Figure 1 - uploaded by Sushma Prabhath
Content may be subject to copyright.
H&E stained section (10x) of duodenum, jejunum and ileum during all three trimesters. (A. First trimester, B. 2 nd Trimester, C. 3 rd Trimester. 1-Mucosa, 2-Submucosa, 3 -Muscularis Externa).
Source publication
Background:
Intestine plays a major role for the normal growth of the fetus during the prenatal period. The process of the embryonic development is not quantified histologically. Therefore the main aim of the study was to measure the thickness of all part of the wall of the small intestine that are mucosa, submucosa and muscularis externa and to l...
Contexts in source publication
Context 1
... mucosal layer of the ileum increases in its thickness during the first and third trimester while its thickness decreases during the second trimester. The thickness increased here because of development of epithelium, villi (Fig. 1). The thickness of mucosal layer in the first trimester in in all three parts of the small intestines, duodenum, jejunum and ileum, seemed to be within the same range. In the second trimester, values of all the three are declined slightly. And in the third trimester, the value of the thickness of the jejunal mucosa is observed to be ...
Context 2
... the same thickness pattern as the duodenal mucosa during three trimester. The thickness pattern of submucosa in the jejunum shows the same results as the jejunal mucosa. But, the submucosal layer in the ileum shows no much difference during all three trimesters. The thickness of submucosal layer during all the trimester is moreover the same. (Fig. 1 There is significant difference in the thickness of the submucosa in the first trimester between duodenum and ileum. However, in the second trimester, there is no significant difference between all the three parts of small ...
Context 3
... relatively thicker in the first trimester than in the other two trimesters. The muscle layer in the jejunum is thinner than the muscle layer of the duodenum. And it shows constant thickness during all three trimesters. In the ileum, the thickness in the first trimester seemed to be increased than the thickness in the second and third trimester. (Fig. 1) There is no significant change in the thickness of muscularis externa in the first trimester as the standard error of mean (SEM) was high in duodenum. In the second trimester, thickness of jejunum is significantly higher than the ileum with p-value less than 0.05. In the third trimester, both duodenal and jejunal wall are ...
Context 4
... mucosal layer of the ileum increases in its thickness during the first and third trimester while its thickness decreases during the second trimester. The thickness increased here because of development of epithelium, villi (Fig. 1). The thickness of mucosal layer in the first trimester in in all three parts of the small intestines, duodenum, jejunum and ileum, seemed to be within the same range. In the second trimester, values of all the three are declined slightly. And in the third trimester, the value of the thickness of the jejunal mucosa is observed to be ...
Context 5
... the same thickness pattern as the duodenal mucosa during three trimester. The thickness pattern of submucosa in the jejunum shows the same results as the jejunal mucosa. But, the submucosal layer in the ileum shows no much difference during all three trimesters. The thickness of submucosal layer during all the trimester is moreover the same. (Fig. 1 There is significant difference in the thickness of the submucosa in the first trimester between duodenum and ileum. However, in the second trimester, there is no significant difference between all the three parts of small ...
Context 6
... relatively thicker in the first trimester than in the other two trimesters. The muscle layer in the jejunum is thinner than the muscle layer of the duodenum. And it shows constant thickness during all three trimesters. In the ileum, the thickness in the first trimester seemed to be increased than the thickness in the second and third trimester. (Fig. 1) There is no significant change in the thickness of muscularis externa in the first trimester as the standard error of mean (SEM) was high in duodenum. In the second trimester, thickness of jejunum is significantly higher than the ileum with p-value less than 0.05. In the third trimester, both duodenal and jejunal wall are ...
Similar publications
The present study was undertaken to explore the gross and histo-morphological details of the small intestine and was carried out on twelve
adult rabbits between body weights of 1.0 to 1.5 Kg. The tissue samples were processed, sectioned and subjected to specific stains to reveal
histological details. The general architecture was similar to other ma...
Citations
... The third trimester is a critical time in continuing intestinal growth and maturation. The small and large intestine are not only continuing to lengthen, but the villi are expanding in length and number, crypt fission is ongoing, and intestinal crypts are continuing to lengthen and mature in their composition (17)(18)(19). On a cellular level, not only are the Paneth cells continuing to functionally mature, but the intestinal stem cell niche is maturing and the numbers and types of epithelial secretory and absorptive cells is continuing to expand (20). ...
