Histological features of a high-grade endometrial stromal sarcoma. a) Th e tumour contained small and moderately sized cells, with scant cytoplasm and blurred cell boundaries (HE staining technique, x200). Immunohistochemically, the tumour cells were diff usely positive for only b) vimentin, (x400) and remained negative for c) CKAE1/AE3 (x200) and d) CD10 (x400). 

Contexts in source publication

Context 1

... 50-year-old female patient was admitted to the ward due to redness of the palms and soles and guttate scaly plaques covering the body surface. She had a 5-year his- tory of festering blisters and redness on the soles of her feet Figure 1). The plaques appeared during the summer and disappeared during the winter, during which the patient was not treated. One month before her admission, the normal changes occurred on her palms (Figure 2), and less intensely coloured plaques appeared on her trunk and extremities (Figures 3 and 4). She had smoked for 28 years and denied any other symptoms, allergy, and other diseases. The skin of her palms and soles was covered with numerous pustules and dark remnants of erythaema followed by desquamation. There were scaly individual plaques, up to 1 cm in diameter, on the skin of her trunk and ...

Context 2

... neuroborreliosis (LNB) is a disease of the central nervous system (CNS) and/or peripheral nervous system (PNS) caused by the spirochete Borrelia burgdorferi (Bb) as part of a general infection referred to as Lyme borreliosis (LB) or Lyme disease (1, 2). In Europe, LNB is caused by Bb sensu lato-mainly Borrelia garinii and Borrelia afzelii- and rarely Bb sensu stricto, whereas in North America, the only bacterium is Bb sensu stricto (3, ...

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... the existence of two morphological- ly distinct tumours was confirmed. HE staining showed characteristics similar to the tissues of the uterus, cervix and fallopian tubes. The tumour was present in all layers of the uterus wall, with infiltrations into the cervix and fallopian tubes. The tumour contained extensive areas of necrosis and areas of angioinvasion and was composed of small and moderately sized cells, with scant cytoplasms and blurred cell boundaries. The nuclei were vesicular, with prominent nucleoli and numerous mitotic figures (over 30/10 HPF) (Figure 3a). Immunohistochemically, the tumour cells were diffusely positive for only vimentin and remained negative for CD10, S-100, actin, desmin, LCA, EMA, CKAE1/AE3, ER, PR and CA125 (Figure 3b-d). Based on the microscopic analysis and the tumour cell immunophenotype, the diagnosis of a high-grade en- dometrial stromal sarcoma, FIGO stage IIIa, was made. 3 A microscopic analysis of the HE-stained samples that matched the cyst found in the right ovary revealed a tu- mour composed of pseudo-glandular, cribriform and solid areas of atypical, cylindrical and cuboidal cells with eosinophilic cytoplasms (Figure 4a). The nucleoli were hyperchromatic or vesicular, with a moderate number of mitotic figures. The stoma was relatively sparse and contained an inflammatory mononuclear cell infiltrate (Figure 4b). Immunohistochemically, the tumour cells were positive for CK7, CA125, ER and PR and remained negative for vimentin and CEA. The proliferation index was intermediate, with approximately 25% of the nuclei expressing Ki-67 (Figure 4c-f ). Based on the immunophe- notype, the diagnosis of a moderately differentiated en- dometrioid carcinoma of the ovary with no tumour ex- tension (FIGO Ia stage) was made. The left ovary, lymph nodes, and tissue samples of the omentum and peritone- um were all free of tumour deposits. Finally, a cytological analysis of the peritoneal lavage fluid showed no presence of malignant cells. Histological features of a high-grade endometrial stromal sarcoma. a) Th e tumour con- tained small and moderately sized cells, with scant cytoplasm and blurred cell boundaries (HE stain- ing technique, x200). Immuno- histochemically, the tumour cells were diff usely positive for only b) vimentin, (x400) and remained negative for c) CKAE1/AE3 (x200) and d) CD10 ...

Context 4

... the existence of two morphological- ly distinct tumours was confirmed. HE staining showed characteristics similar to the tissues of the uterus, cervix and fallopian tubes. The tumour was present in all layers of the uterus wall, with infiltrations into the cervix and fallopian tubes. The tumour contained extensive areas of necrosis and areas of angioinvasion and was composed of small and moderately sized cells, with scant cytoplasms and blurred cell boundaries. The nuclei were vesicular, with prominent nucleoli and numerous mitotic figures (over 30/10 HPF) (Figure 3a). Immunohistochemically, the tumour cells were diffusely positive for only vimentin and remained negative for CD10, S-100, actin, desmin, LCA, EMA, CKAE1/AE3, ER, PR and CA125 (Figure 3b-d). Based on the microscopic analysis and the tumour cell immunophenotype, the diagnosis of a high-grade en- dometrial stromal sarcoma, FIGO stage IIIa, was made. 3 A microscopic analysis of the HE-stained samples that matched the cyst found in the right ovary revealed a tu- mour composed of pseudo-glandular, cribriform and solid areas of atypical, cylindrical and cuboidal cells with eosinophilic cytoplasms (Figure 4a). The nucleoli were hyperchromatic or vesicular, with a moderate number of mitotic figures. The stoma was relatively sparse and contained an inflammatory mononuclear cell infiltrate (Figure 4b). Immunohistochemically, the tumour cells were positive for CK7, CA125, ER and PR and remained negative for vimentin and CEA. The proliferation index was intermediate, with approximately 25% of the nuclei expressing Ki-67 (Figure 4c-f ). Based on the immunophe- notype, the diagnosis of a moderately differentiated en- dometrioid carcinoma of the ovary with no tumour ex- tension (FIGO Ia stage) was made. The left ovary, lymph nodes, and tissue samples of the omentum and peritone- um were all free of tumour deposits. Finally, a cytological analysis of the peritoneal lavage fluid showed no presence of malignant cells. Histological features of a high-grade endometrial stromal sarcoma. a) Th e tumour con- tained small and moderately sized cells, with scant cytoplasm and blurred cell boundaries (HE stain- ing technique, x200). Immuno- histochemically, the tumour cells were diff usely positive for only b) vimentin, (x400) and remained negative for c) CKAE1/AE3 (x200) and d) CD10 ...