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Hyperplastic and hypertrophic sebaceous glands and papillomatous epidermal hyperplasia in the scalp (A: H&E, ×12.5, B: H&E, ×40) and in the left chin (C: H&E, ×12.5, D: H&E, ×40). Several apocrine glands are seen in the mid dermis of the chin (C, D).
Source publication
Nevus sebaceous (NS) is a benign neoplasm occurring mainly on the face and scalp. It commonly occurs as a solitary, well-demarcated lesion. This paper presents a case of multiple nevus sebaceous, which presented as multiple lesions occurring on the temporal scalp and on the contralateral side of the chin. Multiple NS have only rarely been reported.
Context in source publication
Context 1
... within normal limits or negative. Surgical excision with a narrow safety margin was undertaken, and a primary repair with a simple suture technique was used in the scalp and the left chin. Histopathology examination revealed a large number of mature sebaceous glands and overlying papillomatous epidermal hyperplasia, without mature hair follicles (Fig. 2). At present, the patient is in the follow-up ...
Similar publications
A 14-year-old girl presented with a new, rapidly growing, pigmented tumor on a previously existing yellowish, verrucous plaque on the scalp. The patient received complete surgical excision. Routine histology ruled out basal cell carcinoma (BCC) and the histological diagnosis was pigmented trichoblastoma arising in nevus sebaceous (NS). It is import...
Citations
... 8 Nevus sebaceous is rarely reported in the literature to affect the scalp and ipsilateral side of the face. 9 In our case, the scalp and the ipsilateral side of the face were affected. ...
Background Epidermal nevus sebaceous, commonly known as the nevus sebaceous of Jadassohn, is a congenital sebaceous hamartoma. It typically manifests as a single yellowish plaque across the head and neck and is composed of sebaceous glands. It commonly occurs during infancy and grows during puberty. Usually, it follows a benign course; however, in a few cases, it can be malignant. This is the case of a 13-year-old child with verrucous plaques on the temple and scalp. Case report We report the case of a 13-year-old boy with a steadily developing hyperpigmented verrucous plaque on the scalp and ipsilateral side of his face. A dermoscopic examination revealed ridges and fissures in a cerebriform pattern with yellowish-gray globules and a papillary appearance. Physical examination and laboratory tests revealed no abnormalities. Biopsies were taken from the scalp and temple area, and the findings were consistent with the diagnosis of nevus sebaceous. The patient was referred to a plastic surgeon for a staged excision. Conclusions We describe a unique example of a sebaceous nevus that affected the scalp and ipsilateral side of the face. As this hamartomatous growth carries the risk of cancer development, a dermatologist must identify the condition and begin treatment before malignant transformation occurs. This example of multiple verrucous plaques is an exception.
... 4 This condition is most commonly found on the hairy scalp, face, and neck, but rarely presents on the chest and oral mucosa. 5,6 The typical clinical manifestation of NS consists of three stages. 7 At initial stage, the lesion is round, oval, or linear, flat, slightly yellowish, and hairless. ...
Nevus sebaceus (NS) or organoid nevus is an epidermal nevus comprising predominantly sebaceous glands with a prevalence of approximately 0.3% of the newborns. The initial clinical manifestations of NS are single or less commonly multiple yellowish patches with overlying alopecia, usually confined to the scalp. However, it can also appear on the face, preauricular area, and the neck. During puberty, skin lesions will turn into round or linear verrucous plaques accompanied with an increase in number due to the influence of androgens. As they progress, about 20% of the NS cases might turn into secondary tumors which can be benign or malignant (in 2.5% cases). NS can manifest as atypical lesions and may also arise on areas other than its predilection sites. A case of a lesion presented on an atypical location of an 18-year-old male patient treated with carbon dioxide (CO2) laser was reported. Physical examination revealed skin-colored and blackish-brown papules arranged in groups on the left side of the patient’s chest. Histopathological examination on a sample taken from one of the skin lesions on the chest showed hyperkeratosis, acanthosis, papillomatosis, and sebaceous hyperplasia, confirming the diagnosis of NS. The patient was treated with CO2 laser, and clinical improvements were observed. Histopathological examination of NS is not routinely performed; however, it should be carried out when the lesion is atypical and presented at an unusual location, or there is a suspicion of malignancy.
... [5] Further, there are a few case reports of NSJ on face and usually are associated with scalp involvement. [6,7] In this case, we report dermoscopic features of an isolated lesion of nevus sebaceous on face without involvement of scalp, which is quite rare. Furthermore, in our case we also found perifollicular yellowish-brown globules, which may be secondary to follicular plugging. ...
... Around 2/3 rd cases of NS are present at birth and the rest appear in the early infantile period [2] . Clinically the lesions may be single or multiple and are mostly located on the scalp and face but other sites have also been reported [1], [4], [7] . Hair follicles are generally absent over the lesions and sebaceous glands underdeveloped [1] . ...
... Characteristically, the lesion grows proportionally with the size of the patient and then grows more rapidly, becomes more thickened and protuberant, and at times acquires a verrucous or even a nodular appearance [1], [2] . Nevus sebaceous is usually solitary, although multiple and widespread lesions have been reported [4] . A new phenotype, known as cerebriform nevus sebaceous was first described by Ramesh et al. in 1998, when they described a 20-year-old man with a large cerebri-form plaque over the right parietooccipital region, which was confirmed by histopathological examination [5] . ...