... On a cellular level, not only are the Paneth cells continuing to functionally mature, but the intestinal stem cell niche is maturing and the numbers and types of epithelial secretory and absorptive cells is continuing to expand (20). In the intestinal submucosa, important mesenchymal cell types and smooth muscle cells that are critical for supporting the ISC niche and protecting the submucosal space from the intestinal lumen are also growing and maturing (17), as is the mucosal immune system (21)(22)(23). There are likely to be important changes in microvasculature and the lymphatic lacteals in the villi that are still occurring as well, but this is not extensively studied. ...
Necrotizing enterocolitis (NEC) is a devastating disease of the neonatal intestine, causing widespread intestinal necrosis as well systemic illness that frequently results in death. Because the clinical onset of NEC is sudden and difficult to predict, NEC is considered an acute event. However, NEC does not occur in utero, meaning that postnatal exposures are required, and it does not typically occur right after birth, suggesting that longitudinal changes may be occurring before NEC can develop. In this perspective, the author considers whether NEC should be re-considered as a problem of disordered intestinal epithelial development, with required maladaptation over time prior to the onset of the necrotic event. This framework is similar to how bronchopulmonary dysplasia is currently conceptualized. They also advocate that NEC researchers incorporate this possibility into future studies on NEC susceptibility and pathogenesis.
... It is thought that Brunner's glands originate from the inward migration of stem cells through buds growing out of the duodenal crypt which subsequently acquire tubular or tubule-alveolar architecture in the submucosa same as neck cells migration and subsequent transformation into zymogenic cells in the gastric mucosa [16,17]. In particular, the role of trefoil peptides (proteins of the gastrointestinal tract regulating epithelial cell differentiation and mucus stabilization) in the development and function of the adult tubuloalveolar patter of Brunner's glands has been extensively investigated by Wright in a model mimicking their histogenesis: the ulcer-associated cell lineage [5]. ...
Adenocarcinoma of the small bowel is rather uncommon and several etio-pathogenic factors have been proposed. We report a case of multiple synchronous adenocarcinomas arising in the non-ampullary duodenum and first tract of the jejunum in a background of Brunner’s glands agenesia, chronic duodenitis, and extensive dysplasia in a 64 year-old woman. To the best of our knowledge such association has not been reported so far.
... This is particularly true with respect to the development and maturation of the GI system. The embryology of the GI system is considered in embryology textbooks and published scientific reviews (e.g., Carlson, 2014;Chin, Hill, Aurora, & Spence, 2017;Dauça et al., 1990;Drozdowski, Clandinin, & Thomson, 2010;Gilbert, 1989;Hamilton & Mossman, 1972;Kluth, Jaeschke-Melli, & Fiegel, 2003;Moore & Persaud, 2013;Noah, Donahue, & Shroyer, 2011;Sadler, 2012;Salva et al., 2019;Schoenwolf, Bleyl, Brauer, & Francis-West, 2015;Walthall, Cappon, Hurtt, & Zoetis, 2005). The following description is derived from those sources and applies to all the species considered herein. ...
The gastrointestinal (GI) system absorbs nutrients and xenobiotics, excretes waste, and performs immunologic and endocrine functions. The subdivisions of the mature gut and the complexity of their corrugated, absorptive luminal surfaces differ greatly among mammals. Regardless, the embryonic gut tube in all mammalian species arises when cephalocaudal folding incorporates the roof of the yolk sac into the embryo. The gut tube quickly lengthens and bulges into the umbilical cord. Upon reentry into the abdominal cavity, the gut tube begins to differentiate—a process that continues until well into the lactation period. Differentiation of the small intestine involves (1) increasing the absorptive surface area of the lumen; (2) establishing mechanisms to control the pH of luminal contents; (3) forming a hierarchical vascular system for distribution of absorbed nutrients; (4) developing a complex enteric nervous system to control motility; (5) providing a system for replenishment of cells; and (6) contributing to the immunity of the organism. Because the length of gestation varies among species typically used in safety tests and is much shorter than human gestation, the state of GI maturation at the time of parturition differs significantly. Differences in GI maturation can contribute to species differences in the rate and extent of absorption; these differences must be considered when designing and interpreting pharmacological/toxicological studies and extrapolating safety test results to humans.
