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Background: In an infant or child thrombocytopenia can occur due to large spectrum of illness ranging from tropical infection to malignancy or bone marrow failure. Management is decided by the severity of thrombocytopenia, associated risk factors and underlying illness. Children with thrombocytopenia may be asymptomatic – detected by complete blood...
Contexts in source publication
Context 1
... of 7 patients with enteric fever showed elevated ALT levels. P value is 1.67 (>0.05), hence is statistically significant (Table 3). ...Context 2
... study done by Bhalara, showed dengue (60.8%) as the main aetiology. 12 Table 3 shows distribution of patients according to the grades of thrombocytopenia in different infections. Out of 44 dengue patients, 16 (36%) had mild thrombocytopenia, 13 (30%) had moderate thrombocytopenia and 15 (34%) had severe thrombocytopenia. ...Similar publications
Abstract:
Background: Thrombocytopenia is a condition in which platelet (PLT) count becomes
less than normal range in some abnormal cases. The normal range of thrombocytopenia
varies from 150.000 to 450.000 cell/cm3
. There are some cases that lead to
pseudothrombocytopenia. The most common causes of Pseudothrombocytopenia
involving; instrument e...
Citations
... This is in concordance with studies by other workers. 6,8,[13][14][15] The higher incidence of thrombocytopenia in older children and males may be attributed to the prolonged outdoor activities by grown-up male children as compared to infants and girls, and hence Male to female ratio was 1.5:1. Nearly 45% of children (n = 111) were above 10 years of age, 24% (59) had an age between 5 and 10 years, 23.6 % (n = 58) were aged 1-5 years, and 7.3% (18) were infants (Table 1). ...
Aim: To study the clinico-etiological profile of children with thrombocytopenia. Methods: This prospective hospital-based study included all children (<18 years) with thrombocytopenia at the time of hospitalization and/or thrombocytopenia during the course of their hospital stay. A detailed history was recorded and appropriate laboratory investigations were carried out. Results: The study group comprised 246 children (mean age, 9.29 years; median age, 10 years) with male to female ratio of 1.5:1. Nearly 45% of children were above 10 years of age. Trends of admissions showed that the majority of children with thrombocytopenia (n = 115) got hospitalized during the rainy season, followed by summer (n = 84). Fever (72.8%), pallor (52.8%), bleeding manifestations (22%), lymphadenopathy (20.3%), and splenomegaly (20.3%) were common clinical features. Petechiae was the most common bleeding manifestation (63%). Septicemia (24%) was the most common etiology, followed by megaloblastic anemia (14.6%), undiagnosed fever (10.2%), local infection (9.3%), hepatitis (6.5%), and scrub typhus (6.1%). About nine children died. All those who died had septicemia and multi-organ dysfunction (MOD). On logistic regression analysis, age >10 years, presence of bleeding, arthralgia, rash, pallor, gastrointestinal (GI) symptoms, hematological disorders, and malignancy were associated with severe thrombocytopenia. Conclusion: Thrombocytopenia is a common hematological observation. This study revealed seasonal variation in the occurrence of thrombocytopenia in children, with the maximum number of cases in the rainy season. Septicemia is the commonest etiology. The majority of children with thrombocytopenia have no bleeding manifestations. Age >10 years, presence of bleeding, arthralgia, rash, pallor, GI symptoms, hematological disorders, and malignancy are associated with severe thrombocytopenia.
... 15,25 The other causes of thrombocytopenia can be infectious diseases like malaria, HIV/AIDS, nutritional deficiency such as folic acid, vitamin B 12 deficiency, and other disease conditions like leukemia and aplastic anemia. [26][27][28][29] Thrombocytopenia affects 6% to 10% of pregnant women worldwide and it is the most common hematological disorder in pregnant women during the gestation period. It affects around one-tenth of pregnant women in the world. ...
Background
Thrombocytopenia is a common hematological abnormality during gestation. Pregnant women with severe thrombocytopenia may be associated with a higher risk of excessive bleeding during or after delivery. Therefore, the main aim of this study was to assess the magnitude and associated factors of thrombocytopenia among pregnant women attending antenatal care services at Dessie comprehensive and specialized hospital, Northeast Ethiopia.
Methods
An institution-based cross-sectional study was conducted from February to March 2021. Using a systematic random sampling technique, a total of 294 pregnant women were enrolled in the study. Structured interviewer-administered questionnaires were used to collect socio-demographic and clinical data of study participants. Four ml of venous blood were collected from each pregnant woman and a complete blood count was determined using DIRUI BF 6500 automated hematology analyzer. Data were entered into Epidata version 4.6.0 and then exported into SPSS version 24.0. Multivariate logistic regression was used to assess the association between dependent and independent variables. P-value < 0.05 was considered to be statistically significant.
Results
A total of 294 pregnant women who visited antenatal care services at Dessie comprehensive specialized hospital were included. The mean (±SD) age of the study participants was 29.7 (±6.1) years. The prevalence of thrombocytopenia among pregnant women was 9.9% (95% CI: 6.5, 13.6). A mild type of thrombocytopenia is the major type and accounted for 72.4% whereas moderate thrombocytopenia and severe thrombocytopenia accounted for 17.2% and 10.4% respectively among pregnant women. Multivariate logistic regression showed that urban residents (AOR: 0.206,95% CI, 0.055-0.748), gestational ages within the first trimester (AOR: 0.183, 95% CI, 0.057-0.593) and gestational ages within the second trimester (AOR = 0.264, 95% CI, 0.092-0.752) were significantly associated and independent predictors of thrombocytopenia in pregnant women.
Conclusion
In this study, the prevalence of thrombocytopenia was 9.9% and the mild type of thrombocytopenia (72.4%) was higher than the other type of thrombocytopenia among pregnant women. In multivariate logistic regression analysis, residence and gestational age (trimester) were significantly associated with thrombocytopenia. Therefore, the platelet count should be routinely determined during the antenatal care visit for proper diagnosis and to minimize bleeding during and or after childbirth.
