Figure 5 - available via license: Creative Commons Attribution 4.0 International
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H&E staining and histological analysis of the effect of SOCS-com gene-transfected ADMSCs on the reconstruction of the dermis and epidermis of pressure ulcer mice at days 5 (A) and 15 (B). Inflammatory infiltration into muscle cells with SOCS-com-transfected ADMSCs in the mouse models was also observed in the bottom box of each figure. Black arrow: intact epithelium; orange arrow: broken epithelium; yellow arrow: aggregation of inflammatory cells, mainly macrophages and polymorphonuclear cells; red arrow: loosely packed connective tissue; green arrow: hematoma. (C,D) The number of overall inflammatory cells was determined. The statistical significance was assessed using a Kruskal-Wallis test. (* p < 0.05 vs. control; # p < 0.05 vs. normal; ns p > 0.05 vs. control).
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Although the proportion of ulcer patients with medical problems among the elderly has increased with the extension of human life expectancy, treatment efficiency is drastically low, incurring substantial social costs. MSCs have independent regeneration potential, making them useful in clinical trials of difficult-to-treat diseases. In particular, A...
Contexts in source publication
Context 1
... evaluate whether co-transfection with SOCS-com promoted the recovery of the damaged skin structure, histopathological analysis via H&E staining was performed ( Figure 5). On day 5, inflammatory cells and loose connective tissue were also observed in the group in which ADMSCs were transfected with the vector, but the extent was not as severe as that in the PU model. ...
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... damaged epidermal and dermal layers in the SOCS-com group partially recovered, with some inflammatory cell infiltration in the damaged epithelium. However, the overall inflammatory cell infiltration was significantly reduced in the SOCS-com group, suggesting that the wound was beginning to heal after SOCS-com transfection ( Figure 5A). ure 5). ...
Context 3
... damaged epidermal and dermal layers in the SOCS-com group partially recovered, with some inflammatory cell infiltration in the damaged epithelium. However, the overall inflammatory cell infiltration was significantly reduced in the SOCS-com group, suggesting that the wound was beginning to heal after SOCS-com transfection ( Figure 5A). ...
Context 4
... the dermis of the vector group exhibited loose connectivity similar to that of the PU group. In contrast, the dermal tissue exhibited a dense and well-connected structure, and the epidermal and dermal layers were fully restored in the SOCS-com group ( Figure 5B). In addition, the overall number of inflammatory cells was dramatically reduced (Figure 5C,D). ...
Context 5
... contrast, the dermal tissue exhibited a dense and well-connected structure, and the epidermal and dermal layers were fully restored in the SOCS-com group ( Figure 5B). In addition, the overall number of inflammatory cells was dramatically reduced (Figure 5C,D). Taken together, the comprehensive histological results indicated that co-transfection with SOCS-com reduced the widespread inflammation response and accelerated the woundhealing process the most, demonstrating its superior therapeutic potential. ...
Context 6
... the dermis of the vector group exhibited loose connectivity similar to that of the PU group. In contrast, the dermal tissue exhibited a dense and well-connected structure, and the epidermal and dermal layers were fully restored in the SOCS-com group ( Figure 5B). In addition, the overall number of inflammatory cells was dramatically reduced (Figure 5C,D). ...
Context 7
... contrast, the dermal tissue exhibited a dense and well-connected structure, and the epidermal and dermal layers were fully restored in the SOCS-com group ( Figure 5B). In addition, the overall number of inflammatory cells was dramatically reduced (Figure 5C,D). Taken together, the comprehensive histological results indicated that co-transfection with SOCS-com reduced the widespread inflammation response and accelerated the woundhealing process the most, demonstrating its superior therapeutic potential. ...
