Figure - available from: Frontiers in Oncology
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Histological features of the resected tumors. Representative pathological photos of the third surgery: (A) original magnification × 100 and insert × 400. Representative photos of the latest surgery: (B) original magnification × 100 and insert × 400.
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Backgroud: Presacral tumors are rare space occupying lesions that arise in the presacral space. The incidence of presacral tumor has been reported to be 1 in 40,000 to 63,000 patients. An even rarer occurrence is the transformation of a presacral tumor into a squamous cell carcinoma (SCC).
Case Summary: A 61 years old man was referred to our hospit...
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Citations
... Most cases are asymptomatic and are incidentally identified by CT or MRI [4]. Surgical resection is recommended since the tumor is associated with infection and has malignant potential, such as squamous cell carcinoma arising from a presacral epidermoid cyst [3,4,7]. ...
Background
Complete resection of presacral epidermoid cysts is recommended due to the potential for infection or malignancy. Transsacral and transabdominal approaches have been used to treat presacral tumors. However, there are no standard surgical approaches to resection. We present the case of a presacral epidermoid cyst in an obese male patient who underwent laparoscopic transabdominal resection.
Case presentation
A 44-year-old man was referred to our hospital for treatment of a cystic tumor on the pelvic floor. Contrast-enhanced computed tomography revealed a 45 × 40-mm tumor on the left ventral side of the rectum, right side of the ischial spine, dorsal side of the seminal vesicles, and in front of the 5th sacrum. Enhanced magnetic resonance imaging revealed a multilocular cystic tumor with high and low signal intensities on T2-weighted images. The tumor was diagnosed as an epidermoid cyst. We considered the transsacral or laparoscopic approach and decided to perform a laparoscopic-assisted transabdominal resection since the tumor was in front of away from the sacrum, and a transsacral approach would result in a larger scar due to poor visibility from the thickness of the buttocks. The entire tumor was safely resected under laparoscopic guidance, because the laparoscopic transabdominal approach can provide a good and magnified field of view even in a narrow pelvic cavity with small skin incisions, allowing safe resection of the pelvic organs, vessels, and nerves while observing the tumor contour.
Conclusions
The laparoscopic transabdominal approach is an effective method for treating presacral tumors in obese patients.
... The evidence of anterior sacral meningocele was insu cient. Although it is extremely rare, benign cysts can also transform into malignant tumors (22). In our case, a well-de ned smooth margin with the absence of invasion may help to differentiate it from malignant masses. ...
Introduction: Perirectal epidermoid cyst is a rare mass arising from the ectodermal germ cell layer of the hind gut, which is most often found in middle-aged women. It is difficult for us to make an accurate diagnosis and distinguish from other developmental cysts.
Case Presentation: Here, we report a 19-year-old girl who had suffered from sacrococcygeal falls and burns on the left buttocks in the growth experience. There was a scar on the left buttocks, and a soft mass with sacral deformity was seen in the sacrococcygeal region. According to the results of the sacrococcygeal CT and pelvic MRI, the preoperative diagnosis included presacral epidermoid cyst, anal sinus and sacrococcygeal scoliosis. Finally, the cyst was completely resected posteriorly through sacrococcygeal approach. Pathology was verified as an epidermoid cyst. The patient stayed recurrence-free after six months of follow up.
Conclusion: Perirectal epidermoid cyst is a rare mass that should be considered in the differential diagnosis of pararectal cysts. It is of significant for the approach of surgery and prognosis.
... Once infected, pelvic cysts are very difficult to manage surgically. Instead of undergoing biopsy, rare cases of malignant degeneration of an inclusion cyst can be identified on imaging as a focus of irregular wall-thickening on the cyst on imaging [3,12,13]. ...
... Generally, non-infected cysts are easier to dissect and allow for better preservation of the surrounding structures. In young, low-risk patients, cysts should be excised to achieve definitive tissue diagnosis and prevent future complications including fistulization or malignant degeneration [3,12,13]. In high-risk patients, small, asymptomatic inclusion cysts with benign imaging characteristics can be observed. ...
Introduction and importance
Epidermal inclusion cysts are a common benign finding, and they are predominantly asymptomatic. They can rarely form in the pelvis or abdomen, however, and may cause symptoms secondary to mass effect. This case highlights management of an anterectal epidermal inclusion cyst connected to the perineal cyst, mimicking a dumbbell-shaped lesion, found in a male.
Case presentation
This is a unique case of a 21-year-old Caucasian male with a palpable perineal mass, lower extremity hypoesthesia, and constipation who was found to have a complex-shaped cyst on computed tomography and magnetic resonance imaging. This was ultimately managed with a two-stage perineal and transabdominal resection.
Clinical discussion
This case highlights that perineal epidermal inclusion cysts may have pelvic extension, especially in patients with additional new-onset neurologic, gastrointestinal, or urologic symptoms. These symptoms should completely resolve after resection. Additionally, resection is recommended to prevent complications including malignant degeneration and fistulization.
Conclusion
This is the first reported case of an anterectal, epidermal inclusion cyst connected to a perineal cyst found in a male. Perineal and pelvic cysts may be synchronous and may be connected through the pudendal canal. These masses can be safely removed via a combined perineal and transabdominal resection. The connecting portion of lesions that have both pelvic and perineal components should be meticulously identified and dissected because even a thin, patent segment – if left unresected – may result in lesion recurrence.
