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Renal transplantation is the most successful treatment option for chronic renal failure patients. But success of this depends on HLA antigen matching between the renal recipient & donor. This study is the first report from Karnataka state of South India to find out distribution of HLA-A and B antigens in live renal transplant recipients and donors...
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Background
Polycystic ovary syndrome (PCOS) is a common female endocrinal disease that may result in excessive androgen, but the mechanism of PCOS remains unclear. Most patients with PCOS suffer from low-grade inflammation, whereas the underlying connection between immune and PCOS is still uncertain.
Objective
This study aimed to determine the imm...
Major Histocompability Complex (MHC) Class I molecules allow cells to present foreign and endogenous peptides to T-Cells so that cells infected by pathogens can be identified and killed. Neural networks tools such as NetMHC-4.0 and NetMHCpan-4.1 are used to predict whether peptides will bind to variants of MHC molecules. These tools are trained on...
Purpose
The association of human leucocyte antigen (HLA) class I expression levels with the clinical course of many malignancies reflects their crucial role in the recognition and elimination of malignant cells by cognate T cells and NK cells. In colorectal cancer, results regarding this association are conflicting. The potential pathogenetic and t...
Sudan is located in the heart of Africa and surrounded by eight
countries with people of different ethnic origins. Historical records
show that the population of the Sudan is a mixture of Arabic, West
Asian Arabic and sub-Saharan African elements. The present survey
provides data on allele lineages, and haplotype frequencies of
Human Leukocyte Anti...
Introduction:
The human leukocyte antigen (HLA) region on chromosome 6p21 is well known to carry the most important genetic factors in susceptibility to psoriasis. Different HLA alleles and haplotypes have been reported to be associated with psoriasis in different populations. Psoriasis has a variable age of onset and, based on this, it can be cla...
Citations
... B*51 (8.8%), and B*44 (7.6%) were in the list of most frequent allele. [9] This showed some similarity with our results like HLA-A*02, A*11, HLA-B*35, DRB1*07 were found to be most frequent in our study. Kankonkar et al., identified HLA-A*02 (19.25%), ...
Background: The understanding of transplant acceptance or rejection derives directly from knowing human leukocyte antigen (HLA) involved
in the immune response. The HLA of the major histocompatibility complex contains a numerous family of genes located on the short arm of the
chromosome number 6 and divided majorly into two classes, Class I (HLA‑A, B, and C) and Class II (HLA‑DR, DQ, and DP). The detection and
detailed information of these histocompatibility genes are essential for the better outcome of organ transplants. Aims and Objectives: The aim
of the present study is to analyze the frequencies of HLA‑A, B, and DRB1 in chronic kidney disease (CKD) patients and their prospective donors
as well as to see the prevalence of heterogenicity. Materials and Methods: A total of 264 patients diagnosed with CKD and 333 potential donors
were studied retrospectively in the present study. All these cases were analyzed for HLA‑A, B, and DRB1 loci typing by PCR‑SSOP method
based on the Luminex platform. Results: We identified 15 different alleles of HLA‑A, 29 of HLA‑B, and 13 of HLA‑DRB1 amongst studied
samples. Out of these identified HLA alleles, HLA‑A*02, HLA‑B*35, and HLA‑DRB1*15 were more frequent as compared to others. The results
showed significant heterogenicity in the identified HLA‑A, B, and DRB1alleles. Conclusion: The result highlights the diversity of HLA‑A, B, and
DRB1 alleles and is valuable as a reference for organ transplantations. Further, these findings can also guide in better donor selection and hence
improved transplant outcome. In addition, this information could be a starting point for the development of an indigenous transplant assay kit
