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Haplotype block map for SNPs of the ACYP2 gene. Linkage disequilibrium plots containing 11 SNPs from ACYP2. Red squares display statistically significant associations between a pair of SNPs, as measured by D’; darker shades of red indicate higher D’
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Background
Gastrointestinal cancer (GI cancer) is a type of cancer that has a high death rate. It has been reported that ACYP2 gene was associated with the development of gastric cancer and colorectal cancer, but it is not clear that the relationship between ACYP2 gene and GI cancer in Chinese Han population. This study aimed to investigate the ass...
Citations
... o glioma(M. o liver cancer (Chen et al., 2017;Zhao, Liu, et al., 2019) o renal cancer (Wang et al., 2019) o gastrointestinal cancer (Duan et al., 2019) o laryngeal squamous cell cancer (Zhao, Niu, et al., 2019) o increase the risk of cisplatin-induced ototoxicity (Thiesen et al., 2017) o be associated with non-cancer illness: immunoglobulin A nephropathy (Drogemoller et al., 2018;Jin et al., 2019) The previous literature did not clarify the underlying mechanisms between ACYP2 gene expression and shortened telomeres. Similarly to CARMIL-1, neither association nor hypothesis on potential mechanism was previously described in relation to white matter hyperintensities, hippocampal volumes or fibrosis. ...
Background and aim: This study looked at the genetic aspects that influence telomere length and their link to healthy brain and cerebrovascular ageing.
Methods: Using sample data from UK Biobank, we looked into the association between 29 SNPs regulating telomere length and neuroimaging biomarkers of ageing and cerebrovascular disease (hippocampus, white matter hyperintensities [WMH]). The analysis was corrected for technical variables as well as clinical, demographic and lifestyle factors to correct for nuisance variables, including ApoE status due to the well-known association with cardiovascular disease and hippocampal atrophy. We used descriptive statistics and correlation
analysis for the baseline assessment. Furthermore, we used variance inflation factor to select variables lacking significant co-linearity and performed linear regression for three dependent imaging-derived phenotypes (log WMHs, right hippocampus, left hippocampus). We used Bonferroni correction on the final models for interpretation.
Results: The final regression models included technical confounders, genetic data and clinical, and demographic and lifestyle factors. They explained 34.6% of the variation in right hippocampal volume, 40.6% of the left total hippocampal volume, and 36.1% of the variation in log WMHs volume. As an interim step to correct for known associations, we identified the following factors contributing to WMHs load: smoking status, physical activity, diabetes diagnosed by a doctor, number of medications including medications for hypertension, HbA1c, waist to hip, pulse rate, and blood pressure (systolic and diastolic). We have also identified the following contributory factors for hippocampal volume on both sides: smoking status, maternal longevity, waist to hip ratio. Additionally, we identified paternal age and systolic blood pressure for the left hippocampus, and arterial stiffness, diastolic blood pressure and a number of non-cancerous diseases for the right hippocampus. The overall analysis uncovered that ApoE is the only genetic contributor for all three biomarkers (WMHs, right and left hippocampus), on its own, explaining 0.01% of variability for each. Two SNPs localised on chromosome 10 (rs11191848 and rs9419958) were associated with shorter telomere length and increased WMHs, on its own explaining 0.01% of the variability and 0.03% when combined.
Discussion and limitations: We refuted the hypothesis on the link between SNPs regulating telomere length and hippocampal volume, which is consistent with the negative meta-analysis by Nielsen et al. looking at the association of direct leucocyte telomere length and hippocampal volume. We identified two SNPs influencing WMHs, out of which rs11191848 was previously reported to be associated with cardiovascular disorders. Limitations of this study were lack of direct telomere length, lack of longitudinal data, and analysis restricted to the Caucasian population between 40 and 85 years.
Conclusions:
ApoE were the only consistent genetic contributor to the neuroimaging
biomarkers of brain ageing and cerebrovascular health. There is a link
between rs11191848 and rs9419958 contributing to shorter telomere length and increased WMHs load, but no link between hippocampal volumes and SNPs regulating telomere length. Further studies are needed better to understand direct leucocyte telomere length on neuroimaging biomarkers and uncover potential mechanisms for those relationships
... A total of 10 case-control studies with 5,230 cases and 5,086 controls for thirteen polymorphisms of ACYP2 gene met the inclusion criteria. [14][15][16][17][18][19][20][21][22][23] Nine studies of them were performed in Asians, one study was performed in Mix ethnicity. Controls of 6 studies were population-based controls, and 4 studies were hospital-based controls. ...
