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![Histological features of serous cystadenofibroma. (a) Low magnification of the left ovarian tumor (hematoxylin and eosin [H&E] stain, Â10), (b) high magnification of the same tumor (H&E stain, Â40), (c) low magnification of the tumor in the great omentum (H&E stain, Â10), and (d) high magnification of the same tumor (H&E stain, Â40). Immunohistological staining in left ovarian tumor by (e) vimentin, Â10, (f) WT-1, Â10, and (g) CD-10, Â10. Immunohistological staining in great omental lesion by (h) vimentin, Â10, (i) WT-1, Â10, and (j) CD-10, Â10. The interstitium with noticeable fiber components protruded on the papilla in an extraverted direction and the surface layer was covered by ciliated cuboidal or columnar epithelium, resembling oviductal epithelium. The nuclear atypia was not observed in both ovarian tumors and peritoneal lesions. Ductal structures of varying sizes similarly lined by epithelium were also found in the interstitium. Histopathological diagnosis is serous cystadenofibroma. In immunohistochemical staining, Vimentin was positive in most of the epithelium and stroma; WT-1 was positive in most of the epithelium; CD10 was almost negative. These findings were consistent with serous cystadenofibroma. Peritoneal lesions and great omental lesions have almost similar immunohistochemical characteristics](publication/354407709/figure/fig2/AS:1065400284495874@1631022630834/Histological-features-of-serous-cystadenofibroma-a-Low-magnification-of-the-left.png)
Histological features of serous cystadenofibroma. (a) Low magnification of the left ovarian tumor (hematoxylin and eosin [H&E] stain, Â10), (b) high magnification of the same tumor (H&E stain, Â40), (c) low magnification of the tumor in the great omentum (H&E stain, Â10), and (d) high magnification of the same tumor (H&E stain, Â40). Immunohistological staining in left ovarian tumor by (e) vimentin, Â10, (f) WT-1, Â10, and (g) CD-10, Â10. Immunohistological staining in great omental lesion by (h) vimentin, Â10, (i) WT-1, Â10, and (j) CD-10, Â10. The interstitium with noticeable fiber components protruded on the papilla in an extraverted direction and the surface layer was covered by ciliated cuboidal or columnar epithelium, resembling oviductal epithelium. The nuclear atypia was not observed in both ovarian tumors and peritoneal lesions. Ductal structures of varying sizes similarly lined by epithelium were also found in the interstitium. Histopathological diagnosis is serous cystadenofibroma. In immunohistochemical staining, Vimentin was positive in most of the epithelium and stroma; WT-1 was positive in most of the epithelium; CD10 was almost negative. These findings were consistent with serous cystadenofibroma. Peritoneal lesions and great omental lesions have almost similar immunohistochemical characteristics
Source publication
Ovarian serous cystadenofibroma is a relatively rare subtype of serous cystadenoma classified as ovarian benign epithelial tumor. We report a rare case of ovarian serous cystadenofibroma with scattered lesions in pelvic cavity, like malignant disseminations. The patient was 22 years old, gravida 0, para 0. In the laparoscopic surgery, numerous hard...
Contexts in source publication
Context 1
... cyst cavities are filled with watery fluid. Microscopically, the broad exophytic papillae are lined by single-layered, focally ciliated cuboidal or columnar cells (Figure 3(a,b)). These cells have scant pale eosinophilic cytoplasm, oval or rounded nuclei, and show mild nuclear stratification. ...
Context 2
... omental tumors and peritoneal nodules are small hard whitish masses composed of cystic spaces and compact stroma with focal calcification. The surface of them has broad-based papillae and the lining cells are also the same as those of the bilateral ovaries (Figure 3(c,d)). In immunohistological staining, Vimentin was positive in most of the epithelium and stroma; WT-1 was positive in most of the epithelium; CD10 was almost negative (Figure 3(e,f,g). ...
Context 3
... surface of them has broad-based papillae and the lining cells are also the same as those of the bilateral ovaries (Figure 3(c,d)). In immunohistological staining, Vimentin was positive in most of the epithelium and stroma; WT-1 was positive in most of the epithelium; CD10 was almost negative (Figure 3(e,f,g). These immunohistological findings were consistent with serous cystadenofibroma. ...
