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![Histopathologicalanalysis of empty bone lacunae in the femoral head in the 4th (A-F) week and the 8th (G-L) week in the control group [(A) (100X), (D) (200X); (G) (100X), and (J) (200X)], DA group [(B) (100X), (E) (200X); (H) (100X), and (K) (200X)] and DAA group [(C) (100X), (F) (200X), (I) (100X), and (L) (200X)]. Empty bone lacunae (the red arrow) and trabecular fractures (the yellow arrow) were evident in the femoral heads of the three groups, demonstrating that the mouse model of femoral head osteonecrosis was successfully established.](publication/363387564/figure/fig4/AS:11431281083608275@1662688220709/Histopathologicalanalysis-of-empty-bone-lacunae-in-the-femoral-head-in-the-4th-A-F-week.png)
Histopathologicalanalysis of empty bone lacunae in the femoral head in the 4th (A-F) week and the 8th (G-L) week in the control group [(A) (100X), (D) (200X); (G) (100X), and (J) (200X)], DA group [(B) (100X), (E) (200X); (H) (100X), and (K) (200X)] and DAA group [(C) (100X), (F) (200X), (I) (100X), and (L) (200X)]. Empty bone lacunae (the red arrow) and trabecular fractures (the yellow arrow) were evident in the femoral heads of the three groups, demonstrating that the mouse model of femoral head osteonecrosis was successfully established.
Source publication
Background: To study the pathogenesis of steroid-induced femoral head osteonecrosis, an ideal animal model is very important. As experimental animals, mice are beneficial for studying the pathogenesis of disease. However, there are currently few mouse models of steroid-induced femoral head osteonecrosis, and there are many questions that require fu...
Context in source publication
Context 1
... of DAA on the number of blood vessels in the femoral head Confirmation of the establishment of a femoral head osteonecrosis model based on the rates of osteonecrosis and mortality in mice DAA increased the rate of femoral head osteonecrosis in mice. As shown in Figure 4, the H&E staining results showed that more than three empty lacunae appeared in the femoral head region in the DA and DAA groups, and trabecular fractures were visible. These data demonstrate that the mouse model of femoral head osteonecrosis was successfully established ( Theoleyre et al., 2004;Qin et al., 2006;Boyce and Xing, 2008;Okazaki et al., 2009;Singh et al., 2012;Dinh et al., 2017). ...
