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Histopathology of spleen of mice of Group I –Normal Control showing normal red and white pulp areas in the splenic parenchyma. (H&E x 40X) WP= White Pulp, RP= Red Pulp.
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... Different parts of the plant have been associated with various physiological properties. Some studies have been carried out exclusively on the leaves [6][7][8][9], stem + leaves [10,11], aerial parts [12,13] and whole plant [14,15] to establish their physiological effects; but to the best of our knowledge, none was done solely on the stem. The study was therefore designed to investigate the effect of oral administration of chloroform stem extract of Portulaca oleracea (CSEPO) on haematological and biochemical parameters in male wistar rats. ...
Portulaca oleracea Linn. has a history of extensive use as a medicinal plant and is a component of the Nigerian ethnomedical pharmacopoeia. Although several studies have been carried out exclusively on the leaves to ascertain the physiological effect, there seems to be dearth of literature on the physiological effect of the stem. This study which was designed to fill this gap investigated the sub-chronic effect of oral administration of chloroform stem extract of P.oleracea (CSEPO) on haematological parameters and plasma activities of some enzymes (Alanine Aminotransferase - ALT, Alkaline Phosphatase - ALP & Aspartate Aminotransferase - AST) and levels of other biochemical parameters such as total protein, albumin, bilirubin, urea and creatinine in male wistar rats. Twenty animals were randomly divided into 4 groups of 5 rats each. Group A(Control) received 0.5 ml of olive oil(vehicle) while Groups B, C & D received 125, 250 & 500 mg/kg body weight of CSEPO respectively for 21 days by oral gavage. At the end, the animals were anaesthetized and blood samples were collected for haematology and plasma biochemical assay. No significant (P > .05) variation occurred in the mean values of ALT, ALP, AST, total protein, albumin, bilirubin, urea, creatinine, Packed Cell Volume (PCV), haemoglobin concentration, RBC, WBC and differential leucocyte counts relative to the control. There was a highly significant (P < .01) increase in the total platelet count only at the dose of 500mg/kg in comparison with control. Oral administration of CSEPO as used in this study had no adverse effect on haematological and biochemical parameters. Secondly, CSEPO may be a useful remedy in thrombocytopenia, due to its potential to increase platelet count. However, further study is recommended in that regards.
... It is known as 'Ntioke', or 'Idiridi' in Igbo; 'Esan omode' or 'Papasan' in Yoruba; 'Babbajibji' or 'Halshen saniya' in Hausa and 'Eferemakara' in Efik 4,5 The use of Portulaca oleracea in folk medicine dates back to ancient times and has been given the name, 'Global Panacea' by the World Health Organization (WHO). 6 All parts of the plant, especially the leaves and stems, are useful as remedies for many ailments and they are usually used in fresh or dried state. In Nigeria, the plant is used by traditional medicine practitioners in the management of infertility in women where about 500 ml of the decoction or juice is usually administered twice daily for a minimum period of two weeks. ...
Background and aim: Decoctions and infusions from the aerial parts of Portulaca oleracea Linn., especially
the leaves and stems, are used by traditional medicine practitioners in Nigeria to enhance fertility in
humans. The scarcity of literature on the use of this plant for the said purpose as well as its efficacy
prompted this research. Study investigated effect of lipophilic and hydrophilic leaf extracts of Portulaca
oleracea on oestrous cycle, female sex hormones at various phases of oestrous cycle and ovarian and
uterine histomorphology in albino rats.
Experimental procedure: Experimental animals were randomly divided into 7 groups of 5 rats each.
Group A (control) received 0.5 ml 20% Tween 80 (vehicle), groups B, C & D received 125, 250 & 500 mg/kg
of the lipophilic extract respectively and E, F & G received 125, 250 & 500 mg/kg of the hydrophilic
extract respectively for 21 days. Oestrous cycle was assessed daily. At the end, blood samples (for hormones)
and ovarian &uterine sections (histoarchitecture) were collected.
Results and conclusion: Both extracts had no significant (p > 0.05) effect on oestrous cycle, ovarian &
uterine histoarchitecture and female sex hormones except at proestrus phase where significant (p < 0.05)
decrease in LH and FSH was recorded. P.oleracea as used in this study may have deleterious effect on
female reproductive system as shown by the disruption of the hormones at proestrus phase. This can
form a basis to refute the use of P.oleracea leaf extracts in enhancing fertility as it has been shown to
affect the gonadotropins involved in folliculogenesis.
