Intrinsic and extrinsic pathway of inflammation. Adapted from: Nakamura K, Smyth MJ. Targeting cancer-related inflammation in the era of immunotherapy [20].

Intrinsic and extrinsic pathway of inflammation. Adapted from: Nakamura K, Smyth MJ. Targeting cancer-related inflammation in the era of immunotherapy [20].

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El carcinoma de mama es una enfermedad común, con efectos negativos significativos en la salud predominantemente femenina. Los linfocitos infiltrantes al tumor (TILs) son una manifestación de la respuesta inmune del huésped al cáncer. Este estudio revisa y resume los reportes bibliográficos relacionados con la eficacia pronóstica del porcentaje alt...

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... later, it was described that the predictive value of TILs was associated with rapidly increasing tumors [26]. The molecular mechanisms that drive cancer-related inflammation can be summarized in the interference between two pathways: the intrinsic pathway, mediated by oncogene expression, and the extrinsic pathway, where inflammatory mediators and microenvironmental factors are involved ( Figure 1). These pathways regulate tumor survival, proliferation, angiogenesis, and immunosuppression [20,27,28]. ...

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