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... mean percentage of increment of healthy granulation tissue area was 51.73±31.87% in the experimental group and 14.57±47.57% in the control group (P=0.60, Table 4). Statistical significance was also not proven. Figure 3 shows the cumulative proportion of increased percentage of healthy granulation tissue area at each Ye-Na Lee, et al：Effect of Hyaluronic Acid Dressing on Diabetic Ulcer Healing -A Pilot Study - − 71 − ...
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The absence of interdental papillae leads to the appearance of black triangle. For most patients, the appearance of these triangles is an important reason for concern and affects their social relationships. Multiple reconstruction techniques have been developed with different degrees of success and predictability. The main aim of this study was to...
The absence of interdental papillae leads to the appearance of black triangles. For most patients, the appearance of these triangles is an important reason for concern and affects their social relationships. Multiple reconstruction techniques have been developed with different degrees of success and predictability. The main aim of this study was to...
A deep burn wound is a critical condition that generally necessitates vascularized tissue coverage. We performed the injection of platelet-derived factor concentrates combined with non–cross-linked hyaluronic acid scaffolds for 2 patients with critical burn wounds with bone and tendon exposure and achieved successful healing. Hyaluronic acid was co...
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... 3 Meanwhile, Lee Y et al., in 2014, with a smaller number of samples, found that in 3 weeks, there was a 51.6% reduction in wound area in diabetic foot ulcers given HA dressing compared to a 29.7% reduction in wound area in the group without HA dressing, but statistically, it was not significant (p=0.184). 18 Meanwhile, Hwang et al., 2016, in a prospective study, found that diabetic wounds treated with AH experienced a faster and more significant reduction in size (p = 0.012), namely, a 50% reduction in size could be achieved in 21 days compared to 39 days in diabetic wounds without AH. 19 The wound area in this study experienced a significant reduction in both the control and treatment groups. ...
... This study used an observation period of 2 weeks, while in previous studies, there were observations for more than 3 weeks. [17][18][19] In conclusion, topical hyaluronic acid and wound care using 0.9% NaCl reduced interleukin-6 levels, PUSH scores, and wound area in Wagner II-III diabetic foot ulcers. However, there was no significant difference in the decrease in interleukin-6 levels, PUSH Score and wound area in the administration of topical hyaluronic acid compared to wound care using 0.9% NaCl in the 2-week observation period. ...
Background: A diabetic foot ulcer is a complication that often occurs in patients with diabetes mellitus. The healing process of a chronic wound is more complicated and requires more complex treatment. There is an increase in IL-1, IL6, and TNF-α pro-inflammatory cytokines in a chronic wound. Hyaluronic acid (HA) is a component that has been used for a long time and is known to help the wound healing process. This study was at a time to determine the effectiveness of hyaluronic acid on the reduction of interleukin-6 in accelerating the healing of Wagner II-III diabetic foot ulcers. Methods: This study is an experimental, randomized study of pre and post-test design on diabetic foot ulcer patients with the Wagner II-III classification who were controlled at the thoracic, cardiac, and vascular surgery polyclinic at Dr. Soetomo Hospital Surabaya. Data were analyzed using SPSS version 20 for Windows. Result: About 39 samples are willing to participate in the study, divided into 20 samples in the treatment group and 19 in the control group. The mean concentrations of IL-6 in the treatment group before and after the intervention were 280.70±155.50 ng/ml and 126.60±145.60 ng/ml. There was a significant decrease in IL-6 levels (p<0.05) before and after the intervention. The mean concentrations of IL-6 in the control group pre and post were 315.20±127.40 ng/ml and 136.30±134.60 (p<0.05). The decrease in the control and treatment groups was no statistically significant difference (p>0.05). There was no significant difference in the PUSH Score (p>0.05) in the two groups before intervention/treatment. The decrease of wound area in the control and treatment groups were -4.80 ((-0.40)-(-24.50)) and -4.8 ((-0.70)-(-30.90)) (p>0.05). Conclusion: Topical hyaluronic acid and wound care using 0.9% NaCl reduced interleukin-6 levels, PUSH scores, and wound area in Wagner II-III diabetic foot ulcers.
... They noted similar results even in cases with exposed tendons and crush injuries in diabetic patients, and even in infections caused by antibiotic-resistant strains. Fejfarová et al [61]also reported favorable outcomes of reduced ulcer dimensions using 1% acetic acid in diabetic foot ulcers, but the difference was not statistically significant. ...
Management of diabetic foot ulcers is the biggest challenge to the clinician, as conventional antibiotic therapies and local wound care have their own limitations. They are not effective for control of infections and promotion of healing because of cytotoxic effects. In view of cytotoxicity of routinely used topical antiseptic agents, this article focuses on the search of an ideal topical antiseptic agent that is safe and effective in controlling infectious agents and also in promoting the healing process. This review focuses on the use of various acids such as citric, acetic, hyaluronic, and hypochlorous acids as topical agents in diabetic foot infections. This article also focuses on the different roles of acids in the treatment of diabetic foot infections.
Nagoba B, Gavkare A, Rayate A, Mumbre S, Rao A, Warad B, Nanaware N, Jamadar N. Role of an acidic environment in the treatment of diabetic foot infections: A review. World J Diabetes 2021; 12(9): 1539-1549 [DOI: 10.4239/wjd.v12.i9.1539]
... However, as South Korean society progressed as a whole and attained better awareness of safety and accident prevention, the number of burn patients has been decreasing. HIRA database numbers indicate that the number of burn patients has gone down from 87,899 in 2010 to 20,191 in 2015. Today, most major burn patients are managed at several hospitals specializing in burn care, with specialists and the requisite equipment and facilities at hand; these specialized hospitals can be found in each province. ...
... The authors' group has performed two clinical trials to confirm the efficacy of two biologic dressing products developed in South Korea that are composed of collagen and hyaluronic acid (Healoderm; Genewell and Colladerm; SK Bioland), and the results were promising. 19,20 In addition, a new artificial dermis (Insuregraft; SK Bioland) has recently been developed. ...
In spite of a period of intense economic, social, and political hardship following the Korean War, the Republic of Korea has made great strides in economic growth over the past half century, and also remarkable progress in the medical field. However, wound research has been slow to take off in South Korea. Meanwhile, as is the case in many countries in Western Europe and North America, South Korea is seeing a steady increase in its aged population. The growth in the geriatric population has in turn brought on more cases of chronic wounds. Though South Korea only began to recognize the importance of wound management in the early 2000s, it was fortunate enough to have sophisticated related industries, such as biotechnology and information technology, and brilliant, industrious, and eager wound researchers, contributing to rapid development of the field. The country has particular strengths in research for innovative cell-based treatments and products for managing wounds. Notwithstanding government policy ill-equipped to sufficiently support such advancement, better communication between experts and public officials will no doubt bring forth even more achievements in this very promising field. It is in this context that this article aims to summarize current wound management practices, research, training, product development, and government policies regarding wound management in South Korea as of the year 2017. This article is protected by copyright. All rights reserved.
