Fig 2 - available via license: Creative Commons Attribution-NonCommercial 4.0 International
Content may be subject to copyright.
Histopathology of scarring alopecia under immune checkpoint blockade. (a) Vertical sections of a scalp punch biopsy of case 2 show dense lichenoid interface dermatitis around the infundibulum and isthmus of the hair follicle (Haematoxylin and eosin (H&E) stain ×50). (b) The asterisk marks the lymphocytic infiltrate damaging the hair follicle epithelium (long arrow). Short arrow marks the perifollicular fibrosis (H&E stain ×200).
Source publication
is missing (Short communication)
Similar publications
A Alopecia Areata (AA) é uma patologia que afeta a unidade folicular e as alterações ungueais concomitantemente ao quadro, de causa indefinida e multifatorial e evidentes manifestações autoimunes e genéticas. Portanto, objetiva-se avaliar o uso dos corticoides no tratamento da Alopecia Arreata. Trata-se de uma revisão metódica de literatura, teve c...
Background and Rationale
Cicatricial alopecia not only affects patients' appearance but also has negative effects on their physical and mental well‐being, as well as their daily lives. Therefore, it is essential to provide proactive treatment to patients.
Objective
To explore the clinical effects of autologous follicular unit extraction (FUE) tran...
Background The scar alopecia after cranioplasty (SAC) may decrease the patient's quality of life. We have treated SAC using follicular unit extraction (FUE). The aim of this study was to discuss that efficacy of FUE and how much hair follicular unit (FU) should be transplanted intraoperatively for the treatment of SAC.
Methods We treated 10 patient...
Background
Conflicting results have emerged in studies conducted to reveal the relationship between alopecia areata (AA) and depression and anxiety. The comorbidity of depression and anxiety in patients with patchy AA who applied to a tertiary care center will be investigated and compared with a healthy control group.
Methods
This study included 8...
Citations
This article discusses drug-induced hair loss, which can occur with many drugs including cytotoxic agents, biologics, and immunomodulating agents, among others. It outlines the diagnosis and management of drug-induced alopecia, with a focus on recently implicated drugs.
Immune checkpoint inhibitors (ICIs) represent an emerging treatment option for a variety of cancer types. Through inhibition of programmed cell death protein 1 (PD-1), programmed cell death ligand 1 (PD-L1), and/or cytotoxic lymphocyte-associated antigen-4 (CTLA-4), ICIs activate the host's immune system causing a heightened anti-tumor response. However, off-target effects of ICIs can result in numerous different immune-related cutaneous adverse events (irCAEs). Beyond impacting quality of life, irCAEs can lead to dose limitations or discontinuation of anti-cancer therapies. Correct diagnosis is necessary for expedient and appropriate management. Skin biopsies are often performed to increase diagnostic accuracy and guide clinical management. An extensive literature review was performed using the PubMed database to identify the reported clinical and histopathologic features of irCAEs. This comprehensive review primarily details the histopathologic features of various irCAEs reported to date. Clinical presentation and immunopathogenesis are also discussed in relation to histopathology.
