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. Sarcoidosis is a rare multisystemic granulomatous inflammatory disease of unknown etiology affecting the respiratory system, skin, and eyes. Sarcoidosis outside the lacrimal gland is rare. The case study concerns a patient with a final diagnosis of orbital sarcoidosis.
Case Report
. A 37-year-old male patient went to the ophthalmic emergency room...
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A rhomboid blepharoplasty can be used to achieve functional and cosmetic eyelid reconstruction at the medial canthus in the horse. Combination of a rhomboid blepharoplasty with cryotherapy is a treatment option for eyelid ocular squamous cell carcinomas.
Citations
... Sarcoidosis is a generalized chronic multi-systemic inflammation. It has a predilection for females in their fifth to seventh decades of life and patients of African descent (3) . Ophthalmic involvement occurs in almost 25% of patients with sarcoidosis, manifesting mostly as chronic uveitis, with orbital involvement representing <1% of the ophthalmic manifestations (1,4) . ...
Sarcoidosis is a generalized systemic chronic inflammation that rarely involves the orbit. As a chronic inflammation, sarcoidosis typically manifests with an insidious onset and slowly progressive course. We report a case of acute-onset proptosis resulting from a rapidly growing diffuse orbital mass that simulated malignant growth, which was biopsy proven to be the first manifestation of systemic sarcoidosis. The patient demonstrated complete resolution of proptosis and systemic involvement with long-term corticosteroid treatment.
Keywords:
Sarcoidosis; Orbit/pathology; Exophthalmos; Lymphadenopathy
... 33 Petrarolha et al reported a case of a patient with eyelid swelling, diplopia and decreased visual acuity in one eye, who presented extraocular muscle involvement (lateral rectus, inferior rectus and inferior oblique). 59 Mavrikakis and Rootman reported four patients (20% of their patients) with optic nerve sheath and dural involvement due to orbital sarcoidosis. 53 Vahdani and Rose retrospectively reviewed patients with sarcoid-like granulomatous orbitopathy presenting between 1990 and 2018, excluding solely lid or lacrimal system disease. ...
... 60 In 2007, a multicentre study retrospectively evaluated a series of 26 patients with orbital and ocular adnexa involvement by sarcoidosis. 59 Treatment included steroids (oral prednisolone: nineteen patients, 73.1%; intraorbital injection: one patient, 3.8%), surgical removal (ten patients, 38.5%) and methotrexate (four patients, 15.4 %). The steroid dose ranged from 25 to 80 mg. ...
Sarcoidosis is a chronic multisystemic disease of unknown aetiology, characterised by non-caseating granulomas. Ocular involvement rate ranges from 30% to 60% among individuals with sarcoidosis, and can vary widely, making the diagnosis a challenge to the ophthalmologist. Cutaneous manifestations occur in about 22% of sarcoidosis cases, but eyelid involvement is rare. Eyelid swelling and nodules are the most frequent forms of eyelid involvement, but other findings have been reported. The joint analysis of clinical history, ancillary exams and compatible biopsy is needed for the diagnosis, as well as the exclusion of other possible conditions. This review aims to describe the different forms of presentations, the clinical reasoning and treatment options for ocular, eyelid and orbital sarcoidosis.
Zusammenfassung
Dieser Übersichtsartikel stellt eine Zusammenstellung seltener Erkrankungen der Orbita dar. Es werden angeborene Fehlbildungen und strukturelle Läsionen, entzündliche Erkrankungen, gutartige und bösartige epitheliale sowie nicht epitheliale Tumoren erörtert. Da in der Orbita zahlreiche Gewebetypen auf engstem Raum beieinanderliegen, kommen dort besonders viele Erkrankungen vor, sodass der Vollständigkeit und dem Tiefgang bei den einzelnen Abhandlungen natürliche Grenzen gesetzt sind. Die Kapitel beinhalten eine Übersicht über das jeweilige klinische Erscheinungsbild, wichtige Stichpunkte zur Diagnostik, Therapie und gegebenenfalls zur Prognose der Erkrankung. Dabei wurde versucht, die besonders charakteristischen Merkmale der einzelnen Erkrankungen herauszuarbeiten, sodass trotz der kurzen Darstellung die relevanten Aspekte enthalten sind.
Purpose: To report three cases of eyelid involvement by sarcoidosis. In one of them, it mimicked a malignant lesion.
Methods: Retrospective case reports.
Results: A 73-year-old man presented with destruction of the left lower eyelid for 2 years. He had granulomatous uveitis in the left eye. Chest CT scan showed parenchymal abnormalities that could correspond to sarcoidosis. Skin biopsy revealed noncaseating granuloma. Oral and topical corticosteroids resulted in improvement of the condition. A 72-year-old female patient presented with cutaneous infiltration of the left upper eyelid for 1 month. Biopsy was consistent with sarcoidosis. Endobronchial biopsies showed interstitial fibrosis. Oral prednisone improved the condition. A 65-year-old female patient presented with edema of the right upper eyelid for 2 months. Full-thickness biopsy showed granuloma without necrosis. There was an improvement with oral steroid.
Conclusion: Although eyelid involvement in sarcoidosis is uncommon, different forms of presentation, including destructive lesions, can be observed.