... The use of Portulaca oleracea in folk medicine dates back to ancient times. It has been listed by the World Health Organization (WHO) as one of the most commonly used medicinal plants, which has given it the name, 'Global Panacea' [6]. All parts of the plant, especially the leaves and stems, are useful as remedies for many ailments and they are usually used in fresh or dried state. ...
Although the use of medicinal plants is becoming popular globally, some of these plants which are purported to be safe are not without side effects or toxicity. Portulaca oleracea, Linn. is among the medicinal plants used globally in the treatment of diseases and management of health challenges. The dearth of information on the toxicity of Portulaca oleracea in a long term use prompted this study which investigated the sub-chronic effect of the oral administration of polar (aqueous methanol) leaf extracts of Portulaca oleracea on haematological parameters in male albino rats. Sixty-four animals were randomly divided into 4 groups of 16 rats each. Group 1(Control) received 0.5 ml of 20% Tween 80 (vehicle), Groups 2, 3 & 4 received 125, 250 & 500 mg/kg bw of the extract respectively for 60 days by oral gavage. On days 14, 28, 42 and 60; four rats from each group were anaesthetized and blood samples were collected for haematology. No significant (p>0.05) variation occurred in the mean values of PCV, hemoglobin concentration, RBC count, platelet count and differential leucocyte count relative to the control throughout the 60-day duration. Significant (p<0.05) increase in WBC count was recorded on day 42 in the 500mg treated group. Oral administration of polar leaf extract of P.oleracea as used in this study had no injurious effect on haematological parameters in a long term treatment of 60 days; thus can be said to be non-toxic to blood parameters.
... The use of P. oleracea in folk medicine dates back to ancient times and has been given the name, "Global Panacea" by the World Health Organization [6]. The Chinese legend calls it "vegetable for long life," as it has been used in their traditional medicine for many generations [2]. ...
Objectives: To supply scientific information/literature on the use of Portulaca oleracea in enhancing fertility in males; either to validate or to refute this folkloric use. This study investigated the effect of the lipophilic and hydrophilic leaf extracts of P. oleracea on male reproductive parameters. Methods: The extracts were obtained using two extracting solvents-chloroform and 80% aqueous methanol in succession. Experimental animals were randomly divided into seven groups of 16 rats each. Group A (control) received 0.5 ml 20% Tween 80 (vehicle), groups B, C, and D received 125, 250, and 500 mg/kg of the lipophilic extract, respectively, and groups E, F, and G received 125, 250, and 500 mg/kg of the hydrophilic extract, respectively, for 60 days. On days 14, 28, 42, and 60, four rats from each group were weighed and anesthetized for sample collection. Blood (for testosterone), testes (weight and histomorphology), and sperm cells from caudal epididymis (for semen analysis) were collected. Results: Both extracts had no significant (p > 0.05) effect on testicular weight and histo-morphology, and sperm cell characteristics but caused a significant (p < 0.05) increase in sperm count. Only the hydrophilic extract produced a significant (p < 0.05) reduction in the testosterone level. Conclusion: Leaf extracts of P. oleracea as used in this study improved spermatogenesis irrespective of the decline in testosterone level. This may justify the use of P. oleracea leaf extracts in enhancing fertility in males, although further studies are required to elucidate the mechanism and compounds associated with these properties.
... Acute toxicity evaluation gives the information about LD50. Both subacute and chronic evaluations give information about the cumulative toxicity at low dose on prolonged period of time 11 . With this view, in the present study, the extract was subjected to a toxicity study. ...
The village of Bhagabanbasan is in the Paschim Midnapore district of West Bengal, India. Indigenous people of
this area are observed to consume some plants and herbs with high medicinal values in their daily diet. Those
plants and herbs with exclusive medicinal properties have been used in folk medicine from long time. In this mini
review, we have provided a brief account of five such edible herbs and plants from Bhagabanbasan village of West
Midnapore. A compact knowledge is necessary for conservation of those plants. Our present study also highlights
the immense possibility of sustainable folk medicinal practice in heath and diseases. This study also unfurls a world
of possibility to develop minimal or nil side effect bearing potential drugs from plants of this particular
geographical region.
