined oral cancer stages. Two cross-validation approaches—hold-out and k-fold methods—have been used to examine the prediction results.
Results: The experimental results show that the k-fold method performs better than the hold-out method, providing the least mean absolute error score of 0.015. Additionally, the model classifies patients into a valid group. Of the 429 records, 97 (out of 106), 99 (out of 119), 95 (out of 113), and 77 (out of 91) were classified to its correct label as stages – 1, 2, 3, and 4. The accuracy, recall, precision, and F-measure for each classification group obtained are 0.84, 0.85, 0.85, and 0.84.
Conclusions: The study showed that aged patients with a higher number of mutations than young patients have a higher risk of short survival. Senior patients with a more significant number of mutations have an increased risk of getting into the last cancer stage
... Đối tượng tham gia nghiên cứu có những đặc điểm chung tương đồng so với các nghiên cứu về dinh dưỡng bệnh nhân ung thư tại Việt Nam và trên thế giới với độ tuổi trung bình cao trên 60 tuổi, trình độ học vấn chủ yếu từ trung học cơ sở trở lên và hơn 50% bệnh nhân ung thư giai đoạn III và IV [3], [4], [5], [6]. ...
... Tình trạng suy dinh dưỡng ở bệnh nhân UTĐTT trong nghiên cứu này tính theo phương pháp PG-SGA là 85,44%; kết quả này cao hơn so với các nghiên cứu về tình trạng dinh dưỡng ở bệnh nhân UTĐTT của Đào Duy Tân, Cavagnari và Gillis với tỷ lệ lần lượt là 52,3%; 56,6% và 60,9% [4], [6], [7]. Tương tự, kết quả này cũng cao hơn so với tỷ lệ suy dinh dưỡng đã báo cáo tại bệnh viện K và bệnh viện Trung ương Thái Nguyên với thang đo PG-SGA trên bệnh nhân ung thư đường tiêu hóa nói chung với tỷ lệ lần lượt là 58,6% và 61,9% [5], [8]. ...
... Tương tự như các nghiên cứu đánh giá về tình trạng dinh dưỡng, nhìn chung các nghiên cứu đều cho thấy tỷ lệ suy dinh dưỡng đánh giá bởi thang điểm PG-SGA cao hơi so với phân loại bằng chỉ số BMI [4], [5], [6]. Tỷ lệ suy dinh dưỡng theo thang BMI trong nghiên cứu này là 19,42% thấp hơn so với các nghiên cứu của Lê Thị Vân, Nguyễn Thị Thanh và Phạm Thị Thanh Hoa với tỷ lệ là 38,1%; 26,0% và 35,2%; cao hơn so với nghiên cứu của Đào Duy Tân, Cavagnari [3], [4], [5], [6], [8]. ...
Tình trạng dinh dưỡng của bệnh nhân ung thư đại trực tràng (UTĐTT) ảnh hưởng đến hiệu quả điều trị, chất lượng cuộc sống và khả năng sống sót của bệnh nhân. Mục tiêu nghiên cứu: Xác định tỷ lệ và một số yếu tố liên quan đến suy dinh dưỡng (SDD) của bệnh nhân UTĐTT. Phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang trên 103 bệnh nhân UTĐTT tại khoa ngoại tổng hợp bệnh viện Thanh Nhàn và khoa ngoại chung bệnh viện Vinmec Times City từ tháng 9/2020 đến tháng 5/2021. Kết quả: Tỷ lệ bệnh nhân có nguy cơ suy dinh dưỡng hoặc suy dinh dưỡng trước phẫu thuật đánh giá theo thang PG-SGA là 85,44%, trong đó SDD nặng chiếm 60,19% và và thang BMI lần lượt là 19,42%. Các yếu tố tuổi cao, giới nữ, trình độ học vấn dưới trung học cơ sở và ung thư giai đoạn III và IV có ảnh hưởng tiêu cực đến sinh dưỡng bệnh nhân (p<0,05). Trong khi đó các yếu tố về vị trí ung thư, phương pháp điều trị, đường nuôi dưỡng và bệnh viện điều trị không có mối liên quan có ý nghĩa thống kê với tỷ lệ suy dinh dưỡng bệnh nhân (p>0,05). Kết luận: Nghiên cứu cho thấy bệnh nhân UTĐTT trước phẫu thuật có tỷ lệ SDD cao. Do đó, nhân viên y tế cần chú trọng đến sàng lọc tình trạng suy dinh dưỡng của bệnh nhân để đưa ra các biện pháp can thiệp, hỗ trợ kịp thời.
