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Hierarchical clustering analysis of miRNA expression of early cerebral aneurysms and control cerebral arteries. miRNAs are presented in rows and samples are presented in columns. Colors indicate relative signal intensities; red and blue colors indicate up-expressed and down-expressed miRNAs, respectively.
Source publication
Structural adaptation of the vascular wall may occur due to various factors, such as shear stress, pressure, injury or inflammation. The role of microRNAs (miRNAs) in the development of vascular remodeling has been investigated in several studies. Recently, the authors reported altered expression profiles of miRNAs in late stage of experimentally i...
Context in source publication
Context 1
... relative expression levels of the miRNA were found to be significantly different between these two groups as shown in Figure 2. Fold change filters included the require- ments that the genes be present in more than 200% of con- trols for over-expressed miRNA and less than 50% of con- 3.00 2.00 1.00 0.00 -1.00 -2.00 -3.00 ...
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Citations
... miR-448 is reportedly associated with various human malignancies. It is upregulated in breast cancer and early cerebral aneurysm (12,13), indicating regulatory effects of miR-448 in various conditions. ...
... miR-448 has been reported to be associated with various types of cancer. It is upregulated in breast cancer (24) and early cerebral aneurysm (12), and downregulated in hepatocellular carcinoma (25) . It has also been reported that miR-448 is the most downregulated microRNA following chemotherapy in breast cancer (13), suggesting that it may act as an oncogene or anti-oncogene in different cancers. ...
The incidence of oral squamous cell carcinoma (OSCC) is continuously increasing while its survival rate has not notably improved. There is a pressing need for improved understanding of the genetic regulation of OSCC tumorigenesis and progression. In this study, the function of miR-448 in the regulation of OSCC growth and its putative target were thoroughly analyzed in vitro. The expression of miR-448 was detected in human OSCC specimens and OSCC cell lines (Cal-27 and Scc-9) by reverse transcription-quantitative polymerase chain reaction. The function of miR-448 was investigated in Cal-27 cells transfected with miR-448 inhibitor, and its putative target determined using a luciferase reporter assay. MTT and wound healing assays and flow cytometry were used to evaluate the effects of miR-448 on OSCC proliferation, metastasis and apoptosis. The level of miR-448 was significantly elevated in human OSCC tissues and the Cal-27 cell line. Suppression of miR-448 expression attenuated cell proliferation and migration, and induced apoptosis of Cal-27 cells. Furthermore, miR-448 bound with the 3’-untranslated region of metallophosphoesterase domain containing 2 (MPPED2) mRNA, thereby reducing the MPPED2 protein level. Thus, it appears that miR-448 acts as a tumor inducer, causing OSCC growth by inhibiting the expression of its target MPPED2. These results demonstrate that miR-448 plays a critical role in OSCC tumorigenesis, and is a potential therapeutic target.
