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Heat-map visualization of longitudinal serum steroid profile results in 5 female and 5 male patients who developed recurrent or progressive disease during follow-up. 5 female patients, from left to right, including 3 cases in whom steroid profiling already indicated progressive disease before
Source publication
Serum liquid chromatography–tandem mass spectrometry (LC–MS/MS) steroid profiling is used for the diagnosis of adrenocortical carcinoma (ACC). Guidelines recommend endocrine work-up in addition to radiological imaging for follow-up in ACC, but data on this topic are scarce. Patients were included in this retrospective study if pre-therapeutic hormo...
Contexts in source publication
Context 1
... two (13.3%) of 15 patients in cohort A and in 18 (24.3%) of 74 cases in cohort B at least three steroid hormones were already elevated before the recurrence or progressive disease could be detected by radiologic imaging. Representative examples are given in Figure 2. In these 20 cases, recurrence or disease progression was detected after a median of 301 (118-626) days with radiologic imaging whereas the endocrine alterations were already visible after 234 (89-540) days (p < 0.001). ...
Context 2
... two (13.3%) of 15 patients in cohort A and in 18 (24.3%) of 74 cases in cohort B at least three steroid hormones were already elevated before the recurrence or progressive disease could be detected by radiologic imaging. Representative examples are given in Figure 2. In these 20 cases, recurrence or disease progression was detected after a median of 301 (118-626) days with radiologic imaging whereas the endocrine alterations were already visible after 234 (89-540) days (p < 0.001). ...
Context 3
... was no single case in which steroids were elevated that were preoperatively within the normal range. Male patients Figure 2. Heat-map visualization of longitudinal serum steroid profile results in 5 female and 5 male patients who developed recurrent or progressive disease during follow-up. ...
