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The importance of early diagnosis and treatment of oral squamous cell carcinoma in insuring an optimum patientoutcome is emphasized by comparing and contrasting the clinical presentation, diagnosis, treatment and follow-up oftwo patients who presented initially with fairly equivalent mucosal lesions but followed different treatment paths. Thediverg...
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... [18] Considering the asymptomatic nature of oral cancer at its early stage, early detection of OSCC plays a critical role in prognosis and reduces treatment-related morbidity and mortality. [4] Recent attention has focused on the potential application of biomarkers for patient assessment in multiple clinical stages. Cancer biomarkers can be used to estimate the risk of cancer, screen for occult primary cancers, distinguish benign from malignant tumors, diagnose cancer, develop a prognosis, detect recurrence, and assess response to therapy. ...
OBJECTIVE MicroRNAs (miRs) are small, non-coding RNAs that are involved in tumor development and progression in multiple cancers with the action as oncomiRs or tumor suppressor miRs. Therefore, miRNAs have become potential biomarkers in the diagnosis and treatment of cancer. The previous studies have revealed that miR7111-5p and miR6870-5p are abnormally expressed in various types of cancer but in oral squamous cell carcinoma (OSCC) has not been elucidated. The main objective of our study was to evaluate the expression alternations of miR7111-5p and miR6870-5p as well as serum response factor (SRF) in OSCC tissues compared with adjacent normal oral epithelial tissues. METHODS SRF was identified as a potential target gene of miR7111-5p and miR6870-5p using the TargetScan, Mirwalk, and Mirdb miRNA-target prediction tools. SRF, miR7111-5p, and miR6870-5p expression levels were examined by RT-qPCR in OSCC compared with normal tissues. RESULTS Our results showed that miR7111-5p and miR6870-5p were significantly downregulated in 30 pairs of OSCC tissue samples (p<0.05) relative to adjacent normal oral tissues. In the present study, we found that the high expression level of SRF was negatively correlated with the down regulation of miR7111-5p and miR6870-5p and was statistically correlated with the tumor stage. CONCLUSION miR7111-5p, miR6870-5p, and SRF may be potential prognostic biomarkers for OSCC diagnosis and monitoring.
... Squamous cell carcinoma can be classified into numerous types of cancer resulting from squamous cells, which are epithelial tissues lining the cavities and surfaces of blood vessels and organs throughout the body. Early detection accompanied with appropriate treatment is crucial [1]. Cell carcinoma is considered one of the most common types of skin cancer. ...
The objective of this study was to evaluate the effectiveness of optical Doppler tomography (ODT) using a portable handheld-type probe for investigating the blood flow in blood vessels of cell carcinoma-affected small animal models. To perform in vivo and real-time investigation, we developed a spectral domain-optical Doppler tomography (SD-ODT) system equipped with a portable handheld-type scanning probe, which uses the Kasai autocorrelation algorithm for Doppler imaging. The system capabilities were evaluated by conducting preliminary experiments on flow measurement in a microtube. The study was performed on healthy and squamous cell carcinoma-affected mouse specimens. The results demonstrate the possibilities and advantages of employing an SD-ODT system with handheld-type scanning probe for cell carcinoma investigation in small animal models.
... Numerosas publicaciones reportan la coexistencia del síndrome de Gorlin-Goltz con diferentes tumores, lo que sugiere que un paciente con este síndrome tiene potencial para desarrollar no solo CBC basales sino también otros carcinomas y tumores, ya que la mutación en el PTCH-1 afecta todos los tejidos (11,14). Cada paciente debe ser valorado y analizado de manera estricta durante el examen clínico odontológico. ...
RESUMEN. Antecedentes: El síndrome de Gorlin-Goltz, o síndrome nevoide de células basales (SNCB), es un trastorno autosómico dominante de baja incidencia. Su etiología está relacionada con una mutación en el gen PTCH y afecta los sistemas esquelético, oftalmológico y neurológico. Su prevalencia es de 1:60.000 y las mutaciones de novo se presentan aproximadamente en un 20 % a 30 % de los casos. Objetivo: Describir el proceso diagnóstico y manejo de un caso de esporádica presentación de una paciente con SNCB con carcinoma escamocelular (CEC) en labio superior. Descripción del caso: Se trató de una paciente de 58 años, quien asistió a consulta odontológica por motivos estéticos y funcionales. Se encontró un CEC (confirmado por inmunohistoquímica) asintomático delimitado en el lado izquierdo del labio superior, con erosiones de color rojizo y costra. No se encontraron linfoadenopatías asociadas. También presentó fisuras palmoplantares y múltiples carcinomas basocelulares en la espalda y el dorso de la mano izquierda (con antecedentes familiares similares). Radiográficamente, no se observaron queratoquistes mandibulares que usualmente se asocian con el síndrome de Gorlin-Goltz. Conclusiones: La paciente fue diagnosticada con SNCB, pues presentaba dos criterios mayores (dos o más CBC y piqueteado palmoplantar) y dos menores (calcificación laminar de la hoz del cerebro y antecedente de fibromas ováricos). El tratamiento odontológico se planeó y se remitió a la paciente a la institución pertinente para manejar su condición sistémica.ABSTRACT. Background: Gorlin-Goltz syndrome, or basal cell nevus syndrome (BCNS), is a rare autosomal dominant disorder caused by mutations in the Patched (PTCH) gene. BCNS affects about 1:60,000 people and de novo mutations represent approximately 20 % to 30 % of all cases. Purpose: To describe the diagnostic process and management of a rare case of a female patient with BCNS and squamous cell carcinoma (SCC) in upper lip. Case description: The patient was a 58-year-old woman who attended the dental office seeking aesthetic and functional treatment. An asymptomatic, delimited SCC with red erosions and scab in left upper lip was diagnosed (confirmed through immunohistochemistry). Associated lymph adenopathy was not observed. The patient also presented palmoplantar pits and multiple basal cell carcinomas (BCC) in back and left-hand back (and similar family history). X-rays did not show mandible keratocysts often associated to the Gorlin-Goltz syndrome. Conclusions: The patient was diagnosed with BCNS because she met two major (two or more BCCs and palmoplantar pits) and two minor criteria (lamellar calcification of brain sickle and history of ovary fibromas). Dental treatment was planned and the patient was referred to another institution to address her systemic condition.
