Histological findings of the adrenal cyst (HE stain). a) Case 3. A multilocular cyst is found in the adrenal cortex. The cyst is lined with cuboidal to flat epithelial cells and contains eosinophilic hyalinized materials. Scale bar = 200 µm. b) Case 7. Small ducts with cuboidal epithelia (arrows) adjacent to a cyst (asterisk). Scale bar = 50 µm. c) Case 10. The luminal surface of the cyst lacks epithelial lining, and a loose connective tissue is observed on the luminal surface (arrowheads). Adrenal cortical cells are observed beneath the connective tissue (asterisk). Scale bar = 200 µm. d) Case 10. A dilated lymphatic vessel (asterisk) is found around the cyst. Scale bar = 200 µm.

Histological findings of the adrenal cyst (HE stain). a) Case 3. A multilocular cyst is found in the adrenal cortex. The cyst is lined with cuboidal to flat epithelial cells and contains eosinophilic hyalinized materials. Scale bar = 200 µm. b) Case 7. Small ducts with cuboidal epithelia (arrows) adjacent to a cyst (asterisk). Scale bar = 50 µm. c) Case 10. The luminal surface of the cyst lacks epithelial lining, and a loose connective tissue is observed on the luminal surface (arrowheads). Adrenal cortical cells are observed beneath the connective tissue (asterisk). Scale bar = 200 µm. d) Case 10. A dilated lymphatic vessel (asterisk) is found around the cyst. Scale bar = 200 µm.

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Adrenal disorders are common in ferrets, but there are few studies on cystic lesions of the adrenal gland. The present study describes pathological and immunohistochemical features of adrenal cysts in eleven ferrets and discusses their histogenesis. In nine of eleven cases examined, which included seven, one, and one right, left, and bilateral case...