... The pooled results based on 6 included studies (including 1,873 cases and 2,349 controls) indicated that rs17045754 was significantly related to an [16,[18][19][20][21][22] (Figure 4, Table 3 [16,17,[19][20][21]23] (Figure 5, Table 3). ...
... Many studies have identified that there is a strong linkage disequilibrium (LD) between each pair of eight SNPs (rs1682111, rs843752, rs10439478, rs843645, rs11125529, rs12615793, rs843711, and rs11896604) of ACYP2 gene. [17,20,21,23] However, the results of various studies are not consistent, so it is necessary to analyze each SNP of ACYP2 gene. ...
To provide a comprehensive account of the association of ACYP2 gene polymorphisms with susceptibility to cancer. A literature search for eligible candidate gene studies published before April 20, 2022 was conducted in the PubMed, Medline and Web of Science. The following combinations of main keywords were used: (ACYP2 OR acylphosphatase 2) AND (polymorphism OR mutation OR variation OR SNP OR genotype) AND (cancer OR tumor OR neoplasm OR malignancy OR carcinoma OR adenocarcinoma). Potential sources of heterogeneity were sought out via subgroup and sensitivity analysis. Publication bias were also estimated. Overall, a total of 10 articles with 5,230 cases and 5,086 controls for thirteen polymorphisms of ACYP2 gene were enrolled. We found that ACYP2 rs11125529, rs11896604, rs12615793, rs17045754, rs6713088, rs843645, rs843706, rs843711 and rs843752 were correlated with an increased risk of cancer. However, we found that ACYP2 rs12621038 might have less susceptibility to cancer. While for other polymorphisms, the results showed no significant association with cancer risk. ACYP2 rs11125529, rs11896604, rs12615793, rs17045754, rs6713088, rs843645, rs843706, rs843711 and rs843752 are associated with cancer risk. ACYP2 rs12621038 polymorphism is inversely associated with cancer risk.
... [3] The early symptoms of GIT cancers are not obvious and they are easily misdiagnosed with other diseases. [4,5] In recent years, many anticancer strategies and the mechanisms have been explored. [6][7][8][9] Despite the great improvements in the diagnosis and treatment of GIT cancers, the 5-year survival rate is still low, especially colorectal cancer, gastric cancer and esophageal cancer. ...
... [6][7][8][9] Despite the great improvements in the diagnosis and treatment of GIT cancers, the 5-year survival rate is still low, especially colorectal cancer, gastric cancer and esophageal cancer. [5] Therefore, it is worthwhile to explore new prognostic biomarkers and potential therapeutic targets for better management of GIT cancers. ...
Background:
The aim of this meta-analysis was to systematically evaluate the prognostic significance of X-linked inhibitor of apoptosis protein (XIAP) in patients with gastrointestinal tract (GIT) cancers.
Methods:
PubMed, Web of Science, EMBASE, Cochrane Library and China National Knowledge Infrastructure were searched for potentially eligible literature. The baseline characteristics and relevant data were extracted. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated to assess the prognostic role of XIAP in patients with GIT cancers.
Results:
Twelve studies with 2,477 patients were included. The pooled HRs of higher expression of XIAP for overall survival (OS) and recurrence free survival (RFS) in patients with GIT cancers were 1.64 (95% CI, 1.27-2.13) and 1.06 (95% CI, 0.96-1.16), respectively. Subgroup analysis and sensitivity analysis were also performed. No significant publication bias was found.
Conclusion:
Our results suggested that XIAP could be a prognostic marker for OS but not RFS in patients with GIT cancers. Higher expression of XIAP was related to poorer OS. These findings may help evaluate the prognosis of patients and assist future research on novel therapeutic strategies of GIT cancers by targeting XIAP. However, more well-designed studies are warranted to verify the results.
Background: Hyperthermic intraperitoneal chemotherapy (HIPEC) may prolong the survival of patients with peritoneal carcinomatosis. The purpose of this study was to investigate whether dexmedetomidine protects liver and kidney function during HIPEC.
Methods: Sixty gastrointestinal cancer patients undergoing HIPEC were divided into two group. Patients in Dex group were received an intravenous infusion of dexmedetomidine until operation completed. The indexes about liver and kidney function and oxidative stress like malondialdehyde (MDA) and superoxide dismutase (SOD) were measured at different points.
Results: After HIPEC, these increases of renal damage markers were alleviated by Dex administration (P<0.05). Dex significantly alleviated the increased MDA concentration and decreased SOD activity caused by HIPEC (P<0.05). Dex also provide lower HR, bispectral index (BIS) and visual analogue scale (VAS), and more urine output(P<0.05).
Conclusion: Dex alleviated the impairment of renal function induced by HIPEC, which may be related to its better effects of analgesic, sedation and antioxidant.