... Cerebriform nevus sebaceous is characterized by large, pedunculated or verrucous, pink, hairless, nodules or tumors in newborn infants [5], [6] . Nevus sebaceous is usually an isolated finding but it may sometimes be associated with syndromes like SCALP syndrome (sebaceous nevus, central nervous system malformation, aplasia cutis congenita, limbal dermoid, and pigmented nevus) and linear sebaceous nevus syndrome (Schimmelpenning syndrome) characterized by extensive nevus sebaceous distributed along Blaschko's lines, central nervous system abnormalities, epilepsy, mental retardation, ocular abnormalities, musculoskeletal defects, cardiovascular abnormalities, and urologic abnormalities [4], [7] . Large or extensive lesions may be associated with developmental deficits [4] . ...
... O nevo sebáceo, também conhecido como nevo organóide, é um hamartoma congênito descrito em 1895 por Jadassohn, e denominado como nevo sebáceo de Jadassohn por Robinson em 1932. 1 Ocorre em cerca de 0,3% dos recém-nascidos, apresentando alterações proliferativas das glândulas sebáceas, sudoríparas e folículos pilosos. Geralmente se apresenta como lesão circunscrita, de tonalidade amarelo-alaranjada com pequenas dimensões, no couro cabeludo e face. ...
... [1] Clinically, it presents as a single or, less commonly, multiple yellowish-colored plaques with overlying alopecia, usually confined on the scalp; however, it can also appear on the face, preauricular area, and neck region. [2,3] Here, we reported a case of NS in a discrete linear pattern located on the left chest region, in contrast with typical cases, to assist physicians in the early diagnosis of this condition and to prevent unnecessary examinations and inadequate therapeutic interventions. ...
... Classically, it presents at infancy as a single bald patch over the scalp and generally remains unchanged until puberty after which the patch becomes more thickened and protuberant and at times verrucous or nodular, with a smooth velvety surface. [1] Among 202 cases of Chi et al., [2] the most common site of NS was the scalp (66.8%), followed by the face (26.7%) and the neck (5.5%). However, NS may also be present at other sites, such as the trunk or mucosae, [3][4][5] or have an atypical morphology. ...
... Clinically, it appears as a yellowish verrucous plaque usually on the scalp or forehead. It may appear at birth or develop during childhood as smooth, yellowish, hairless patches, and change into elevated verrucous plaque during puberty 10,11 . On histopathology, the epidermis shows acanthosis and papillomatosis, and sebaceous gland hyperplasia; immature hair follicles are observed in the dermis 12 . ...
Folliculocystic and collagen hamartoma is a newly described complex hamartoma characterized by abundant collagen deposition, concentric perifollicular fibrosis, and keratin- filled infundibular cysts that are visible on histopathological examination. Here, we report the case of a 19-year-old Korean man who had large brownish infiltrated plaques with numerous follicular comedo-like openings and subcutaneous cystic masses on his right temporal scalp and ear since birth. Histopathological examination showed abundant collagen deposition in the dermis that extended up to the subcutaneous fat layer, multifocal infundibular cysts packed with keratin, and perifollicular inflammation and fibrosis. Hence, we describe a new type of hamartoma with folliculocystic and collagen components but without tuberous sclerosis.
... The most common site is scalp (66.8%), followed by face (26.7%) and neck (5.5%). 5 The female child had pigmented lesions, however, pigmentation is not commonly reported in nevus sebaceous lesions. ...
Linear Nevus Sebaceous Syndrome (LNSS) is a rare sporadic oculoneurocutaneous disorder, also classified as Organoid Nevus Syndrome. It consists of a triad of midline facial linear nevus sebaceous, central nervous system and ocular abnormalities. To the best of authors’ knowledge ophthalmic features of LNSS have never been reported in Pakistani population. We report two cases of LNSS, associated with multiple cutaneous nevus sebaceous lesions, complex ocular choristomas and rare bilateral presentation in one patient. Ocular choristomas included limbal dermoids, dermolipomas at superior fornices and chroidal choristoma. Ocular surface was successfully reconstructed by excision of limbal dermoids, partial keratectomy and amniotic membrane transplant.
Background
Epidermal nevus sebaceous, commonly known as the nevus sebaceous of Jadassohn, is a congenital sebaceous hamartoma. It typically manifests as a single yellowish plaque across the head and neck and is composed of sebaceous glands. It commonly occurs during infancy and grows during puberty. Usually, it follows a benign course; however, in a few cases, it can be malignant. This is the case of a 13-year-old child with verrucous plaques on the temple and scalp.
Case report
We report the case of a 13-year-old boy with a steadily developing hyperpigmented verrucous plaque on the scalp and ipsilateral side of his face. A dermoscopic examination revealed ridges and fissures in a cerebriform pattern with yellowish-gray globules and a papillary appearance. Physical examination and laboratory tests revealed no abnormalities. Biopsies were taken from the scalp and temple area, and the findings were consistent with the diagnosis of nevus sebaceous. The patient was referred to a plastic surgeon for a staged excision.
Conclusions
We describe a unique example of a sebaceous nevus that affected the scalp and ipsilateral side of the face. As this hamartomatous growth carries the risk of cancer development, a dermatologist must identify the condition and begin treatment before malignant transformation occurs. This example of multiple verrucous plaques is an exception.
