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Histopathology of lungs and livers from intratracheally infected mice submitted to the immunization with LevRad associated or not with fluconazole. The extension and distribution of granulomas as well as the fungal burden were observed 60 and 120 days after infection (30 and 90 days after initiating treatment). (A) intense coalescent multifocal interstitial granulomatous pneumonia (HE, 40X magnification); (B) (C) intra and extracellular fungal structures with birefringent membrane characteristic of P. brasiliensis (HE, 400X magnification); (D) mild to moderate multifocal granulomas surrounded by fibrous connective tissue constituted (HE, 100X magnification); (E) discrete focal granulomatous lesion (HE, 40X magnification); (F) lung free from board fungi, inflammatory infiltrated and granulomatous lesion (HE, 40X magnification); (G) well organized discrete focal granulomatous lesions (HE, 40X magnification); (H) fungal structures inside the granulomas (HE, 400X magnification).
Source publication
Paracoccidioides brasiliensis is the agent of paracoccidioidomycosis (PCM), the most prevalent deep mycosis in Latin America. The treatment varies according to the chemotherapeutic drug and the disease severity, and the lack of it can results in high frequency of relapse and sequels. Thus, the search for new therapeutic alternatives is necessary. T...
Contexts in source publication
Context 1
... the histopathological analysis confirmed these results. After 60 days, the lungs of infected animals (C+) presented extensive tissue destruction with development of intense coalescent multifocal interstitial granulomatous pneumonia ( Figure 3A). Neutrophilic linfohistiocytic infiltrate associated with giant cells was observed. ...
Context 2
... was a large number of intra and extracellular fungal structures with birefringent membrane. Such morphologic feature is characteristic of P. brasiliensis ( Figure 3B and 3C). The liver showed mild to moderate multifocal granulomas surrounded by fibrous connective tissue constituted by lymphocytes and fungal cells inside ( Figure 3D). ...
Context 3
... morphologic feature is characteristic of P. brasiliensis ( Figure 3B and 3C). The liver showed mild to moderate multifocal granulomas surrounded by fibrous connective tissue constituted by lymphocytes and fungal cells inside ( Figure 3D). There was no histhopatological alteration in the spleen (data not shown). ...
Context 4
... discrete focal granulomatous lesion was observed in the lung. This lesion was formed by linfohistiocytic infiltrate with giant cells and a few numbers of viable fungal cells (Figure 3E). At the same time, the lung obtained from the InRadMed group did not present yeast cells, inflammatory infiltrated or granulomatous lesion ( Figure 3F). ...
Context 5
... lesion was formed by linfohistiocytic infiltrate with giant cells and a few numbers of viable fungal cells (Figure 3E). At the same time, the lung obtained from the InRadMed group did not present yeast cells, inflammatory infiltrated or granulomatous lesion ( Figure 3F). These results were compared with the results obtained from the uninfected mice (C-). ...
Context 6
... results were compared with the results obtained from the uninfected mice (C-). However, the lungs obtained from the InRad and InMed group (analyzed 60 days after infection) presented well organized discrete focal granulomatous lesions with low counting of yeast cells ( Figure 3G and 3H). No significant injury was observed in the liver and spleen after 60 days of infection. ...
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Paracoccidioides brasiliensis is the agent of paracoccidioidomycosis (PCM), a cause of disease in healthy and immunocompromised persons in Latin America. The infection begins after inhalation of the fungal propagules and their thermo-dimorphic shift to yeast form. The development of the disease depends on factors associated with the host immune res...
