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Hematoxylin and eosin staining of representative interparietal skull bone samples from sham and 2 × mTBI rats, at 10 weeks post-injury. A larger volume of trabecular bone is evident in the 2 × mTBI sample compared to sham, alongside a reduction in the volume of marrow cavities (arrows). Scale bar = 200 µm.

Hematoxylin and eosin staining of representative interparietal skull bone samples from sham and 2 × mTBI rats, at 10 weeks post-injury. A larger volume of trabecular bone is evident in the 2 × mTBI sample compared to sham, alongside a reduction in the volume of marrow cavities (arrows). Scale bar = 200 µm.

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While it is well-established that bone responds dynamically to mechanical loading, the effects of mild traumatic brain injury (mTBI) on cranial bone composition are unclear. We hypothesized that repeated mTBI (rmTBI) would change the microstructure of cranial bones, without gross skull fractures. To address this, young adult female Piebald Viral Gl...