... Moreover, FBXW7 is one of the most frequently mutated genes during CRC initiation and progression [10]. Altered FBXW7 status (mutation and/or low expression) may be associated with prognosis in CRC, however, the results vary among different studies [11][12][13][14][15][16][17][18][19][20]. Thus, we conducted a systematic review and meta-analysis of data from previous studies to quantitatively assess the association between FBXW7 status and survival in CRC. ...
Background
Various studies investigating the clinical significance of FBXW7 mutation and/or expression have yielded inconclusive results in colorectal cancer (CRC) patients. Therefore, the present meta-analysis summarizes previous evidence and evaluates the clinical significance, including the prognostic role, of FBXW7 status in CRCs.
Methods
The meta-analysis was conducted by searching the databases of PubMed, China National Knowledge Infrastructure (CNKI), WANFANG data, Web of Science, Embase, and Web of Science. Pooled odds ratios (ORs) and hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) were calculated to assess the relationships between FBXW7 status and clinicopathological features and survival in CRC, respectively.
Results
Ten studies involving 4199 patients met the inclusion criteria and included in our meta-analysis. FBXW7 mutation/low expression was obviously correlated with advanced T stage (OR = 0.44, 95% CI: 0.27–0.74, P < 0.01) and lymph node metastasis (OR = 1.88, 95% CI: 1.40–2.53, P < 0.01), but was not associated with other parameters. Further investigation found that FBXW7 mutation/low expression predicted poor OS (HR = 1.25, 95% CI: 1.06–1.47, P < 0.01), but not DFS in CRC (HR = 1.04, 95% CI: 0.60–1.82, P = 0.88). Subgroup analysis found that FBXW7 status was obviously correlated with OS in cohorts recruited after 2009 (HR = 1.32, 95% CI: 1.17–1.50, P < 0.01), from eastern Asia (HR = 1.27, 95% CI: 1.04–1.55, P = 0.02), detected by immunohistochemistry/qRT-PCR (HR = 1.39, 95% CI: 1.22–1.59, P < 0.01), and analysed with multivariate method (HR = 1.47, 95% CI: 1.25–1.74, P < 0.01).
Conclusions
This study indicates that FBXW7 status, expression level especially, is associated with OS but not DFS in CRC. FBXW7 expression level may function as a prognostic biomarker in CRC.
... [10] Altered FBXW7 status (mutation and/or low expression) may be associated with prognosis in CRC, however, the results vary among different studies. [11][12][13][14][15][16][17][18][19][20] Thus, we conducted a systematic review and meta-analysis of data from previous studies to quantitatively assess the association between FBXW7 status and survival in CRC. ...
Background: Various studies investigating the clinical significance of FBXW7 mutation and/or expression have yielded inconclusive results in colorectal cancer (CRC) patients. Therefore, the present meta-analysis summarizes previous evidence and evaluates the clinical significance, including the prognostic role, of FBXW7 status in CRCs.
Methods: The meta-analysis was conducted by searching the databases of PubMed, China National Knowledge Infrastructure (CNKI), WANFANG data, Web of Science, Embase, and Web of Science. Pooled odds ratios (ORs) and hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) were calculated to assess the relationships between FBXW7 status and clinicopathological features and survival in CRC, respectively.
Results: Ten studies involving 4199 patients met the inclusion criteria and included in our meta-analysis. FBXW7 mutation/low expression was obviously correlated with advanced T stage (OR = 0.44, 95% CI: 0.27–0.74, P < 0.01) and lymph node metastasis (OR = 1.88, 95% CI: 1.40–2.53, P < 0.01), but was not associated with other parameters. Further investigation found that FBXW7 mutation/low expression predicted poor OS (HR = 1.25, 95% CI: 1.06–1.47, P < 0.01), but not DFS in CRC (HR = 1.04, 95% CI: 0.60–1.82, P = 0.88). Subgroup analysis found that FBXW7 status was obviously correlated with OS in cohorts recruited after 2009 (HR = 1.32, 95% CI: 1.17–1.50, P < 0.01), from eastern Asia (HR = 1.27, 95% CI: 1.04–1.55, P = 0.02), detected by immunohistochemistry/qRT-PCR (HR = 1.39, 95% CI: 1.22–1.59, P < 0.01), and analysed with multivariate method (HR = 1.47, 95% CI: 1.25–1.74, P < 0.01).
Conclusions: This study indicates that FBXW7 status, expression level especially, is associated with OS but not DFS in CRC. FBXW7 expression level may function as a prognostic biomarker in CRC.
