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Increased basal pigmentation, pigmentary incontinence and melanophages (hematoxylin and eosin, 400×)
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... 7 7. Chik sign: Centro-facial distribution of pigmentation, especially involving the nose is one of the cutaneous manifestations of chikungunya fever. 8,9 Recently this sign has also been observed in dengue fever [ Figure 5]. 10 8. Comby sign: It is an initial sign of measles, comprising thin whitish patches on the gingiva and buccal mucosa, made up of desquamating epithelial cells. 7 9. Comet sign: Dermatitis caused by Pyemotes species (a parasite of the furniture beetle) presents as erythematous pruritic macules or urticated plaques surmounted by vesicles; occasionally they may be bullous. ...
A “sign” refers to the objective finding, which a clinician observes during the clinical examination of the patient. Signs implicate significant changes or abnormal findings which can assist the clinician in making the final diagnosis of any disorder. Cutaneous signs indicate various dermatological and systemic disorders and sometimes help the dermatologist in making a spot diagnosis. Various cutaneous signs have been described in many infectious disorders. Here, an attempt is made to compile various such cutaneous signs seen in infectious diseases.
