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Histopathology from the trunk showing flattened epidermis, slightly thickened papillary dermis, with numerous melanophages on hematoxylin and eosin stain (×10)
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... Histopathological examination shows sparse superficial perivascular lymphocytic infiltrate with melanophages within papillary dermis. 4 Hemochromatosis is a disorder in which iron overload leads to deposition of iron in organs such as skin and liver. Cutaneous pigmentation is diffuse and bronze colored. ...
The category of generalized and localized genetic hyperpigmentation has a diversity of manifestations. This chapter presents with familial progressive hyperpigmentation, familial gigantic melanocytosis, acquired universal melanosis, xeroderma pigmentosum, ichthyosis vulgaris, ichthyosis bullosa of siemens, bullous congenital ichthyosiform erythroderma, pointillist melanotic macules, Fanconi anemia, adrenoleukodystrophy, incontinentia pigmenti, incontinentia pigmenti in the proband father and his daughter, incontinentia pigmenti with cornoid lamella, phylloid hypermelanosis, periorbital hyperpigmentation, acrogeria, dyskeratosis congenita, transient neonatal pustular melanosis, and freckles.
