IVCM findings of the cornea in patients with RCEs. All images were obtained using the HRT-3-RCM system with a field of 400 µm × 400 µm. (A) Microcysts and gaps due to epithelial defects. (B) Elongated superficial cells and brightly reflective granular structures. (C) Increased activation of Langerhans cells. (D) Decreased corneal subbasal nerves. (E) Activated keratocytes in the shallow stroma. (F) Disorganized stroma fibers. (G) Infiltrated cells in the middle stroma. (H) Deposit on the endothelium.

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... shown in Figure 3, all RCE patients showed irregular arrangements of epithelial cells ( Figure 3B), bright reflective deposits in the epithelium ( Figure 3B) and Bowman's layer ( Figure 3C), enlarged basal epithelial cells ( Figure 3B), reduced corneal sub-basal nerves ( Figure 3D), activation of shallow stroma ( Figure 3E), and disorganized stroma fibers ( Figure 3F). Thirty-one patients (88.6%) had microcysts or gaps in the epithelial cell layers ( Figure 3A). ...

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... shown in Figure 3, all RCE patients showed irregular arrangements of epithelial cells ( Figure 3B), bright reflective deposits in the epithelium ( Figure 3B) and Bowman's layer ( Figure 3C), enlarged basal epithelial cells ( Figure 3B), reduced corneal sub-basal nerves ( Figure 3D), activation of shallow stroma ( Figure 3E), and disorganized stroma fibers ( Figure 3F). Thirty-one patients (88.6%) had microcysts or gaps in the epithelial cell layers ( Figure 3A). ...

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... shown in Figure 3, all RCE patients showed irregular arrangements of epithelial cells ( Figure 3B), bright reflective deposits in the epithelium ( Figure 3B) and Bowman's layer ( Figure 3C), enlarged basal epithelial cells ( Figure 3B), reduced corneal sub-basal nerves ( Figure 3D), activation of shallow stroma ( Figure 3E), and disorganized stroma fibers ( Figure 3F). Thirty-one patients (88.6%) had microcysts or gaps in the epithelial cell layers ( Figure 3A). ...

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... shown in Figure 3, all RCE patients showed irregular arrangements of epithelial cells ( Figure 3B), bright reflective deposits in the epithelium ( Figure 3B) and Bowman's layer ( Figure 3C), enlarged basal epithelial cells ( Figure 3B), reduced corneal sub-basal nerves ( Figure 3D), activation of shallow stroma ( Figure 3E), and disorganized stroma fibers ( Figure 3F). Thirty-one patients (88.6%) had microcysts or gaps in the epithelial cell layers ( Figure 3A). ...

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... shown in Figure 3, all RCE patients showed irregular arrangements of epithelial cells ( Figure 3B), bright reflective deposits in the epithelium ( Figure 3B) and Bowman's layer ( Figure 3C), enlarged basal epithelial cells ( Figure 3B), reduced corneal sub-basal nerves ( Figure 3D), activation of shallow stroma ( Figure 3E), and disorganized stroma fibers ( Figure 3F). Thirty-one patients (88.6%) had microcysts or gaps in the epithelial cell layers ( Figure 3A). ...

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... shown in Figure 3, all RCE patients showed irregular arrangements of epithelial cells ( Figure 3B), bright reflective deposits in the epithelium ( Figure 3B) and Bowman's layer ( Figure 3C), enlarged basal epithelial cells ( Figure 3B), reduced corneal sub-basal nerves ( Figure 3D), activation of shallow stroma ( Figure 3E), and disorganized stroma fibers ( Figure 3F). Thirty-one patients (88.6%) had microcysts or gaps in the epithelial cell layers ( Figure 3A). ...

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... shown in Figure 3, all RCE patients showed irregular arrangements of epithelial cells ( Figure 3B), bright reflective deposits in the epithelium ( Figure 3B) and Bowman's layer ( Figure 3C), enlarged basal epithelial cells ( Figure 3B), reduced corneal sub-basal nerves ( Figure 3D), activation of shallow stroma ( Figure 3E), and disorganized stroma fibers ( Figure 3F). Thirty-one patients (88.6%) had microcysts or gaps in the epithelial cell layers ( Figure 3A). ...

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... shown in Figure 3, all RCE patients showed irregular arrangements of epithelial cells ( Figure 3B), bright reflective deposits in the epithelium ( Figure 3B) and Bowman's layer ( Figure 3C), enlarged basal epithelial cells ( Figure 3B), reduced corneal sub-basal nerves ( Figure 3D), activation of shallow stroma ( Figure 3E), and disorganized stroma fibers ( Figure 3F). Thirty-one patients (88.6%) had microcysts or gaps in the epithelial cell layers ( Figure 3A). ...

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... shown in Figure 3, all RCE patients showed irregular arrangements of epithelial cells ( Figure 3B), bright reflective deposits in the epithelium ( Figure 3B) and Bowman's layer ( Figure 3C), enlarged basal epithelial cells ( Figure 3B), reduced corneal sub-basal nerves ( Figure 3D), activation of shallow stroma ( Figure 3E), and disorganized stroma fibers ( Figure 3F). Thirty-one patients (88.6%) had microcysts or gaps in the epithelial cell layers ( Figure 3A). Twelve patients (34.3%) had infiltrated cells, likely neutrophils, in the mid-stroma ( Figure 3G). ...

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... patients (88.6%) had microcysts or gaps in the epithelial cell layers ( Figure 3A). Twelve patients (34.3%) had infiltrated cells, likely neutrophils, in the mid-stroma ( Figure 3G). Six patients (17.1%) had bright precipitates on the endothelium ( Figure 3H). ...

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... patients (34.3%) had infiltrated cells, likely neutrophils, in the mid-stroma ( Figure 3G). Six patients (17.1%) had bright precipitates on the endothelium ( Figure 3H). After the operation, the epithelium completely healed, the cysts and gaps disappeared, and the bright reflective particles in the epithelium decreased significantly. ...

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... also observed a significant increase in the layer of reflective particles in the corneal epithelium of patients with RCEs ( Figure 3A,B). These highly reflective particles persisted after ablation. ...