Fig 2 - uploaded by Karl Reinhard Aigner
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Intraoperative contrast imaging of two angiographic carotid artery catheters and balloon blocked aorta and vena cava.
Source publication
Introduction:
This is a report about the first case of an advanced stage IV tonsil carcinoma treated with isolated thoracic perfusion and chemofiltration.
Presentation of case:
The tumor extended beyond the midline with bilateral lymphnode metastases. Playing on wind instruments was impossible. As a professional Jazz saxophonist he refused mutil...
Context in source publication
Context 1
... the first isolated thoracic perfusion ( Fig. 1) on 7th December 2010 the chemotherapeutic agents were administered via two angiographically placed common carotid artery catheters (Fig. 2) at a dosage of totally 100 mg cisplatin, 60 mg adriamycin and 20 mg mitomycin followed by chemofiltration in order to reduce systemic toxicity. After a 15 min short-term carotid artery infusion of this three-drug combination into the isolated perfusion circuit, followed by 45 min of chemofiltration, the patient did not suffer any ...
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Background
Colorectal cancer is the fourth most diagnosed malignancy worldwide and surgery is one of the cornerstones of the treatment strategy. Near-infrared (NIR) fluorescence imaging is a new and upcoming technique, which uses an NIR fluorescent agent combined with a specialised camera that can detect light in the NIR range. It aims for more pre...
Citations
... For both malignancies, surgical resection with free margins was the main treatment option along with adjunct chemoradiation to achieve further local tumor control [5,9,10]. The use of regional chemotherapy as a potent therapy for tumor shrinkage has also been reported as a treatment modality [20]. ...
Introduction
The simultaneous occurrence of multiple primary malignancies in a patient has been widely reported. Oral mucosal malignant melanoma is a rare lesion of the oral cavity. The occurrence of this lesion with a very rare skin sarcoma at the same time has never to the best of our knowledge been reported previously.
Presentation of case
A 64 year-old Nigerian woman with a 27-year history of a dark lesion in the right maxillary buccal and palatal mucosa with an anterior abdominal swelling of 24 years which was discovered on systemic examination. Both lesions were later discovered to be malignant melanoma and dermatofibrosarcoma protuberans respectively. She had a right hemimaxillectomy for the maxillary lesion and wide excision of the abdominal wall lesion, followed by six courses of chemotherapy. She has been undergoing regular reviews for the past 5 years and remains free of all malignancy; however, she died shortly after noticing the reappearance of both lesions.
Discussion
While evaluating patients with a tumor, it will be rewarding to rule out other similar swellings in the body. This is important to avoid metastasis or multiple primary malignancies, which can help prolong patient life.
Conclusion
The synchronous occurrence of two different neoplastic lesions is rare. Our literature search revealed no previous report of such occurrence of oral malignant melanoma and DFSP at the same time in one patient. The importance of thorough examination of patients cannot be overemphasized as concurrent lesions may be missed.
ZUSAMMENFASSUNG
Ein 47-jähriger Patient mit einem die mediane Linie überschreitenden Zungengrundkarzinom im Stadium IVA wurde mit insgesamt drei Zyklen intraarterieller Chemotherapie über die linke und rechte A. carotis behandelt. Zur Toxizitätsprophylaxe wurde jeweils eine Chemofiltration im venösen Rückfluss aus dem Tumorareal durchgeführt. Die initial erschwerte orale Nahrungsaufnahme als auch Schmerzen im Stadium 3, waren zum Zeitpunkt der zweiten Therapie nahezu und zu Beginn der dritten Therapie völlig verschwunden. Der Tumor ist seit 55 Monaten in Komplettremission und der Patient völlig beschwerdefrei. Das Prinzip der gesteigerten Tumortoxizität der intraarteriellen Chemotherapie beruht auf der hohen Zytostatikaaufnahme bei der ersten Passage durch die Tumorgefäße.
Zusammenfassung
Ein 47-jähriger Patient mit einem die mediane Linie überschreitenden Zungengrundkarzinom im Stadium IVA wurde mit insgesamt drei Zyklen intraarterieller Chemotherapie über die linke und rechte A. carotis behandelt. Zur Toxizitätsprophylaxe wurde jeweils eine Chemofiltration im venösen Rückfluss aus dem Tumorareal durchgeführt. Die initial erschwerte orale Nahrungsaufnahme als auch Schmerzen im Stadium 3, waren zum Zeitpunkt der zweiten Therapie nahezu und zu Beginn der dritten Therapie völlig verschwunden. Der Tumor ist seit 55 Monaten in Komplettremission und der Patient völlig beschwerdefrei. Das Prinzip der gesteigerten Tumortoxizität der intraarteriellen Chemotherapie beruht auf der hohen Zytostatikaaufnahme bei der ersten Passage durch die Tumorgefäße.
