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Giant cells with osteoid -bone formation, hematoxylin -eosin ×10.

Giant cells with osteoid -bone formation, hematoxylin -eosin ×10.

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Figure 1. Giant cells with osteoid -bone formation, hematoxylin -eosin ×10.
Figure 2. Giant cells with bone formation, hematoxylin -eosin ×10.
Figure 3. Tumor giant cells, hematoxylin -eosin ×20.
Figure 4. Surgical margins, hematoxylin -eosin ×4.
+1 Figure 5. Immunohistochemistry, CKAE1/AE3 ×10.
Osteoclastic Giant Cell Tumor of the Pancreas with Osteoid and Bone Formation: A case report.
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  • Jan 2021
Background: Extraosseous giant cell tumors involving visceral organs (pancreas, kidneys, bladder, etc.) and soft tissues present similar histological features to those occurring in the bones. Rarely, they may affect pancreas and their origin remains still controversial, with some authors supporting the epithelial and some others the mesenchymal ori...
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... stroma between these cells was fibrotic, with prominent bone and osteoid formation, at the edge of which quite a lot of the multinucleated giant cells were attached. (Figures 1-4) Also, there were a lot of hemosiderin-laden histiocytic aggregations. The mitotic count was low (checked also with Phospho-Histone H3 antibody), ranging to 3-4 mitoses / 10 high resolution visual fields (×400). ...

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