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Common features of arthritis include destruction of extracellular matrices in cartilage and bone as a result of chronic inflammation. Cartilage deterioration is generally described as a result from the effect of immune cells and their inflammatory mediators. However, recent reports suggest a role of chondrocytes in the initiation of inflammation in...
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... the synovial fluid. Nutrition and waits disposal has to be transported by diffusion through the synovial fluid due to the absence of blood vessels and lymphatic-drainage in the cartilage. The cells present in the cartilage are chondrocytes, and are contained in cavities in the matrix called "lacunae", representing 1-5 % of the hyaline cartilage (Fig. 2). Chondrocytes synthesize and secrete macromolecules that constitute the cartilage ...
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