Histopathology of pseudocarcinomatous hyperplasia. (a) Epidermal hyperplasia and elongation of the rete ridges were observed. (b) No atypia was noted in the elongated rete ridges. (c) Invasion of inflammatory cells was recognized around the skin-stapled site. (d) Two years after the last operation. 

Contexts in source publication

Context 1

... epidermal hyperplasia, elongation of the rete ridges, and invasion of inflammatory cells (Figs 4a-4c), features characteristic of pseudocarcinomatous hyperpla- sia, were observed. Thus, the lesion was diagnosed as VSLDN on the basis of histological findings, the anamnestic diabetic neuropathy, and the easily weight-bearing protruded lo- cation. As VSLDN is a benign disease and additional resection was not needed, skin from ePlasty VOLUME 15 the groin region was grafted onto the skin defect. Figure 4d shows the status of the foot 6 years after the last operation. No recurrence has been observed to date. ...

Context 2

... epidermal hyperplasia, elongation of the rete ridges, and invasion of inflammatory cells (Figs 4a-4c), features characteristic of pseudocarcinomatous hyperpla- sia, were observed. Thus, the lesion was diagnosed as VSLDN on the basis of histological findings, the anamnestic diabetic neuropathy, and the easily weight-bearing protruded lo- cation. As VSLDN is a benign disease and additional resection was not needed, skin from ePlasty VOLUME 15 the groin region was grafted onto the skin defect. Figure 4d shows the status of the foot 6 years after the last operation. No recurrence has been observed to date. ...

Context 3

... contrast, in our case, VSLDN occurred in a non-weight-bearing region, directly on top of residual skin staples. We hypothesize that the moderate infiltration of inflam- matory cells around the skin-stapled site was associated with the formation of the slightly projected nodule and that this nodule promoted the formation of VSLDN through chronic mechanical stimulation, similar to callus formation. Indeed, the moderate infiltration of inflammatory cells around the skin-stapled site was recognized histologically (Fig 4c), and the inflammation exacerbated the fragility of the condition against chronic pressure and friction. For gas gangrene, several incisions, as well as debridement, are urgently performed as lifesaving measures. After control of the infection, mesh skin grafting is often performed on the ulcer, as it is frequently extensive, and a stapler is used for the fixation of the graft. The use of skin staples is convenient and is associated with a reduced operative time. On the contrary, if the staples are left for a prolonged period, as in the present case, they can become buried inside the granulation and are difficult to remove. Thus, particularly on the feet, it is necessary to remove the staples carefully in order to avoid skin lesions such as VSLDN from developing, even in cases when the treated part is not a weight-bearing ...