Context 4
... similar immunohistochemical characteristics were observed in both peritoneal scattered lesions in the oviduct and great omentum. No interstitial infiltration was observed (Figure 3(c,d,h,i,j)). The postoperative course was uneventful and the patient was discharged on the fourth day. ...
Citations
... [11] However, the Ovarian serous cystadenofibroma is a rare benign ovarian tumor characterized by the presence of cystic structures lined by serous epithelial cells in a fibrotic stroma. [12] It is hard to distinguish this type of benign ovarian tumor from malignancy due to the similarity of imaging features of the two conditions on ultrasonography, CT, or MRI. One study found that some ovarian serous cystadenofibromas had pure cystic lesions, while the rest had cystic components with thick or irregular septa. ...
Rationale:
Ovarian cystadenofibroma is a relatively rare benign ovarian tumor. Ovarian remnant syndrome (ORS) is a rare complication of bilateral salpingo-oophorectomy (BSO). We report a rare case of ORS with paraintestinal ovarian serous cystadenofibroma that developed 30 years after total abdominal hysterectomy and BSO in a 73-year-old woman.
Patient concerns:
A 73-year-old woman complained of long-term lower abdominal discomfort.
Diagnosis:
She was diagnosed with a cystic lesion in the lower abdomen on transabdominal ultrasonography. Further diagnostic imaging and laboratory tests could not exclude a diagnosis of malignancy.
Interventions:
The patient underwent laparoendoscopic single-site surgery. We found one cystic lesion 5 cm in size with multiple septa that was adhered to the small bowel. We consulted a general surgeon for tumor resection. Dissection was performed and the specimen was then removed from the umbilical wound.
Outcomes:
Histopathological examination revealed an ovarian serous cystadenofibroma. The postoperative recovery was uneventful.
Lessons:
Patients with lower abdominal pain after a previous hysterectomy and BSO should be examined with transabdominal sonography for ORS.
OBJETIVO:
Analizar retrospectivamente las características clínicas, radiológicas, histopatológicas, y la atención médica de las pacientes.
MATERIALES Y MÉTODOS:
Análisis retrospectivo y descriptivo de pacientes con diagnóstico histopatológico de cistoadenofibroma seroso de ovario atendidas en el Hospital General de Albacete entre los años 2010 a 2022.
RESULTADOS:
Se analizaron 635 piezas quirúrgicas, de las que el 57.74% correspondieron a neoplasias serosas benignas, el 17.41% a neoplasias serosas fronterizas y un 24.85% a neoplasias serosas malignas. Se identificaron 20 casos de pacientes con diagnóstico de cistoadenofibroma seroso de ovario. La edad media de esas pacientes fue de 47 años, con límites de 9 y 74 años. Un caso se asoció con un tumor proliferativo seroso atípico contralateral. El tratamiento fue quirúrgico y no se identificaron recurrencias en ninguno de los casos.
CONCLUSIONES:
El cistoadenofibroma seroso suele manifestarse como un quiste ovárico complejo, con componentes sólidos-quísticos y tabiques irregulares; por esto a menudo se diagnostica erróneamente como tumor maligno antes de la intervención. La biopsia por congelación ayuda a confirmar su naturaleza benigna y evita una cirugía extensa innecesaria. El tratamiento consiste, principalmente, en la extirpación quirúrgica del quiste con o sin ooforectomía. El pronóstico suele ser excelente.
Primary cystic neoplasms in the liver with ovarian type stroma typically represent mucinous cystic neoplasms. These tumors contain a cuboidal to columnar epithelium with variably mucinous cytoplasm. To the best of our knowledge, there are no reports of primary hepatic cystic neoplasms with ovarian-type stroma and ciliated epithelial lining. We describe a case of a 53-year-old woman with a history of a multicystic mass in the right hepatic lobe that did not communicate with the biliary tree. The tumor contained multiple cysts with large papillae lined with ciliated Mullerian epithelium and subepithelial ovarian-type stroma.