... The treatment of choice for CEC is surgical resection. Since residual squamous epithelial tissues may lead to recurrence and have malignant potential, complete removal is warranted [7,8]. Although accurate preoperative diagnosis allows appropriate surgical planning and provides a good prognosis, this becomes difficult for neonatal CECs. ...
Background
Only 10 cases of cecal epidermoid cyst (CEC) have been reported in the literature. Furthermore, its pathogenesis remains unclear. We report a rare case of congenital CEC in neonate, and discuss its clinicopathological findings.
Case presentation
A cystic lesion was incidentally identified in the retroperitoneal area of the abdominal right lower quadrant during a routine prenatal ultrasonography (US), prompting an ileocolectomy 3 days after birth. This congenital cyst was composed of mucosal lining cells and submucosal connective tissues, and the inner lining mucosa was composed of stratified squamous epithelium and focally mucin-producing ciliated epithelium. Based on the macroscopic and microscopic findings, the cystic lesion was diagnosed as a congenital cecal epidermoid cyst.
Conclusions
The management of a fetal abdominal mass should be tailored individually, considering that epidermoid cysts can occur in the cecum during the perinatal period. We report the clinicopathological findings in this case, including its possible pathogenesis.
Epidermal cysts are among the most common benign subcutaneous tumors. However, malignant transformation of benign epidermal cysts into squamous carcinomas has been reported. Owing to its low incidence rate, the clinical and pathological features of this condition are not well understood. This study aimed to analyze the clinical and pathological characteristics of the malignant transformation of epidermal cysts, which could suggest an appropriate treatment strategy. We conducted a retrospective study of 9 patients diagnosed with squamous cell carcinoma arising from epidermal cysts. All patients underwent surgical excision, and clinical information regarding patient demographics, tumor characteristics, treatment, and outcomes was analyzed. The average age at diagnosis was 57.3 years, with an average latency period of 15.4 years. Five patients had undergone prior cyst excision or drainage, with an average of 2.3 episodes of recurrence. Surgical excision was the primary treatment in all cases, and 2 patients with margin involvement at the final pathology underwent re-excision with additional resection margins. No recurrence was observed during the follow-up period. Four patients had immune dysregulation due to an underlying chronic kidney disease or cancer. Our study emphasizes the need for increased awareness of squamous cell carcinoma arising from epidermal cysts in patients with a history of cyst existence or recurrence, especially those with immune deficiencies. We expect these findings to contribute to early suspicion of malignant transformation and guide adequate clinical decision-making.
BACKGROUND: Dermoid cysts (DC) are benign cystic tumors formed because of impaired embryogenesis processes when ectodermal rudiments are immersed in tissues and organs along the lines of their embryonic fusion. DC is most often localized in the head and neck (84%). Rarer localizations areas are as follows: 1) ovaries; 2) retroperitoneal space; 3) mediastinum; 4) pancreas and spleen; 5) spinal canal. In case of retroperitoneal localization of DC, the presacral location occurs more often, then location in soft tissues of the sacrococcygeal region. Moreover, the clinical pattern may be similar to that of pilonidal disease, which may cause difficulties in diagnosis at the preoperative diagnostics and further determination of the surgical techniques. CLINICAL CASES DESCRIPTION: In the Clinic of colorectal and minimally invasive surgery, two clinical cases of dermoid cysts masquerading as pilonidal sinus disease were encountered. In both cases, Bascom II surgery was performed. Macroscopic examination of the specimens revealed pathognomonic signs of dermoid cysts: a hair growth site on the epithelial lining of the cyst in the first case and the presence of sebum in the cyst cavity in the second case. The early postoperative period in both patients proceeded smoothly, and no data were obtained for recurrence in the 6- and 18-month follow-up period. CONCLUSION: Because of the similar clinical picture of pilonidal cysts and DC of the sacrococcygeal region, differential diagnosis is crucial. A wide range of minimally invasive methods are available for treating pilonidal disease; however, they are not appropriate for the treatment of DC. At present, the only radical method of treating DCs of the sacrococcygeal region is excision of the cyst without rupturing the capsule to prevent disease recurrence.
Background:
Perirectal epidermoid cysts are rare masses arising from the ectodermal germ cell layer of the hindgut and are predominantly found in middle-aged women. It is often difficult to make an accurate diagnosis of these cysts and it is equally challenging to distinguish it from other developmental cysts.
Case summary:
We report the case of an 18-year-old female patient with a perirectal mass who presented to the hospital with constipation. The patient experienced sacrococcygeal falls and burns on the left buttocks during growth. Three-dimensional computed tomography scans indicated abnormal sacral vertebrae with the sacral canal partially enlarged and opened. Pelvic magnetic resonance imaging showed a 55 mm × 40 mm × 35 mm unilocular cystic mass in the perirectal space and a solitary sinus in the left ischiorectal fossa. The cyst was completely resected posteriorly using the sacrococcygeal approach. The pathology was verified to be an epidermoid cyst. The patient remained recurrence-free after 6 mo of follow-up.
Conclusion:
Successful treatment of perirectal epidermoid cysts depends on comprehensive evaluation. This is significant for the surgical approach and prognosis.
